Desmosomal cadherins are a recent evolutionary innovation that make up the adhesive core of highly specialized intercellular junctions called desmosomes. Desmosomal cadherins, desmogleins and desmocollins, are related to the classical cadherins but their cytoplasmic domains are tailored for anchoring intermediate filaments instead of actin to sites of cell-cell adhesion. The...
Erythropoietin-producing human hepatocellular (Eph) receptors and their corresponding ephrin ligands are asymmetrically expressed at cell-cell contacts allowing for bidirectional signaling with forward signaling through the receptor expressing cell and reverse signaling through the ligand expressing cell. Eph receptors are the largest family of receptor tyrosine kinases (RTKs) in mammals, which...