The structure of the North American crust and mantle was investigated using P wave teleseismic tomography and the links between seismic tomographic models, locations of volcanism, sediment isopachs, and continental scale crustal structures via plate reconstruction modeling. Nearly 50,000 teleseismic P wave delay times were measured from seismograms recorded by...
Infidel(itie)s of Colour: Unruly Black Bodies, Modernity and Performance in Post-Apartheid South Africa focusses on the ways that queer and feminist artists of colour draw upon their traditional black cultural heritage and spiritual practises as a means of laying claim to cultural citizenship and belonging in post-apartheid South Africa. I...
Clustered regularly interspaced short palindromic repeats (CRISPR) and their associated Cas proteins provide an immune-like response in many prokaryotes against extraneous nucleic acids. CRISPR-Cas systems are classified into different classes and types that vary widely in composition, target recognition, and overall mechanism. The main division of CRISPR-Cas systems occurs between...
The focus of this thesis is on evaluating, designing, and applying statistical methods that elucidate molecular mechanisms by seeking to understand the pathways that contribute to disease. Chapter 1 introduces the field and motivates the work in this thesis. Chapters 2, 3, and 4 describe original work. Chapter 5 recapitulates...
The halide perovskites AMX3 (A = large cation, B = Sn or Pb, and X = halide) have been the subject of intense investigation due to their outstanding optical and electronic properties, which have enabled high solar cell efficiencies thanks to a beneficial electronic structure and long charge carrier lifetimes....
Motor planning is fundamental to the performance of everyday reaching movements. The influence of planning is not limited to voluntary movements but extends to involuntary movements initiated in response to sensory stimuli, such as postural perturbations applied to the arm. Stroke alters voluntary reaching and the involuntary response to perturbations,...
This dissertation concerns the probabilistic aspects of diffusion processes generated by a family of differential operators, which is similar to the family of hypoelliptic Laplacian operators, acting on the tangent bundle of a compact Riemannian manifold. By lifting the processes to the product of the frame bundle and the euclidean...
Despite improvements to diagnostics and treatment methods, colorectal cancer remains the second leading cause of cancer death in the United States. Colonoscopies, the gold standard for colorectal cancer screening, can significantly increase the patient’s chance of survival through early detection. However, colonoscopy cost, surgical complications, and patient bowel preparations limit...
This dissertation is a wide-ranging study on real estate and the effect of financial constraints on economic activity. In the first chapter, I use granular data on home builder housing developments to provide new evidence that firms spread negative revenue shocks across projects via their internal capital markets. I analyze...
This dissertation explores the interrelationship between time, labor, and literature during the rise of British industrial capitalism. By tracing a tradition of social criticism from Percy Shelley to William Morris that runs through the Chartist movement, Thomas Carlyle, and Charles Dickens, it isolates and explicates a distinctive existential mood, or...