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- Description:
- The speed of the storage device has long lagged behind the computation speed of processors.As a result, the I/O performance of storage systems in a supercomputer fails to keep up with its computational power. This gap continues to widen in modern supercomputers. On future exascale supercomputers, this issue can worsen...
- Keyword:
- HDF5, NetCDF, Compression, Log, HPC, and Parallel I/O
- Subject:
- Computer engineering
- Creator:
- Hou, Kaiyuan
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 03/24/2023
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_948756 and http://dissertations.umi.com/northwestern:16383
-
- Description:
- Soft materials are inherently fluxional, with morphologies and behaviors that are dictated by their solvation state. Thus, many organic systems cannot be reliably imaged by static dry state or cryogenic-transmission electron microscopy (TEM). This motivated us to pursue liquid cell (LC) TEM method development to study our own materials and...
- Subject:
- Chemistry
- Creator:
- Korpanty, Joanna
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 03/24/2023
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16391 and etdadmin_upload_954956
-
- Description:
- CD95/Fas ligand (CD95L) is a well characterized activator of extrinsic apoptosis. CD95L protein binds to its cognate receptor, CD95/Fas/APO-1, inducing apoptotic signaling in sensitive cells. However, expression of CD95L is toxic even in the absence of CD95. We previously reported that the CD95L open reading frame (ORF) is enriched for...
- Keyword:
- FasL, RNA toxicity, RNA interference, and Cell death
- Subject:
- Molecular biology
- Creator:
- Haluck-Kangas, Ashley
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 03/24/2023
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16384 and etdadmin_upload_949365
-
- Description:
- Uranium is a unique, multifaceted element that possesses rich chemistry and promise for challenging reactions. Pressing demands within nuclear stockpile stewardship and the nuclear energy sector call for development of this relatively understudied element. Uranium metal–organic frameworks (U-MOFs), a class of nanoscale hybrid materials, harness the exceptional attributes of uranium...
- Keyword:
- metal-organic frameworks, uranium, and nanotechnology
- Subject:
- Inorganic chemistry, Nanoscience, and Chemistry
- Creator:
- Hanna, Sylvia Lorraine
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 03/24/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16404 and etdadmin_upload_961471
-
- Description:
- Over the past four decades, the rate of incarceration for women has risen significantly. Black women are disproportionately represented among incarcerated women. Formerly incarcerated women and men face similar barriers upon release from incarceration, such as obtaining stable and gainful employment, securing safe and affordable housing, and reconnecting with children...
- Keyword:
- black women, criminal justice, reentry, and incarceration
- Subject:
- African American studies, Criminology, and Sociology
- Creator:
- Banks, Erica
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 03/24/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16414 and etdadmin_upload_962304
-
- Description:
- Task-oriented conversational systems are becoming increasingly popular, as shown by the rise of conversational recommendation systems across multiple platforms (e.g., Google Home, Alexa, and Siri) and domains (e.g., local establishments, e-commerce, books, music, and movies). However, users are still largely limited in what preferences they can express and how, as...
- Keyword:
- conversational search, critiquing-based systems, language models, natural language processing, conversational systems, and conversational recommendation
- Subject:
- Artificial intelligence and Computer science
- Creator:
- S. Bursztyn, Victor
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 03/24/2023
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16403 and etdadmin_upload_961447
-
- Description:
- Motivated by rhythms in the brain, we investigate the synchronization of noisy and all-to-all pulse-coupled oscillators. We consider a case where the oscillatory excursions are of varying amplitude and where only sufficiently large excursions result in the output pulses that drive the interactions between the oscillators. In the regime of...
- Keyword:
- Oscillators, Markov Renewal, Events, Mixed-mode, Spiking, and Noise
- Subject:
- Applied mathematics
- Creator:
- Karamchandani, Avinash Jagdish
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 03/24/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16397 and etdadmin_upload_959050
-
- Description:
- Aging is the greatest known risk factor for Alzheimer’s Disease (AD); however, the molecular mechanisms underlying aging and how it can initiate and or exacerbate AD, is still unknown. Epigenetic regulation has been widely accepted to play an essential role in aging or AD-related processes; however, whether dysregulations of histone...
- Keyword:
- HDACs, Alzheimer's Disease, Epigenetics, and Aging
- Subject:
- Neurosciences
- Creator:
- McClarty, Bryan
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 03/24/2023
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_954939 and http://dissertations.umi.com/northwestern:16390
-
- Description:
- The retina detects light, processes the visual signal, and sends a complex set of parallel information channels to the brain via a functionally diverse set of retinal ganglion cells types. This manuscript examines these retinal ganglion cell types, the visual features they encode, and the computational mechanisms leading to their...
- Keyword:
- electrophysiology, computational, signal processing, Bipolar cell, Retina, and ganglion cell
- Subject:
- Ophthalmology and Neurosciences
- Creator:
- Swygart, David Isaiah
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 03/24/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_962145 and http://dissertations.umi.com/northwestern:16411
-
- Description:
- Human olfactory function is important for a myriad of behaviors, including food seeking, social cognition, memory, emotional regulation, and detecting environmental threats. In animal models, particularly dense olfactory inputs have been shown to target orbitofrontal cortex (OFC), a region involved in multimodal sensory integration, reward coding, and flexibly guiding our...
- Keyword:
- aging, tractography, olfaction, alzheimer's disease, orbitofrontal cortex, and diffusion magnetic resonance imaging
- Subject:
- Neurosciences
- Creator:
- Echevarria-Cooper, Shiloh Luela
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 03/24/2023
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16387 and etdadmin_upload_952134