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Replication Data for: Repressive gene regulation synchronizes development with cellular metabolism

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Metabolic conditions affect the developmental tempo of most animal species. Consequently, developmental gene regulatory networks (GRNs) must faithfully adjust their dynamics to a variable time scale. We find evidence that weak repressors of gene expression provide the necessary coupling between GRN output and cellular metabolism. Using a mathematical model that is able to capture this feature of GRNs, we show that developmental errors that occur when a repressor is lost are greatly diminished in frequency if cellular metabolism is slowed. This dataset includes all of the simulations described in our study.

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  • 02/14/2019
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