The progressive women’s movement in the United States during the mid-twentieth century enjoyed increased support and success until national politics were dominated by conservatives during the 1980s. This dissertation analyzes the discourse around women’s issues created by two of the largest conservative women’s organizations, Eagle Forum and Concerned Women for...
Fungi have an immense untapped store of natural products, small molecules that can often be repurposed as pharmaceuticals. The genes that encode secondary metabolic machinery are often genomically co-localized into biosynthetic gene clusters. Because of the immense energetic costs that goes into producing the biosynthetic pathway and its products, strict...
This dissertation draws on a field-level, qualitative study of business analytics to explore the legitimation and design of knowledge practices. In the last few decades, both the power and the acceptance of business analytics have advanced dramatically; nonetheless, end-users and clients can still be deeply sceptical of particular analytics practices...
The circadian clock is a biological oscillator present in all terrestrial life forms that aligns organismal functions with the daily rising and setting of the sun. In mammals clocks are expressed both in pacemaker cells in the brain that are directly entrained by light as well as in all peripheral...
The ability to track labeled cancer cells in vivo would allow researchers to study their distribution, growth and metastatic potential within the intact organism. Magnetic Resonance (MR) imaging is invaluable for tracking cancer cells in vivo as it benefits from high spatial resolution and absence of ionizing radiation. However, many...
Short-wave infrared (SWIR) photon detection has become an essential technology in the modern world. Sensitive SWIR detectors with low noise levels, and high signal-to-noise-ratios are highly desirable for a variety of applications including light detection and ranging, optical tomography, and astronomical imaging. As such many efforts in infrared detector research...
The airway epithelium forms an active barrier between the internal and external environments and has multiple roles critical to normal function of the lung. Its development and function are controlled by a network of transcription factors that regulate gene expression in response to varying stimuli. Dysfunction of this tissue plays...
While infrequent, clay slope failures caused by earthquakes result in loss of life and substantial property damage. In strong seismicity areas, it is sometimes assumed that the stability of clay deposits can be evaluated through the residual undrained strength that is applicable at large deformations. A crucial factor missing in...
A disconnect exists between the behavior of transcriptional and genetic regulation in bacterial systems when comparing phenotypic patterns and dynamics of a population to those observed at the single cell level. In this thesis, we developed a number of tools and assays to better understand, overcome, and predict the challenges...
CD1 molecules represent a class of antigen presenting molecules that present lipid antigens to cognate T cells. These molecules have been identified in all mammals examined so far. Unlike MHC molecules, which are highly polymorphic, CD1 molecules exhibit limited polymorphism and are divided in to two groups – 1 and...