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-
- Description:
- The formation of neuronal inclusions is one of the hallmarks of neurodegenerative diseases. These structures are composed of aggregated proteins, molecular chaperones, and components of the ubiquitin-proteasome system (UPS). Co-localization of aggregated proteins with cell-homeostasis maintaining machinery indicates that the cell may be failing in an attempt to clear these...
- Keyword:
- Biology
- Subject:
- Biology
- Creator:
- Kwame Nyanten Mensah
- Owner:
- Scholarly Digital Publishing
- Date Uploaded:
- 05/07/2018
- Date Modified:
- 05/07/2018
- Date Created:
- 2006-11-30
- Resource Type:
- Dissertation
-
- Description:
- Physiological linkage (i.e., the covariation of moment-to-moment physiology between individuals) is thought to play an important role in relationship functioning. The present study examined physiological linkage across interbeat interval (IBI) and skin conductance levels (SCL) in a sample of married spouses (N=106) during both a pleasant and a conflict conversation...
- Keyword:
- marriage, physiological linkage, and emotional experience
- Subject:
- Psychology and Biology
- Creator:
- In Jung Jang, Claudia M. Haase, Ryan C. Svoboda, and Kuan-Hua Chen
- Contributor:
- Claudia Haase (advisor)
- Owner:
- Scholarly Digital Publishing
- Date Uploaded:
- 06/13/2018
- Date Modified:
- 06/13/2018
- Date Created:
- 2018-05-31
- Resource Type:
- Poster and Research Paper
-
- Description:
- Prostate cancer (PCa) is the most common non-cutaneous cancer among U.S. men. Lack of effective treatments for advanced disease make it a significant public health concern. However, PCa’s long natural history makes it an excellent target for prevention approaches that reduce overtreatment of indolent disease, treatment related morbidity, and mortality....
- Keyword:
- SELECT, Extracellular matrix, Prostate cancer, Reactive Oxygen Species, Organoids, and Fatty Acid Oxidation
- Subject:
- Molecular biology, Biology, and Cellular biology
- Creator:
- Njoroge, Rose Nyawira
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14428 and etdadmin_upload_623433
-
- Description:
- Some of the oldest drugs targeting metabolism are the antifolates such as aminopterin and methotrexate (MTX). MTX started being used in the 1950s to treat rheumatoid arthritis. Aminopterin and MTX both target one carbon metabolism and inhibit proliferation of cells. MTX was a potent inhibitor of inflammation, because it prevented...
- Keyword:
- macrophage, LPS, glutathione, metabolism, inflammation, and serine
- Subject:
- Biology
- Creator:
- Rodriguez, Arianne
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_638528 and http://dissertations.umi.com/northwestern:14513
-
- Description:
- Proteins represent a critical class of biomolecules, universally employed by all living organisms to fulfill essential structural, functional, and enzymatic roles necessary to support life. In nature, these polymers are composed generally of twenty natural amino acid (AA) building blocks, which can be modified with covalent adducts known as post-translational...
- Keyword:
- post-translational modification, genome engineering, cell-free protein synthesis, synthetic biology, orthogonal translation system, and non-canonical amino acid
- Subject:
- Bioengineering, Biology, and Biochemistry
- Creator:
- Des Soye, Benjamin James
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14473 and etdadmin_upload_627384
-
- Description:
- Phenotypic variation is the functional unit that evolution acts upon and is the main contributor to the diversity of species. The phenotype of an individual is shaped by genetic and environmental factors. These genetic and environmental factors contribute to biomedically relevant traits such as an individual’s susceptibility to disease and...
- Keyword:
- genetic diversity, arsenic, QTL, albendazole, etoposide, and C. elegans
- Subject:
- Biology and Genetics
- Creator:
- Zdraljevic, Stefan
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_683728 and http://dissertations.umi.com/northwestern:14790
-
- Description:
- Store-operated Ca2+ entry (SOCE) is a principal mechanism for generating cellular Ca2+ signals. Store-operated Ca2+ release-activated Ca2+ (CRAC) channels serve an essential role in generating Ca2+ elevations needed for transcriptional, enzymatic, and secretory effector cascades in many cell types. CRAC channels, comprised of the ER Ca2+ sensor STIM and the...
