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- Description:
- Genetic variation in genes regulating metabolism may be advantageous in some settings but not others. The non-failing adult heart relies heavily on fatty acids as a fuel substrate and source of ATP. In contrast, the failing heart favors glucose as a fuel source. A bootstrap analysis for genes with deviant...
- Keyword:
- Heart Failure, Glucose, Cardiomyopathy, Drosophila, Metabolism, and Mitochondria
- Subject:
- Molecular biology, Gender studies, and Cellular biology
- Creator:
- Fischer, Julie Anne
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/16/2023
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16326 and etdadmin_upload_941216
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- Description:
- Early life adversity predicts greater health risk in later life across multiple outcomes, including cardiovascular disease (CVD) and all-cause mortality. While biological pathways are incompletely understood, evidence is increasingly highlighting immune function, specifically chronic inflammation, which is implicated in cardiometabolic diseases, certain cancers, and all-cause mortality. Links between early adversity...
- Subject:
- Physical anthropology
- Creator:
- Aronoff, Jacob
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/16/2023
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_945998 and http://dissertations.umi.com/northwestern:16356
-
- Description:
- One of the fundamental questions in developmental biology is how a single cell gives rise to a complex organism. More specifically, how a totipotent egg divides into cells that become increasingly restricted in their potential. Development is a process of increasingly restricted cellular potential, and here I home in on...
- Keyword:
- Xenopus, Pluripotency, Neural Default Model, BMP, Smads, and Activin
- Subject:
- Biology and Developmental biology
- Creator:
- Johnson, Kristin Lorette
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/16/2023
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16347 and etdadmin_upload_945075
-
- Description:
- In this dissertation, I conducted 2 studies that resulted in 3 manuscripts. This dissertation consists of 6 chapters that include the 3 manuscripts. The overarching research question is How does context affect the work of quality improvement (QI) practitioners? To answer this larger research question, which is central to the...
- Keyword:
- Context, Quality Improvement, Scoping Review of Reviews, and Qualitative Research
- Subject:
- Health sciences
- Creator:
- Terwilliger, Iva Alyse
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/16/2023
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_945966 and http://dissertations.umi.com/northwestern:16355
-
- Description:
- Much prior research on memory systems has focused on establishing dissociations between different types of memory based on behavior, subjective experience, and the brain: explicit memory depends on the medial temporal lobe and is thought to operate consciously through a relatively slower processing bottleneck, while implicit memory is a term...
- Subject:
- Psychology
- Creator:
- Schmidt, Kevin
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/16/2023
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_890051 and http://dissertations.umi.com/northwestern:15980
-
- Description:
- This thesis presents results on photophysics and spin dynamics of photoactive organic molecules that possess one unpaired electron spin in the ground state and two or three unpaired spins upon photoexcitation. The excited state dynamics of the systems were studied using transient optical absorption spectroscopies and non-Boltzmann population on the...
- Subject:
- Physical chemistry and Chemistry
- Creator:
- Mao, Haochuan
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/16/2023
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_946833 and http://dissertations.umi.com/northwestern:16364
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- Description:
- Dopamine (DA) neurons are involved in many brain functions, and their dysfunction is associated with several neurodegenerative diseases. In recent years, our lab and others have found that DA neurons are molecularly diverse through single-cell gene expression profiling. An outstanding question in the field is whether this heterogeneity is encoded...
- Subject:
- Developmental biology
- Creator:
- Pereira Luppi, Maria Milagros
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/16/2023
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16348 and etdadmin_upload_945123
-
- Description:
- Selecting the best material to deliver optimum performance in real-world applications is one of the most significant challenges in engineering. Hundreds of thousands of computationally-predicted, but experimentally unexplored materials exist today in the public inorganic material databases as candidates for consideration. This thesis discusses three projects in the domain of...
- Keyword:
- statistical modeling, materials design, uncertainty quantification, materials selection, computational materials, and materials informatics
- Subject:
- Materials Science
- Creator:
- Gopakumar, Abhijith Mini
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/16/2023
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_947056 and http://dissertations.umi.com/northwestern:16368
-
- Description:
- This research questions how institutional logics shape and change through the event sequencing of institutional reforms. Literature reviewed on sequences of social events underspecifies the enchainment of events, i.e., the set of social processes that both links events and also renders the sequence meaningful beyond summing its individual events. My...
- Keyword:
- institutional logics, institutional reforms, organizational institutionalism, Latin America, event sequencing, and qualitative methods
- Subject:
- Management and Organization theory
- Creator:
- Milner, Daniel
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/16/2023
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_941589 and http://dissertations.umi.com/northwestern:16331
-
- Description:
- Superconducting-circuit based platforms are strong contenders in the race to build a quantum computer.While the transmon has had extraordinary success as the leading superconducting qubit modality, there are reasons to believe that other types of qubits could possess relative benefits in terms of noise immunity, anharmonicity, or extensibility. In this...
- Keyword:
- fluxonium, Superconducting circuits, Quantum computing, and current mirror
- Subject:
- Physics and Quantum physics
- Creator:
- Weiss, Daniel Kamrath
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/16/2023
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_933500 and http://dissertations.umi.com/northwestern:16292