Cellular translation is responsible for the synthesis of proteins, a highly diverse class of macromolecules that form the basis of biological function. In Escherichia coli, harnessing and engineering of the biomolecular components of translation, such as ribosomes, transfer RNAs (tRNAs) and aminoacyl-tRNA synthetases, has led to both biotechnology products (i.e.,...
Synthesis and characterization of mixed valent molecules which contain two or more metals in different oxidation states is a rich field of chemistry informing fundamental electronic structure and electron transfer theories. Traditionally these studies are concerned with the direct electronic interaction between metals, but recent work on redox non-innocent ligands...
Visual understanding is an important area in artificial intelligence. Many researchers have proposed novel deep learning models for this, which have achieved impressive results. However, deep learning models of visual understanding do not model human-like cognition and are still far from human-level ability. Standard deep learning models do not model...
In this dissertation, I summarize my findings of the dynamics of colloidal suspensions over a large range of volume fractions in two systems: drop impact and film rupture. The existence of a deformable surface in both these systems allows me to capture the consequences of non-Newtonian flow using high-speed imaging....
Understanding the mechanisms associated with chemical catalysis is vital for not only the rational improvement of their capabilities, but also for the advancement of the fundamental knowledge affiliated with the systems in question. These new insights can help predict new reactivities towards more challenging substrates which will allow for easier...
Dynamical modeling aims to capture the essential mechanics at work in real-world systems while remaining tractable enough to yield mathematical insights for predictions and interventions. The work presented here first takes this approach to the system of political ideology and influence, establishing a model for the continuous-time evolution of individual...
Chapter 1: If patients can be persuaded to switch between licensed providers on the basis of authoritative opinions, policy-makers can harness such reporting as a tool to implement incentives for high-quality care. I employ the landmark Flexner Report (1910) medical school evaluations to show that existing consumer beliefs and market-specific...
Elemental powder blends are an emerging alternative to prealloyed powders for high-throughput alloy design via additive manufacturing techniques due to their flexibility, low cost, and ease of customization. This dissertation investigates elemental alloying elements (Sc and Zr) which are high-melting and highly reactive, unlike previous work which focused on more...
This dissertation argues that writers and artists in Britain and its Empire in the first half of the twentieth century turned time and again to games and sports to find images and forms for their literary and artistic interventions. Furthermore, it shows how, in these works, play served as a...
Dark matter (DM) is one of the most outstanding problems in physics and is a promising hint for physics beyond the Standard Model. Many dark matter detection experiments have been built, with weakly-interacting massive particles (WIMP) as a popular DM candidate. There are also growing interest in light (keV-GeV)...