Sequential change-point detection for time series enables us to sequentially check the hypothesisthat the model still holds as more and more data are observed. It’s widely used in data monitoring
in practice. In this work, we propose two models: Binomial AR(1) model and Generalized
Beta AR(p) model, for modeling binomial...
Dendritic microstructures form during the solidification of a variety of metal parts, from traditionally cast engine blocks to 3D-printed specialty tooling. These dendrites can evolve through growth, coarsening, fragmentation, and the formation of a Columnar-to-Equiaxed Transition (CET), which all can greatly affect material properties. However, the basic science behind these...
In this paper we begin the study of the (dual) Steenrod algebra of the motivic Witt cohomology spectrum H_Wℤ by determining the algebra structure of H_Wℤ∗∗H_Wℤ over fields k of characteristic not 2 which are extensions of fields F with K^M_2(F)/2=0. For example, this includes all fields of odd characteristic,...
Learning to read is a complex process that requires integration across sensory, cognitive, and linguistic processes. Accordingly, there are numerous process that may lead to early reading difficulties. The earlier these difficulties are found, the more effective interventions can be, and the deleterious effects of falling behind in reading cannot...
This dissertation contributes to the theory of segregation and methodologies to measure it. The first two chapters focus on the traditional problem of quantifying segregation in traditional survey data through segregation indices. Segregation indices describe the segregation of an environment with one number – usually from 0 to 1. The...
DNA double-strand breaks (DSBs) are caused by either endogenous agents or exogenous ionizing radiation and chemicals. Incorrect DSB repair can lead to undesired genome rearrangements. Homologous recombination (HR) and non-homologous end-joining (NHEJ) pathways are two major DNA repair pathways that repair DSBs and maintain genome integrity. When homologous DNA is...
Biological experiments involving the manipulation and analysis of cells have always strived towards greater precision and resolution. Recent advances in micro and nanotechnology have improved the precision of manipulation and the resolution of analysis down to a single cell, thus opening new avenues of investigation. These advances have added a...
This dissertation is the culmination of a four-year project on local governments and local economic activity during the Great Depression in the United States (1929 - 1937). Chapter 1 investigates how U.S. municipal governments coped during the Depression and studies whether debt-induced financial constraints affected local public good provision. Local...
Herpes simplex virus (HSV) encephalitis (HSE) is the most common cause of sporadic fatal encephalitis, and despite targeted antiviral therapy, outcomes remain poor. While rare in adults, neonates are significantly more susceptible to severe HSV disease. Understanding both the host and viral factors that contribute to pathogenesis is critical to...
The goal of this dissertation is to develop models, algorithms, and interaction protocols to improve the efficacy and quality of Human-Autonomy Interaction (HAI) in the domain of assistive robotics. In this domain, the most common control paradigm is that of manual teleoperation using control interfaces such as joysticks, switch-based head...