- Subject:
- Biology and Neurosciences
- Creator:
- Toth, Anna
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14766 and etdadmin_upload_679006
-
- Description:
- Platelets are circulating anucleate discs derived from megakaryocytes, and play major roles in hemostasis, inflammation, thrombosis, and vascular biology. Multi-phase culture systems for inducing in vitro platelet production from mature megakaryocytes have been explored to allow progenitor expansion, megakaryocyte maturation, and promotion of platelet formation and shedding. In this thesis,...
- Keyword:
- gaussian mixture models, stem cell differentiation, machine learning, and megakaryocyte
- Subject:
- Bioengineering, Bioinformatics, and Biology
- Creator:
- WU, JIA JIE
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_640286 and http://dissertations.umi.com/northwestern:14541
-
- Description:
- Transcription is tightly regulated to ensure genes are appropriately expressed both temporally and spatially. This tight regulation governs various processes within the cell, such as differentiation and cell identity, cellular maintenance, and dynamic responses to external signals. Transcription factors (TFs) coordinate these various gene programs and in particular, are key...
- Keyword:
- Repressor, NAFLD, PPAR alpha, BCL6, Transcription, and Metabolism
- Subject:
- Molecular biology and Biology
- Creator:
- Sommars, Meredith Anne
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_663025 and http://dissertations.umi.com/northwestern:14672
-
- Description:
- Microfluidic technologies enable multi-tissue culture and precise control of media exchange and therefore have significant potential to create more complex in vitro models of reproductive systems, including endocrine cycles. However, microfluidic technologies have largely been applied to gamete-level culture in reproductive biology, with very little progress in organ-level culture. Herein...
- Keyword:
- Toxicity, Oocyte, 3D Printing, Ovary, Microfluidics, and Islet
- Subject:
- Obstetrics, Biology, and Biomedical engineering
- Creator:
- Rogers, Hunter Bradley
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_661219 and http://dissertations.umi.com/northwestern:14603
-
- Description:
- Pathogenic bacteria scavenge essential nutrients including metals, amino acids and peptides to survive within the hostile host environment. Bacteria utilize ATP-binding cassette (ABC) transporters, powered by the energy of ATP hydrolysis, to move substrates across cellular membranes. The substrate-binding protein (SBP) shuttles substrate in the periplasm and directs the substrate...
- Keyword:
- ABC transporters, substrates, peptides, binding proteins, and heme
- Subject:
- Biology and Biophysics
- Creator:
- Tanaka, Kari J
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14534 and etdadmin_upload_640137
-
- Description:
- Store-operated Ca2+ entry through Orai1 channels mediate transcriptional, proliferative, and effector cell programs in many cells and are activated through a unique inside-out mechanism involving binding of the endoplasmic reticulum Ca2+ sensor, STIM1, to cytoplasmic sites on Orai1. Mutations in Orai1 that block channel activation or evoke constitutive channel activity...
- Keyword:
- Orai1, Gating, STIM1, Channel, CRAC, and Calcium
- Subject:
- Pharmacology, Biology, and Biophysics
- Creator:
- Yeung, Priscilla See-Wai
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_622219 and http://dissertations.umi.com/northwestern:14422
-
- Description:
- The critical importance of alternative mRNA splicing and the RNA binding proteins that orchestrate this essential layer of post-transcriptional gene regulation is increasingly recognized in gene regulatory programs. We and others have shown that alternative splicing plays a causal role during the Epithelial-Mesenchymal transition, a cell-developmental program that is hijacked...
