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Tradeoffs Between Reproduction and Aging in the Human Epigenome

Description:

Evolutionary theory predicts that reproduction entails energetic costs that detract from somatic maintenance, accelerating biological aging. In women, such ‘costs of reproduction’ (CoR) are thought to arise predominantly during pregnancy and lactation, while in men the physiological effects of the steroid hormone testosterone (T) are believed to be a major...

Keyword:

Epigenetic clocks, Tradeoffs, Disposable soma theory, Costs of reproduction, Aging, and DNA methylation

Subject:

Genetics, Evolution & development, and Biology

Creator:

Ryan, Calen Patrick

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/01/2021

Date Created:

2020-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_780539 and http://dissertations.umi.com/northwestern:15395
Interaction between DNA methylation and progesterone action during uterine leiomyoma stem cell development

Description:

Uterine leiomyoma (LM), the most common tumor of women, causes severe morbidity. LM cells can be separated into three molecularly and functionally distinct cell populations based on the expression pattern of CD34 and CD49b: stem (LSC, CD34+/CD49b+), intermediate (LIC, CD34+/CD49b-), and differentiated cells (LDC, CD34-/CD49b-). Progesterone via progesterone receptor (PR/PGR)...

Keyword:

RANK/RANKL pathway, Progesterone signaling, Tumor stem cell, DNA methylation, and Uterine leiomyoma

Subject:

Biology

Creator:

Liu, Shimeng

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

01/21/2021

Date Created:

2020-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:15024 and etdadmin_upload_722143

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Tradeoffs Between Reproduction and Aging in the Human Epigenome

Interaction between DNA methylation and progesterone action during uterine leiomyoma stem cell development

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