Recovering three-dimensional (3D) structural information of a specimen from a single two-dimensional (2D) measurement remains an important but challenging task in microscopic imaging. A conventional 2D microscopic image has a shallow depth-of-focus (DoF). Thus, recovering 3D information usually requires sequentially z-scanning the focal planes. This process is time consuming and...
Nucleic acids not only are the building blocks of life but also a class of attractive macromolecular therapeutics. However, the delivery of therapeutic oligonucleotides into cells has been a major challenge due to their large size and highly negatively charged backbone. Spherical nucleic acids (SNAs) are a class of emerging...
When a cell divides, it must assemble a microtubule-based structure called a spindle, which provides the forces that physically segregate the chromosomes. In most cell types the microtubules that comprise the spindle are nucleated and organized by centriole-containing centrosomes. In many species, however, oocyte meiosis is carried out in the...
Automated sketch collaborators might help us create more dynamic intelligent tutoring systems, work out designs, reduce bias in solving spatial social problems, and organize our ideas. Here, we examine some properties of sketch recognition methods designed to help serve that goal. Structure Mapping techniques are applied to symbolic structural descriptions...
We use Goerss-Hopkins theory to show that if E is a p-local Landweber exact homology theory of height n and p > n^2 + n + 1, then there exists an equivalence hSpE ≃ hD(E∗E) between homotopy categories of E-local spectra and differential E∗E-comodules, generalizing Bousfield’s and Franke’s results to...
Unlike other products or services, electricity cannot be easily stored, and its delivery cannot be delayed by keeping customers in queues. The electricity supply has to be instantly available to serve a continuously varying demand. Traditionally, electric utilities would match their supply to the demand by adjusting the production output...
In the Nicomachean Ethics and Politics, I find that Aristotle endorses two distinct forms of political activity. The first form, which I term statesman activity, is intrinsically valuable. Aristotle thinks that we should value this kind of political activity because it is constitutive of human well-being. The second form, which...
The apolipoprotein E (APOE) E4 isoform is the strongest genetic risk factor for sporadic Alzheimer’s disease (AD). While APOE is predominantly expressed by astrocytes in the central nervous system, neuronal expression of APOE is of increasing interest in age-related cognitive impairment, neurological injury, and neurodegeneration. Here we show that endogenous...
Natural Language Processing methods have become increasingly important for a variety of high- and low-level tasks including speech recognition, question answering, and automatic language translation. The state of the art performance of these methods is continuously advancing, but reliance on labeled training data sets often creates an artificial upper bound...
Optical coherence tomography (OCT) is a high-resolution, non-contact, three-dimensional imaging technique, which has revolutionized the diagnosis and treatment of retinal diseases. Visible-light OCT (vis-OCT) extends OCT by enabling retinal oximetry – the measurement of oxygen saturation of hemoglobin from within individual retinal blood vessels. Three advances in the vis-OCT technique...