- Keyword:
- splicing factor, RNA, EMT, alternative splicing, RNA binding protein, and metastasis
- Subject:
- Bioinformatics and Biology
- Creator:
- Harvey, Samuel
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14663 and etdadmin_upload_662828
-
- Description:
- Nanocarriers are nanometer-sized (1-1000 nm) structures capable of encapsulating cargo. This encapsulation can drastically alter the pharmacokinetic properties of the cargo, while also allowing for the rational design and engineering of the nanocarrier itself. Poly(ethylene glycol)-block-poly(propylene sulfide) is an amphiphilic diblock copolymer capable of self-assembling into diverse nanocarriers. The purpose...
- Keyword:
- flash nanoprecipitation, nanoparticle, copolymer, anti-inflammatory, and PEG-b-PPS
- Subject:
- Biomedical engineering and Biology
- Creator:
- Allen, Sean David
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14509 and etdadmin_upload_638353
-
- Description:
- Proper size control of organs and tissues is critical to their function, and it is necessary for the millions of precisely sized tubes that make up those organs— for example, excessive cell growth can lead to devastating diseases such as Polycystic Kidney Disease. The regulation of tube growth is therefore...
- Keyword:
- Trafficking, Non-apoptotic, Trachea, Caspase, and Apoptosis
- Subject:
- Molecular biology, Biology, and Cellular biology
- Creator:
- McSharry, Saoirse Susan
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_661142 and http://dissertations.umi.com/northwestern:14599
-
- Description:
- Individuals within a species vary in complex phenotypes, such as responses to toxins. This drug-response variation causes patients who are treated with the same medicine to experience a range of side effects, ultimately decreasing the efficacy of some drugs. Particular genetic variants among individuals might contribute to differential drug responses,...
- Keyword:
- genetics, bleomycin, linkage mapping, natural variation, drug response, and C. elegans
- Subject:
- Biology
- Creator:
- Brady, Shannon Colleen
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14708 and etdadmin_upload_667842
-
- Description:
- The epidemic of obesity and associated metabolic diseases have led to increased scrutiny of adipose tissue and its primary cell type, the adipocyte. However, studies show that regional adipose tissue distribution rather than obesity per se is a major determinant of metabolic disease risk. Despite having an obese body mass...
- Keyword:
- Lipogenesis, Insulin Sensitivity, Hypertrophy, Obesity, BCL6, and Adipocyte
- Subject:
- Biology, Endocrinology, and Genetics
- Creator:
- Senagolage, Madhavi Dushyanthi
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14575 and etdadmin_upload_658480
-
- Description:
- Inter-organelle contacts facilitate communication between organelles and impact fundamental cellular functions. Investigations into the molecular mechanisms of inter-organelle tethering are still in the early stages, and we are just beginning to appreciate the number and variety of inter-organelle tethers that exist. We have used budding yeast as a model polarized...
- Keyword:
- mitochondria and membrane contact sites
- Subject:
- Biology and Cellular biology
- Creator:
- Kraft, Lauren Michele
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_626904 and http://dissertations.umi.com/northwestern:14460
-
- Description:
- When a cell divides, it must assemble a microtubule-based structure called a spindle, which provides the forces that physically segregate the chromosomes. In most cell types the microtubules that comprise the spindle are nucleated and organized by centriole-containing centrosomes. In many species, however, oocyte meiosis is carried out in the...
- Keyword:
- Kinesin, Cell Division, Spindle, Meiosis, and Microtubule
- Subject:
- Biology
- Creator:
- Mullen, Timothy James
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_640242 and http://dissertations.umi.com/northwestern:14538
-
- Description:
- The literature has established glucokinase (GCK) to be the principal hexokinase (HK) in the liver, operating as a glucose sensor to regulate glucose metabolism and lipid homeostasis. We have recently proposed Hexokinase Domain Containing-1 (HKDC1) to be a novel 5th HK with expression in the liver. Here, we reveal HKDC1...
- Keyword:
- Hexokinase, NAFLD, Liver Metabolism, and HKDC1
- Subject:
- Molecular biology, Biology, and Biochemistry
- Creator:
- Pusec, Carolina
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14450 and etdadmin_upload_626205