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- Description:
- Autism spectrum disorder (ASD) and intellectual disability (ID) are two of the most highly prevalent neurodevelopmental disorders (NDDs), each affecting roughly 2% of the population. Despite the need for therapies, few exist due to a myriad of challenges, such as the complex underlying genetic etiology and historic inaccessibility of neural...
- Keyword:
- PACS1 syndrome, Induced pluripotent stem cells, Single-cell RNA sequencing, Intellectual disability, Cerebral organoids, and Autism spectrum disorder
- Subject:
- Molecular biology and Neurosciences
- Creator:
- Rylaarsdam, Lauren Elizabeth
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 05/31/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_984633 and http://dissertations.umi.com/northwestern:16538
-
- Description:
- The production and spread of digital news involves a wide range of actors: journalists and the organizations that employ them, social media platforms, audiences, and myriad commentators, citizen journalists, bloggers, and other actors who contribute to the news ecosystem without inhabiting an official role. These actors interact in flexible, often...
- Keyword:
- computational social science, algorithms, digital journalism, simulation, network analysis, and complexity
- Subject:
- Journalism, Computer science, and Communication
- Creator:
- Hagar, Nicholas
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 05/31/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_984386 and http://dissertations.umi.com/northwestern:16531
-
- Description:
- This dissertation presents an affect-centered approach to the analysis and interpretation of the experience of music and its attendant meaning in selected works of literature and cinema. Music’s interpretative mutability often charges it with meaning, though in infinite gradations of singularity rather than any universal sense. Rather than undertake a...
- Subject:
- French literature and Music
- Creator:
- Jackson, Colin
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 05/31/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16432 and etdadmin_upload_965301
-
- Description:
- Vertebrate brains evolved to facilitate a diverse array of behaviors and internal cognitive processes. Theories of neural function have proposed that neural computation is organized within populations or ensembles of neurons. Here, we identify ensembles of neurons in the striatum, the main input nucleus of the basal ganglia, in which...
- Keyword:
- Wireless Optogenetics, Basal Ganglia, Striatum, Dopamine, Neural Ensemble, and Population Activity
- Subject:
- Neurosciences
- Creator:
- Minkowicz, Samuel
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 05/31/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16515 and etdadmin_upload_983540
-
- Description:
- This dissertation studies three markets with regulated prices. I focus on how these regulations shape the behavior of firms along non-price dimensions. Chapter 1 studies the effects of community rating regulations in the US individual health insurance exchange market. In this market, the Affordable Care Act established community rating areas...
- Keyword:
- Industrial organization, Health economics, and Applied microeconomics
- Subject:
- Economics
- Creator:
- Geddes, Eilidh
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 05/31/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16454 and etdadmin_upload_971770
-
- Description:
- The dissertation project considers the generative possibilities to envision Black subjectivity that emerges from a sustained consideration of different forms of difficult racial and sexual intimacies. The artists whose work is engaged throughout the project, Leasho Johnson, Ajamu X, and NIC Kay recognize that to be Black is to always...
- Keyword:
- Black Visual Culture, Gender and Sexuality Studies, Black Studies, Intimacy, Queer Studies, and Performance Studies
- Subject:
- African American studies
- Creator:
- Marsh, Gervais
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 05/31/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_987546 and http://dissertations.umi.com/northwestern:16619
-
- Description:
- Chapter 1. Caste, Bureaucracy, and the Limits to Political Affirmative Action. The aim of political affirmative action policies is to ensure that disadvantaged groups are represented in their governments and, in turn, that laws preferred by this group are more likely to be instituted. Often, however, they have not been...
- Keyword:
- citizenship, affirmative action, contagion, caste, bureaucracy, and political economy
- Subject:
- Economics
- Creator:
- Campillo Betancourt, Eduardo
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 05/31/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_986068 and http://dissertations.umi.com/northwestern:16575
-
- Description:
- Human olfactory function is important for a myriad of behaviors, including food seeking, social cognition, memory, emotional regulation, and detecting environmental threats. In animal models, particularly dense olfactory inputs have been shown to target orbitofrontal cortex (OFC), a region involved in multimodal sensory integration, reward coding, and flexibly guiding our...
- Keyword:
- aging, tractography, olfaction, alzheimer's disease, orbitofrontal cortex, and diffusion magnetic resonance imaging
- Subject:
- Neurosciences
- Creator:
- Echevarria-Cooper, Shiloh Luela
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 05/31/2023
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16387 and etdadmin_upload_952134
-
- Description:
- In the first part of the thesis we,given a dg-Lie algebra $\g$, a commutative dg-algebra $A$ and a twisting cochain $\mu$ in $A \otimes \g$, we construct a map from the functor of curved deformations of $\g$ to the functor of curved deformations of the twisted tensor product $A \otimes_\mu...
- Keyword:
- L-infinity algebras, Lie coalgebra, A-infinity algebras, Period map, Quantization, and Deformation theory
- Subject:
- Mathematics
- Creator:
- Papayanov, Grigory
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 05/31/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_985714 and http://dissertations.umi.com/northwestern:16566
-
- Description:
- Neuroblastoma is one of the most common childhood cancers with one of the lowest survival rates, accounting for 15% of childhood cancer mortality. Approximately 15% of patients do not respond to initial treatment, and about half of children treated for high-risk neuroblastoma will relapse following remission. Ionizing radiation has long...
- Subject:
- Cellular biology
- Creator:
- Ritner, Carissa
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 05/31/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_977952 and http://dissertations.umi.com/northwestern:16470