The Escherichia coli ribosome is a molecular machine capable of sequence-defined polymerization of -amino acids into proteins, a feat unmatched by any other current synthetic catalyst. It is complex in its structure, comprised of 3 RNA parts (the 5S, 16S, and 23S ribosomal RNAs) and 54 ribosomal proteins (r-proteins). Efforts...
Regulatory RNAs are found throughout nature controlling critical cellular processes and enabling cells to sense and respond to their environment. In order to provide genetic regulation, these RNAs can selectively bind to target molecules, proteins, and invading pathogens, all while modulating gene expression on both the transcriptional and translational level....
The idea that structure determines the properties of a material is a powerful concept in chemistry and in all fields in which chemistry is important, including engineering, medicine, and materials science. My research aims to better understand the structure-property relationships of a class of materials known as metal–organic frameworks (MOFs)....
Economic growth in contexts of state weakness presents a puzzle. If the state’s provision of property rights is necessary for financial investment and related pro-growth behaviors, then why do we observe private investment and commercial transactions in settings where state institutions are far from reliable property guarantors? This study addresses...
Background. Rates of common bacterial sexually transmitted infections (STIs) are at an all-timereported high in the United States, while rates of new human immunodeficiency virus (HIV)
infections are declining. Among HIV-negative men and transgender women who have sex with
men, whom are theoretically at risk for both HIV and bacterial...
There is no group of materials as diverse, complex, and ubiquitous as polymers. From plastic bags, to rubber tires, electronics, food packaging, water filtration and even aerospace applications, the penetration of polymer materials into all aspects of life make them very important materials throughout all engineering fields. However, this breadth...
The advancement of nanotechnology is at least partially dependent on the ability to synthesize and arrange complex nanostructures on a substrate. Nanolithography, or the patterning of materials at the sub-micrometer length-scale, has been traditionally performed using a number of methods such as conventional photolithography, ion-beam etching, and electron-beam lithography. While...
Radiofrequency ablation is a minimally-invasive treatment method that aims to destroy undesired tissue by exposing it to alternating current in the 100 kHz to 800 kHz frequency range and heating it until it is destroyed via coagulative necrosis. Ablation treatment is gaining momentum especially in cancer research, where the undesired...
The dynamics of human joints are fundamental characteristic of the human motor system, and altered joint impedance can hinder mobility. Individuals with transtibial amputation typically experience slower and energetically costly gait, while individuals with chronic stroke experience persisting gait deficits arising from spasticity, hypertonia and paresis. Investigating joint impedance of...
Despite prevention and treatment, substantial risk for cardiovascular disease(CVD) remains in the population and CVD has been the leading global cause-of-death in past years.While high-density lipoprotein (HDL) markers such as HDL cholesterol (HDL-C) and HDL efflux (a cholesterol-transport-function assay) are associated with decreased risk of CVD, the mechanism of this...