This dissertation describes the development and use of novel chemical affinity templates to direct the assembly and preserve the activity of biological molecules in surface- and solution-based biomolecular assays. The majority of work described herein focuses on advancing biological nanoarray technology to enable the study of fundamentally important biological processes...
It has commonly been observed that a person's performance on a self-regulation activity is often impaired when he or she has already performed a prior task that requires substantial self-regulation, a phenomenon termed as the regulatory depletion effect. The prevailing explanation for this effect, as reported in the literature, is...
A spokesman for the American Revolution, John Adams, famously claimed that a third of colonists supported independence, a third supported Britain, and a third remained neutral. Since then historians have struggled to understand the mixed loyalties of the Revolutionary generation.
"The Popular Politics of Loyalism During the American Revolution, 1774-1790,"...
Assets are ubiquitous, required for consumer behaviors and meaningful in American society. Though assets have a central role in society, they have been considered primarily for what they can buy. This continual focus on assets as an instrument for exchange masks the fact that assets also may serve as a...
UV Raman spectroscopy is a powerful tool to investigate hydrocarbons-zeolite systems, including the coke formation mechanism during MTH reactions, the sorbet-framework interactions and the quantitative analysis of catalytic reactions.
First, methanol, dimethyl ether and ethylene reactions were carried out on H-MFI with different Si/Al atomic ratios to study the coke...
The work described here includes both fundamental and application based studies centered around the use of plasmonic sensors. Fundamental studies focus on probing the optical properties of nanosphere lithography (NSL) fabricated Ag nanoparticles, while surface-enhanced Raman spectroscopy (SERS) sensors are applied to identify and characterize artists' red dye and red...
The ubiquitin-proteasome system degrades regulatory proteins and thereby controls a broad range of cellular processes such as the cell cycle, DNA-repair, gene transcription and signal transduction. The proteasome typically degrades its substrates completely into small peptides. However, biological exceptions do occur. For example, the activity of a handful of transcriptional...
The [(salen)CrCl + LB] catalyst system was found to be a highly active catalyst system for the [aziridine + CO<sub>2</sub>] coupling reaction, and exhibited a marked preference for the formation of 5-substituted oxazolidinone product, especially in the absence of cocatalyst. The activity of this catalyst system is optimized by modifying...
This dissertation examines the impact of product returns on effective supply chain management. Within this area of research, known as Closed-Loop Supply Chain Management, we consider both strategic and tactical level reverse logistics and inventory management problems from the perspective of a firm which must efficiently process returned items. More...
The stratigraphic record of the Phanerozoic provides key evidence of temporal changes in the global carbon cycle over the past 560 myr of Earth history. Measurements of carbon concentrations in ancient marine sediment, in conjunction with a chronological framework, provide a means to reconstruct burial flux history and, thus, evaluate...