This dissertation presents a program of research on cultural cognition of the natural world, involving long-term research with indigenous Ngöbe partner communities (Panama) and selected comparisons to Western samples (US). In two series of experiments focused on agency concepts, we show that cultural frameworks recruit distinct principles for inferring agency...
This dissertation studies the small dispersion asymptotics in highly stratified models. My goal is to show that accurate inferences are possible even if s, the number of strata, is large while m, the number of observations within each stratum, is small, provided that the model ”fit well” in the term...
In today's rapidly changing world, there is constant demand for the development of new, high performance materials. Fire resistant steels can provide greater safety in the event of a building fire, creep resistant stainless steels can allow for higher power plant efficiency, and cobalt based superalloys have potential for use...
Metabolite biosensors are powerful tools for basic biological research, medical diagnostics, and biotechnological applications. However, a generalizable strategy for developing new metabolite biosensors when an existing sensor cannot be found in nature, is a persistent challenge. Furthermore, while transcription factor biosensors have the broadest range of applications, the pool of...
The hormone prolactin (PRL) contributes to breast cancer pathogenesis through various signaling pathways, one of the most notable being the JAK2/signal transducer and activator of transcription 5 (STAT5) pathway. PRL-induced activation of the transcription factor STAT5 results in the upregulation of numerous genes implicated in breast cancer pathogenesis. However, the...
Ultrafast spectroscopy offers an unprecedented view on the dynamic nature of chemical reactions. From charge transfer in semiconductors to folding and isomerization of proteins, these all important processes can now be monitored and in some instances even controlled on real, physical timescales. One of the biggest challenges of ultrafast science...
While literature indicates that fewer than half of older adults aged 65 years or older receive high quality end-of-life care, less is known about the quality of end-of-life care experienced by the segment of that population with multiple chronic conditions (MCC). Drawing upon the Teno Model of high quality end-of-life...
Traditionally, research on perception and sensory systems has considered the senses as independent and modular functions that only converge after sufficient processing in unisensory areas. Recently, however, that view has been called into question with a number of demonstrations of multisensory interactions that may occur as early as primary cortex....
This dissertation investigates the evolution of national identification and assimilative trends among Germans who remained behind in the Czech lands from the end of the postwar expulsions in 1946 through the Czech Republic’s entry to the European Union in 2004. My primary lens of analysis is associational life, or formal...
The goal of this thesis is to design practical algorithms for nonlinear optimization in the case when the objective function is stochastic or nonsmooth. The thesis is divided into three chapters. Chapter 1 describes an active-set method for the minimization of an objective function that is structurally nonsmooth, viz., it...