The growth cone is a highly specialized motile structure with a distinctive and dynamically variable morphology. Current understanding of actin-based protrusive motility has been formulated in terms of the dendritic nucleation/array treadmilling model for lamellipodial protrusion and the convergent-elongation model for filopodial protrusion, that were based upon results obtained primarily...
The neural crest is a population of multipotent precursors that are found only in vertebrate embryos. These cells migrate extensively throughout the body and give rise to diverse derivatives, including craniofacial bone and cartilage, melanocytes, and the enteric nervous system. There is a large network of factors involved in neural...
This dissertation articulates the practice of clown theater by a Chicago-based company called 500 Clown in order to provoke further investigation and definition of this hybrid theatrical form, which, though increasingly popular as a practice, has yet to be theorized or historicized. This study addresses clown theater's relationships with other...
Dimensionally constrained material systems are at the forefront of current materials research because of their novel and often enhanced physical, chemical and biological properties. The dimensionality effects are pervasive through different classes of materials including ceramics, metals and polymers. Often times dimensionality effects are manifested as internal structure variations in...
A need exists to increase the functionality of myoelectric prostheses without increasing the mental requirement of operation. Implantable myoelectric sensors have made it possible to record multiple muscle activities with high fidelity. Given this high dimensionality of inputs, what is the best way of implementing control? Muscle synergies have been...
In this thesis we discuss the issue of solving stochastic optimization problems using sampling methods. Numerical results have shown that using variance reduction techniques from statistics can result in significant improvements over Monte Carlo sampling in terms of the number of samples needed for convergence of the optimal objective value...
Various methods for solving the partial contact of surfaces with regularly periodic profiles-- which might arise in analyses of asperity level contact, serrated surfaces or even curved structures--have previously been employed for elastic materials. A new approach based upon the summation of evenly spaced Flamant's solution is presented here to...
This dissertation concerns the rhetorical discourses that define a wireless technology revolution in the United States. This inquiry engaged in rhetorical criticism of key documents, texts and exigencies embedded within successive stages of the wireless revolution spanning twenty years. Three sites of discourse were analyzed: the wireless industry's vision and...
Using a novel DNA-microarray hybridization protocol, the diffusion distance during static microarray hybridization was estimated for Cy3- and Cy5-labeled cDNA probes as 3.8 and 2.6 mm, respectively, despite having almost identical molecular masses. Continuous mixing during microarray hybridization resulted in a 15-20% increase in signal intensity over arrays hybridized statically....
Two new methods have been developed employing silicon-containing molecules in novel organic transformations. The first strategy utilizes Lewis base-activation of triethoxysilylalkynes to deliver mild acetylide nucleophile equivalents. The second approach involves the use of enolate additions to acylsilanes to generate β-silyloxy homoenolate intermediates.
Lewis base-catalyzed activation of triethoxysilylalkynes promotes the...