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Filtering by: Creator Tatyana A Klimova Subject Integrated Graduate Program in the Life Sciences

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Mechanisms of hyperoxia-induced senescence in primary human lung fibroblasts

Description:

Senescence, permanent, irreversible replication arrest that occurs in all primary cells studied to date, is considered a cellular model of aging. Recently, senescence has gained attention as a potential tumor-suppressing mechanism. However, despite the obvious importance of senescence, its exact mechanisms remain unclear. One current hypothesis to explain senescence postulates...

Keyword:

aging, p53, hyperoxia, senescence, and reactive oxygen species

Subject:

Integrated Graduate Program in the Life Sciences

Creator:

Tatyana A Klimova

Owner:

Scholarly Digital Publishing

Date Uploaded:

09/10/2018

Date Modified:

09/10/2018

Date Created:

2008-05-08

Resource Type:

Dissertation