Molecular self-assembly is a process in which molecules spontaneously form ordered aggregates, the process of which is important in the natural world, considering those ordered systems and complex architectures contained in a living cell. The goal of chemists is to design simple molecules or chemical systems that can undergo molecular...
Biochips and high-throughput screening methods are powerful tools for studying biological processes. The combination of peptide arrays and SAMDI mass spectrometry incorporates these tools to study a broad range of biochemical transformations, including enzyme activities, to provide valuable information on substrate recognition and guide the development of diagnostic and therapeutic...
Plant life history traits influence the extent and degree of gene flow across a species range. The resulting genetic neighborhood size can influence population differentiation and the scale of local adaptation, with implications for species response to environmental change and sourcing of plant materials for ecological restoration. To assess the...
The Gramm-Rudman-Hollings Act (or “GRH”), which unprecedentedly provided for “sequestration”, a doomsday device to enforce fiscal discipline upon Congress and the President, was passed with bipartisan support on December 12, 1985. How did GRH take place, and why did it assume its final form? Casting GRH’s enactment in functionalist and...
The invention of GdIII-based magnetic resonance imaging (MRI) probes substantially expanded the capability of MRI in visualizing details in tissue. Building upon the achievement of GdIII-based complexes, more ideal probes should feature contrast that is responsive to biomarkers, such as redox status and ion concentrations. The abnormality of these biomarkers...
In response to exponentially increasing demand for digital media, today's Internet landscape has evolved into a multitude of diverse and interdependent distribution systems designed to move content as efficiently as possible. While many of these systems have \emph{individually} been explored in depth by both academic and industrial communities, a cross-sectional...
To relate the mechanical responses of hard-soft copolymer systems with their microstructures, a coarse-grained molecular dynamics (CGMD) approach is employed. With the generic bead-spring polymer model mapped from atomistic simulations, this dissertation first studies the morphology of structures with various hard-soft compositions and interactions between hard beads. Following that, this...
The start of the 21st century brought the sweeping proliferation of portable electronics such as laptops, tablets, and smartphones. These technologies were largely enabled by advances in energy storage methods – lithium ion batteries in particular. Society's push for more advanced energy storage applications, such as electric vehicles, stresses the...
This dissertation explores Holocene climate change along the west coast of Greenland and late Holocene climate variability in the subpolar North Atlantic region using paleolimnology. Lake sediment archives and the climate proxies contained within them provide a valuable window into past temperature change on Greenland, home to one of Earth’s...
Assistive robotics focuses on human-robot systems that provide physical support and assistance to the elderly and people with motor-impairments. While assistive machines, such as the powered wheelchair, can significantly enhance the functional independence of individuals, many users are challenged by their direct operation, the manner in which such systems are...