Simple sensorimotor tasks, such as lifting a cup or balancing a tray, requires not only controlled motor output, but also the ability to accurately perceive sensory information. After a hemiparetic stroke, individuals often experience sensory deficits in addition to motor impairments. However, research on the extent of changes in sensory...
Voltage-gated potassium (KV) currents play a crucial role in shaping and controlling the firing patterns that serve as the fundamental basis for the differential signal processing from the ear to the auditory cortex, with distinct firing patterns observed with high- and low-frequency phenotypes. This is an interesting phenomenon, in the...
Situated at the intersection of literary, religious, and economic studies, this dissertation examines how late medieval writers used commercial practice to invent new modes of penitential piety. Challenging scholarship that characterizes the relationship between church and commerce as exclusively antagonistic or corrosive, I argue that the convergence of these two...
The speed of the storage device has long lagged behind the computation speed of processors.As a result, the I/O performance of storage systems in a supercomputer fails to keep up with its computational power.
This gap continues to widen in modern supercomputers.
On future exascale supercomputers, this issue can worsen...
Soft materials are inherently fluxional, with morphologies and behaviors that are dictated by their solvation state. Thus, many organic systems cannot be reliably imaged by static dry state or cryogenic-transmission electron microscopy (TEM). This motivated us to pursue liquid cell (LC) TEM method development to study our own materials and...
CD95/Fas ligand (CD95L) is a well characterized activator of extrinsic apoptosis. CD95L protein binds to its cognate receptor, CD95/Fas/APO-1, inducing apoptotic signaling in sensitive cells. However, expression of CD95L is toxic even in the absence of CD95. We previously reported that the CD95L open reading frame (ORF) is enriched for...
Uranium is a unique, multifaceted element that possesses rich chemistry and promise for challenging reactions. Pressing demands within nuclear stockpile stewardship and the nuclear energy sector call for development of this relatively understudied element. Uranium metal–organic frameworks (U-MOFs), a class of nanoscale hybrid materials, harness the exceptional attributes of uranium...
Over the past four decades, the rate of incarceration for women has risen significantly. Black women are disproportionately represented among incarcerated women. Formerly incarcerated women and men face similar barriers upon release from incarceration, such as obtaining stable and gainful employment, securing safe and affordable housing, and reconnecting with children...
Task-oriented conversational systems are becoming increasingly popular, as shown by the rise of conversational recommendation systems across multiple platforms (e.g., Google Home, Alexa, and Siri) and domains (e.g., local establishments, e-commerce, books, music, and movies). However, users are still largely limited in what preferences they can express and how, as...
Motivated by rhythms in the brain, we investigate the synchronization of noisy and all-to-all pulse-coupled oscillators. We consider a case where the oscillatory excursions are of varying amplitude and where only sufficiently large excursions result in the output pulses that drive the interactions between the oscillators. In the regime of...