Protein-protein interactions are ubiquitous in living systems, and mediate important cellular processes from decision making to immunity against pathogens. Furthermore, protein-protein interactions are key to many protein therapeutics, pathogen diagnostics, and numerous synthetic biology applications. As a result, there has been significant effort to develop methods to express potential protein...
Throughout a synthetic organic chemist’s career, reaction planning, execution, and analysis will be repeated countless times. The objective of my thesis research was to expedite this workflow to more efficiently access to novel, complex, and biologically useful molecules and synthetic methods. Since the mid 20th century there have been several...
The diverse reactivity patterns, unique structural features imparted by the cumulated double bonds, and possibility of axial chirality have garnered allenes considerable attention in organic synthesis. Numerous methods have been described in the literature to afford optically active allenes starting from chiral starting materials, yet catalytic and asymmetric methods to...