Actin polymerization is responsible for the protrusion of filopodia and lamellipodia in immune, cancer, and other motile cells, as well as for propulsion of some intra cellular pathogens. Protrusion of a lamellipodium by the very filaments supporting the membrane load operates by the Brownian ratchet mechanism, with overall organization governed...
A primary limitation of non-viral gene therapy is the low level of expression achieved. One of the reasons that higher expression is not achieved is that there are many physical obstacles that prevent the DNA from reaching the nucleus to be expressed. A plasmid must cross the cell membrane, traverse...
On average, homosexual people are more gender nonconforming than heterosexual people. They also show increased distress, possibly due to their stigmatized minority status. Not surprisingly, gender nonconformity and psychological distress may be related, particularly in homosexual men (e.g., Skidmore, Linsenmeier, & Bailey, 2006), although the mechanisms explaining this relationship have...
A study of the optical properties and superconductivity in semiconductors is presented using the highly precise all-electron full-potential linearized augmented plane wave (FLAPW) density functional calculations.
Optical properties [$\varepsilon(\omega)$,$n(\omega)$,$k(\omega)$,$R(\omega)$ and $\alpha(\omega)$] of some III-V semiconductors [InAs, InSb, GaSb, and AlSb] and their critical point (CP) energies, are calculated from the...
In the same way that a sculptor shapes a block of stone to reveal the ideal form within, one's relationship partner can help one to become more like one's ideal self (Drigotas, Rusbult, Wieselquist, & Whitton, 1999). This interpersonal process is called "the Michelangelo phenomenon." The current research examines whether...
The perinucleolar compartment is a nuclear substructure that is associated with, but structurally distinct from the nucleolus. Previous studies have shown that the PNC preferentially forms in cancer cells and PNC prevalence (% of non-mitotic and non-apoptotic cells in a population with one or more PNC) is a prognostic in...
We can represent many real-world data sets as data streams and/or high-dimensional data. Major stock market such as New York Stock Exchange (NYSE) trades more than 8000 financial products daily, which generates massive trading time series in the form of data streams. NetFlow and DNS querying data generated by real-time...
In three essays, this dissertation examined the associations between child characteristics, interparental discord and various aspects of child development and physiological functioning. In the first essay, using longitudinal, nationally representative data on infants and their families from the early childhood longitudinal study (ECLS-B), results revealed small, but significant associations between...
This dissertation aims at contributing to the literature of organizational learning and organizational change. More specifically, this dissertation focuses on three fundamental issues of exploitation and exploration: the relationship between exploitation and exploration, the balance of exploitation and exploration, and the performance implications of exploitation and exploration. This dissertation comprises...
Cellular interactions are important for the development and maintenance of tissue structural integrity. In the developing neuroepithelium, the adherens junction proteins, N-cadherin and β-catenin, are highly enriched at the apical surface of the proliferative ventricular zone and have been suggested to have critical functions in ensuring the proper development of...