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Filtering by: Creator Mary P. Lambert Resource type Article

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Stabilizing Highly Pathogenic Nanoparticles Associated with Alzheimer’s Disease

Description:

When the Aß peptides aggregate into soluble oligomeric clusters, they form central nervous system neurotoxins known as amyloid-ß-derived diffusible ligands (ADDLs). The assembly of ADDLs is currently thought to be a pathogenic process in Alzheimer's disease (AD). Understanding the molecular structure and properties of ADDLs could prove useful in the...

Keyword:

Volume 5

Creator:

William L. Klein, Sarah Kate Rapoport, and Mary P. Lambert

Owner:

Scholarly Digital Publishing

Date Uploaded:

07/19/2018

Date Modified:

07/19/2018

Date Created:

2008

Resource Type:

Article
Solvent Effects on the Kinetics of Amyloid-b Oligomerization

Description:

Amyloid-β oligomers, also known as amyloid-β derived diffusible ligands (ADDLs), have been implicated in numerous studies as being a possible cause for Alzheimer’s disease (AD). The goal of this study was to investigate the kinetics of the oligomerization of the monomer amyloid-β (Aβ) into ADDLs in various ratios of dimethyl...

Keyword:

Volume 4

Creator:

Allison Meisner, William L. Klein, and Mary P. Lambert

Owner:

Scholarly Digital Publishing

Date Uploaded:

07/18/2018

Date Modified:

07/18/2018

Date Created:

2007

Resource Type:

Article