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The mitochondrial electron transport chain is necessary for NLRP3 inflammasome activation

Description:

The NLRP3 inflammasome is a multi-protein complex that drives sterile and pathogen-dependent inflammation. Activation of the NLRP3 inflammasome occurs in two steps: priming and activation. Priming occurs in response to an inflammatory stimulus, such as LPS. LPS-primed macrophages are subsequently activated by a second stimuli, most of which require K+...

Keyword:

macrophage, mitochondria, immunometabolism, inflammasome, and metabolism

Subject:

Biology

Creator:

Billingham, Leah Katherine

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

06/22/2022

Date Created:

2022-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:15953 and etdadmin_upload_882213
Factors contributing to Pseudomonas aeruginosa pathogenesis

Description:

Pseudomonas aeruginosa is a Gram-negative pathogen that frequently causes severe nosocomial infections through expression of virulence factors, evasion of immune clearance and resistance to therapeutic antimicrobial agents. These factors have led the US Centers for Disease Control and Prevention (CDC) and Infectious Disease Society of America (IDSA) to identify P....

Keyword:

Pseudomonas aeruginosa, antibiotic resistance, T3SS, and inflammasome

Subject:

Driskill Graduate Training Program in Life Sciences

Creator:

Ami Joy Hughes

Owner:

Scholarly Digital Publishing

Date Uploaded:

03/07/2019

Date Modified:

03/07/2019

Date Created:

2018-01-01

Resource Type:

Dissertation

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The mitochondrial electron transport chain is necessary for NLRP3 inflammasome activation

Factors contributing to Pseudomonas aeruginosa pathogenesis

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