MAPK-interacting kinase (MNK) signaling leads to activation of cap-dependent mRNA translation through phosphorylation of the eukaryotic translation initiation factor 4E (eIF4E). In cancer cells, MNK-eIF4E signaling promotes translation of oncogenic mRNAs. In glioblastoma (GBM), the deadliest malignant brain tumor, MNK-eIF4E signaling is aberrantly activated and represents a promising therapeutic target....
In this presented study, rolling in micro scale level, termed as microrolling, has been advanced and extended its application to surface texturing and roll bonding. Meanwhile, continuous direct current (DC) is introduced to the processes to establish two new microrolling processes: the Electrically-assisted Roll Bonding (EARB) and the Electrically-assisted Microrolling-based...
Efficient and accurate processing of internally- and externally-generated information is enhanced by the presence of multisensory signals that can provide redundant information about percepts or events. However, efficient usage of multisensory signals requires implicit perceptual knowledge of the potential or likely relationships between signals encoded within each sensory modality. If...
Space, time and energy are the three most fundamental elements in our intellectual understanding of the physical world. Here, I found how these same elements also contribute to a stable and coherent representation that the motor system forms by combining information from different sensory sources, such as vision, touch and...
Bulk heterojunction (BHJ) organic photovoltaic (OPV) devices have been extensively studied to achieve power conversion efficiencies well above 10%. New research into alternative materials that allow for cheaper and more industrially viable fabrication of flexible solar cells has been at the forefront of the energy field for the past few...
In this dissertation I pose a new puzzle about desire, one grounded in three plausible but jointly inconsistent propositions. According to the standard view in metaphysics, (1) all desires are dispositional states. Epistemologists, though, think that (2) we have privileged access to some of our desires. But (3) it is...
Moving away from fossil fuels requires environmentally friendly and economically viable alternative energy sources. A wide adoption of new technologies for energy production and storage depends on better performing materials. Computational methods, such as electronic structure calculations and machine learning, hold the promise to work in conjunction with traditional experimentation...
Services have been constantly evolving and operational efficiency has been a key initiative for progress. In this collection of academic papers, we investigate the efficiency of three different industry practices, to each of which we dedicate a chapter. Chapter 1 and Chapter 2 cover completed research, while the research covered...