Image creation is an attempt to record a scene for presentation to a viewer. However, there is a precarious mapping between how a scene would be perceived and how an image is perceived. For example, although the human visual system does not have a strong absolute sense of color or...
Research shows that the most effective way to teach learners targeted skills is to put them in the kinds of situations in which they need to use them and to provide experts who are able to advise learners when necessary (Schank & Cleary, 1995). Through this process, learners come to...
In the process of development of a multicellular organism, cells must make stable, binary fate decisions in response to intercellular signaling. A critical question is how weak or transient activation of signaling pathways achieves a robust and long-term switch in gene expression, and thus determines cell fate. I report that...
The formation of neuronal inclusions is one of the hallmarks of neurodegenerative diseases. These structures are composed of aggregated proteins, molecular chaperones, and components of the ubiquitin-proteasome system (UPS). Co-localization of aggregated proteins with cell-homeostasis maintaining machinery indicates that the cell may be failing in an attempt to clear these...
The polymerization of the microtubule-associated protein, tau, into insoluble filaments is common to Alzheimer's disease (AD) and in a variety of dementias. The conformational change required for tau to transition from soluble monomers to filamentous AD pathology involves the extreme N-terminus of tau coming into contact with other regions of...
This dissertation is an ethnography that uses semi-structured interviews, field notes, and participant observation to explore how two religious congregations respond to survivors of domestic violence. I interviewed twenty-two parishioners including domestic violence survivors, clergy and bystanders. I transcribed these interviews verbatim using Agar's method of transcript handling. I used...