Complex fluids are ubiquitous, from natural materials to manufactured products. Understanding their behavior under flow is vital for engineering these materials. Extensional flow, despite being industrially relevant and often producing dominant impacts upon complex fluids, is an underserved topic compared to shear flow due to a lack of reliable apparatuses...
This dissertation develops a new framework and algorithms for statistical process control of stochastic textured surface data that have no distinct features other than stochastic characteristics that vary randomly (e.g., image data of textiles or material microstructures and surface metrology data of metal parts). All methods are general and nonparametric...
Polymer nanocomposites are a class of advanced materials comprised of soft polymer matrix and nano-filler inclusions. While it has been found qualitatively that enhancements of material properties could be achieved by dispersing inorganic nano-particles into organic polymer matrix, the intrinsic governing principles of such composite has not been thoroughly studied...
Solvent-rich polyelectrolyte complexes display a wide range of rheological properties, when different environmental parameters are applied. Due to the low energy barrier of the complexation (~10 kT), these materials possess tunable properties, with the states of these materials varying from Newtonian liquids to very tough hydrogels. This thesis aims to...
NSD2, a histone methyltransferase specific for methylation of histone 3 lysine 36 (H3K36), exhibits a glutamic acid to lysine mutation at residue 1099 (E1099K) in childhood acute lymphocytic leukemia (ALL). Cells harboring this mutation can become the predominant clone in relapsing disease. We studied the effects of this mutant enzyme...
Some of the oldest drugs targeting metabolism are the antifolates such as aminopterin and methotrexate (MTX). MTX started being used in the 1950s to treat rheumatoid arthritis. Aminopterin and MTX both target one carbon metabolism and inhibit proliferation of cells. MTX was a potent inhibitor of inflammation, because it prevented...
Connecting structure and function in nanoscale engineered materials and devices relies on the analysis of the fundamental arrangement of matter, frequently under dynamic conditions. The demand to image structures at fundamental length scales has touched inorganic materials, biology, and frequently hybrid hard/soft materials with unique phenomena driven by heterogeneous components....
Cancer radiation therapy relies on optimized treatment plans whose quality assessment is judged by dosimetric planning aims. It is computationally prohibitive to incorporate the planning aims into the optimization models. Therefore, there exists a disconnect between the two steps of (1) optimizing a plan and (2) evaluating the optimized plan,...
In this dissertation, we study different machine learning algorithms including probabilistic, sparse and deep learning based models applied to multi-sensory datasets. In many machine learning problems, samples are collected from more than one source or modality. Also, various feature extraction methods can be used to provide more than one set...
Children are known to be curious and persistent question-askers. The pervasiveness of voice interfaces represents an opportunity for children who are still learning to read and write to independently search the Internet by directing questions at conversational agents such as Amazon’s Alexa, Apple’s Siri, and the Google Assistant. However, little...
The Controlled, Site-Isolated Synthesis of Polyelemental Nanostructures in Polymer Nanoreactors Pengcheng Chen Polyelemental nanoparticles are an attractive class of materials due to their potential applications, which span the fields of catalysis, plasmonics, electronics, magnetics, targeted drug delivery, and bio-imaging. However, conventional synthetic methods for such structures are limited, especially when...
This thesis focuses on the development of a cochlear implant (CI) that uses photons to stimulate surviving auditory neurons in severe-to-profoundly deaf individuals. The benefit of optical over electrical stimulation is its spatial selectivity with the potential to create significantly more independent channels to encode acoustic information and likely enhances...
Conventional methods in industrial organization assume that firms are strategically sophisticated and set prices as best responses to their competitive environment. In the first two chapters of this dissertation, I use a detailed dataset of retail and wholesale prices from the newly legalized cannabis industry in Washington state to show...
The National Rifle Association (NRA) is much more politically powerful than we might expect it to be. Despite both shockingly high rates of gun violence and deep, durable public support for stricter rules on gun ownership, the NRA regularly defeats or weakens the content of gun control legislation. Its influence...
Interleukin 33 (IL-33) is a complex inflammatory cytokine with diverse functions. In the context of cancer development, depending on the model, the implementation and dosage, and the immune cells involved, IL-33 can elicit dramatically different outcomes. Recent studies, including our own, have explored definitive contributions of the adaptive immunity in...
Metal-organic frameworks (MOFs) are a class of nanoporous materials with highly tunable pore shape and chemistry. They are synthesized in a "building block" approach to form crystalline porous materials, which have been explored for diverse applications including gas storage and separations. Given the enormous size of the MOF design space,...
A stroke occurs when blood flow in the brain is impaired and often causes damage to corticospinal tract projections that control the muscles of the upper-extremity. Due to this damage, 50-70% of stroke survivors experience long-term upper-extremity functional deficits(Faria-Fortini, Michaelsen, Cassiano, & Teixeira-Salmela, 2011). These deficits result from motor impairments...
This dissertation investigates long-term biographies of seventeen small medieval settlements in the region of Hegranes, Skagafjörður, North Iceland, placing their creation, development, and reuse in the context of coupled social and environmental change. The individuals and households who lived at the Hegranes sites were at the nexus of both kinds...
Data mining is multidisciplinary process involving computer science, artificial intelli- gence, and machine learning. The aim of data mining is discovering knowledge from a vast amount of data. This process consists of a set of stages forming a pipeline. This pipeline process consists of multiple steps: 1) Finding the right...
Hybrid pixel detectors, comprising of pixelated sensors coupled to readout integrated circuits (ROICs) with complex in-pixel processing, are essential for many of today’s scientific instruments and imaging systems. Large-area detectors are required in a variety of systems: from detectors for synchrotron beamlines to telescopes for astronomy, which range from a...