Bioresponsive imaging probes act as beacons to allow detection, tracking, and study of otherwise invisible actors in biological systems. Understanding how these underlying systems function in their native context is essential to identifying dysfunction and generating effective remedies. Magnetic Resonance techniques are particularly interesting for this application because of the diverse strategies that can be employed to study targets of interest. Herein, multiple approaches to studying biological systems using bioresponsive probes are presented. Targeted probes for receptor visualization by MR and nuclear imaging are described, as are multiple approaches to harness the unique magnetic properties of several lanthanides to sense local pH, oxygen levels, or enzyme activity.

Creator

• Caldwell, Michael Allen

DOI

• https://doi.org/10.21985/n2-tyvv-0p30

Subject

• Inorganic chemistry

Language

• en

Alternate Identifier

• http://dissertations.umi.com/northwestern:14712
• etdadmin_upload_668587

Keyword

• Imaging Probes
• Molecular Imaging
• Lanthanides
• Magnetic Resonance Spectroscopy
• Magnetic Resonance Imaging

Date created

• 2019-01-01

Resource type

• Dissertation

Rights statement

• In Copyright