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Description:: Many transcription factors (TFs) regulate oncogenic processes and are therefore desirable targets for drug intervention. However, few TF inhibitors have been developed to date due to a lack of specificity and few TF binding pockets. The Meade Lab has overcome these challenges by using cobalt-based complexes that disrupt Cys2His2 zinc...
Keyword:: cellular delivery, zinc finger, hedgehog pathway, coordination complex, cobalt complex, and transcription factor
Subject:: Nanoscience, Molecular biology, and Chemistry
Creator:: Bajema, Elizabeth Amber
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/12/2020
Date Created:: 2018-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:14453 and etdadmin_upload_626420

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