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Modeling, Analysis, and Control of Heterogeneous Multicellular Oscillators

Description:

No two cells in a population are identical to each other. Cell populations are almost universally heterogeneous, with their heterogeneity or variability often underlying complex emergent behavior and phenotypes. Heterogeneity presents a challenge to the discovery, characterization, and control of multicellular systems. Heterogeneity exists across multiple scales, ranging from the...

Keyword:

Circadian Rhythms, Systems Biology, Control Theory, Dynamical Systems, and Mathematical Modeling

Subject:

Bioengineering and Chemical engineering

Creator:

Balakrishnan, Narasimhan

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

06/22/2022

Date Created:

2022-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_879749 and http://dissertations.umi.com/northwestern:15942
Topology Inspired Methods for the Design and Analysis of Transcriptomic Time-Series Data in Circadian Biology Research

Description:

Circadian rhythms — physiological, behavioral, and metabolic oscillations with an approximate 24-h period — are controlled by an evolutionarily conserved set of core clock genes operating at the transcriptional and protein level. Entrainable by Zeitgebers (external environmental stimuli such as light, temperature, and food) that modulate time-of-day specific functions, the...

Keyword:

Differential Dynamics Detection, Time-Series Analysis, Dynamical Systems Theory, Circadian Rhythms, Topological Analysis, and Cycle Detection

Subject:

Biostatistics, Applied mathematics, and Bioinformatics

Creator:

Ness-Cohn, Elan Meir

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

06/22/2022

Date Created:

2022-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_875611 and http://dissertations.umi.com/northwestern:15905

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Modeling, Analysis, and Control of Heterogeneous Multicellular Oscillators

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