Index Catalog // Arch : Northwestern University Institutional Repository

Start Over

Filtering by: Type Work Keyword Spherical nucleic acids

1 - 2 of 2

List Gallery Masonry Slideshow

Antiglioma Activity of Bimodal cGAS-Agonistic and STAT3-Inhibitiory Spherical Nucleic Acids

Description:

Stimulation of the cGAS-STING (cycle GMP-AMP synthase-Stimulator of Interferon Genes) pathway increases T cell activation and tracking into the tumor and reverses the immunosuppressive phenotype of myeloid cells. Direct targeting of the STING receptor using synthetic cyclic dinucleotide (CDN) ligands represents an attractive immunotherapeutic strategy for the treatment of lymphocyte-depleted...

Keyword:

GBM, Spherical nucleic acids, cGAS, Immunotherapy, and STING

Subject:

Biology, Biochemistry, and Immunology

Creator:

Mahajan, Akanksha Sanjay

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

05/31/2023

Date Created:

2023-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_983546 and http://dissertations.umi.com/northwestern:16516
Overcoming Temozolomide Resistance in Glioblastoma Multiforme with MGMT-Targeting Spherical Nucleic Acids

Description:

Glioblastoma multiforme (GBM) is the most prevalent primary central nervous system malignancy. Due to the aggressive nature of these tumors and our inability to adequately treat them, only 3-5% of patients survive longer than 3 years post-diagnosis. The standard of care for newly diagnosed GBM is surgical resection followed by...

Keyword:

siRNA, Ribozyme, Glioblastoma, Spherical nucleic acids, Gold nanoparticles, and MGMT

Subject:

Interdepartmental Biological Sciences (IBiS) Graduate Program

Creator:

Timothy L. Sita

Owner:

Scholarly Digital Publishing

Date Uploaded:

03/12/2018

Date Modified:

03/12/2018

Date Created:

2017-01-01

Resource Type:

Dissertation

LIBRARIES | ARCH

Limit your search

Type

Resource type

Creator

Keyword

Subject

Language

Antiglioma Activity of Bimodal cGAS-Agonistic and STAT3-Inhibitiory Spherical Nucleic Acids

Overcoming Temozolomide Resistance in Glioblastoma Multiforme with MGMT-Targeting Spherical Nucleic Acids

Limit your search

Search Constraints

Search Results