Characterization is the musical creation of fictional characters, and it is particularly important for creating multi-dimensional, nuanced characters in opera. However, how do composers characterize roles if the opera does not feature a traditionally linear plot or story? Does opera need a narrative to create characterization? Some may view narrative...
The challenges of using inadequate online recruitment systems can be addressed with
machine learning and software engineering techniques. Bi-directional personalization
reinforcement learning-based architecture with active learning can get recruiters to recommend
qualified applicants and also enable applicants to receive personalized job recommendations.
This paper focuses on how machine learning...
Prostate cancer is the most common cause of cancer among men in the United States, and the second most common cause of cancer-related death, accounting for significant morbidity and mortality. This dissertation describes the genomic landscape of prostate cancer from multiple angles to identify mechanisms of disease heterogeneity amongst patients....
Current technologies capable of establishing bioresorbable orthopedic fixation devices and stents have broad utility for biomedical applications to improve constructive tissue remodeling. Recent studies and investigations on bioresorbable conductors, semiconductors, dielectrics, and polymer substrates offer a promising opportunity to propel the existing non-degradable bioelectronic devices to the promising bioresorbable electronics,...
The intersection of sound design and music scoring has been employed expressively in contemporary Mexican cinema to convey complex social commentary. This dissertation investigates how the Mexican films Vuelven, Sin Señas Particulares, and Sanctorum exploit the potentials of the soundtrack to create politicized aesthetic experiences. My research is in dialogue...
Body size is one of the most discernible ways in which animal species vary. The blue whale (Balaenoptera musculus), the largest animal on earth, can reach up to 30 m in length and weigh up to 200 tonnes. At the other extreme, a species of frog called Paedophryne amauensis is...
Cell-based therapies are an exciting frontier in medicine. This field is built on a simple premise—cells can be engineered to recognize and treat various human diseases. The paradigm of cell-based therapy uses biosensors to interrogate a cell’s environment and distinguish disease from health, intracellular signaling pathways and genetic circuitry to...
Electrochemical cell devices are increasingly being sought for energy conversion and storage applications due to their high efficiencies and their potential for operating free of greenhouse gas (GHG) emissions. Solid Acid Electrochemical Cells (SAECs), which most commonly employ CsH2PO4 (CDP) as the electrolyte component, are uniquely suited to meet the...
Migrant illegality gives way to irregular livelihoods in Spain and around the world. Studies on migrant illegality have generally focused on its political, legal and economic production and the social impact of a states specific biopolitics. While invaluably important, there remains the need to better understand the modes of life...
Plasminogen activator inhibitor-1 (PAI-1) is an essential mediator of senescence and a potential therapeutic target for preventing aging-related pathologies. Cellular Senescence is associated with organismal aging and related pathologies. In our study, we investigate the efficacies of PAI-1 inhibitors in both in vitro and in vivo models of homocysteine...
This dissertation examines how China’s involvement in transnational LGBTQ activism, adaptation and innovation of queer media technologies, and the global pink economy have influenced queer men’s understandings of selfhood, sexual desires, and the relationships among queer subjects. It is based on extensive fieldwork in Beijing and digital ethnography on China’s...
Living organisms undergo morphogenesis as they develop and change shape to fit their evolved niche in natural ecosystems. The biological processes underlying morphogenesis involve sophisticated feedback loops between spatiotemporal release of morphogenic molecules that diffuse and signal cell differentiation, as well as contextual interaction with the physical surroundings of the...
Assistive robotics focuses on human-robot systems that provide physical support and assistance to the elderly and people with motor-impairments. While assistive machines, such as the powered wheelchair, can significantly enhance the functional independence of individuals, many users are challenged by their direct operation, the manner in which such systems are...
Many theories of categorization have included an intuitive role for our ability to detect and judge similarity. Yet, this important role of similarity processing has been disputed. This research adopts a model of similarity processing through structure mapping (Gentner, 1983) to explore its role in similarity processing and categorization. Relational...
This dissertation examines the behavior of bare singular noun phrases, a set of English nominals showing no formal indication of either definiteness or mass/ count status. Although they appear to be count nouns, I show that these nominals represent maximal projections.
Lubrication is the most means for sliding interface failure prevention because it helps separate two interacting surfaces, reduce asperity contacts and thus extend the working life of the parts. Improving the tribological performance of lubricated interfaces is a challenging work, as several influence factors are involved, such as coating, plasticity,...
This paper examines the vocal works of Pelle Gudmundsen-Holmgreen in an effort to establish that, despite their technical difficulty and apparent complexity, these pieces are actually rooted in the Danish New Simplicity (Ny Enkelhed) aesthetic. It also provides biographical, historical, and cultural context for those who are interested in performing...
This dissertation aims to redefine the concept of pain as it appears in literary studies and demonstrate how the new definition garners insight into the interwovenness of literature and physiology in the mid-eighteenth century. It challenges the claim that pain is opposed to language by adopting a new materialist concept...
This dissertation explores performance as a mechanism of racialization and politicization of Native Americans in the United States. I analyze performances of Indians on theatrical stages to define how an embodied repertoire of visual, aural, and kinetic markers, what I call the Stage Indian, became codified and circulated within popular...
Early Modern Matters of Life and Death” argues that the political ecology of living, dead, and (in)animate beings in early modernity elucidates the claims of humanism and human exceptionalism that evolved in the period and that still inform present-day anthropogenesis
Since their introduction nearly a century ago, protein vaccines and therapeutics have revolutionized our ability to prevent and treat human disease. However, existing production processes for biopharmaceuticals are technically complex and rely on living cells, which necessitates highly centralized manufacturing in large-scale production facilities, specialized equipment, and cold-chain distribution. With...
In 2008, the term "remix culture" is widely understood to refer to mash-up videos and movie parodies, distributed on websites such as YouTube and authored primarily by white male teenagers. This dissertation argues that digital remix was invented primarily by African American men, who, in the mid-1980s, began using digital...
This project examines the uneven adoption of therapeutic initiatives within the organizational field of American museums to ask: How do people frame museum-going as “good” for visitors’ health? Existing research on legitimation processes would predict cultural institutions respond similarly to pressures for greater accountability from their external environments, or resist...
X-ray Fluorescence Microscopy (XFM) is a useful technique for study of biological samples. XFM was used to map and quantify endogenous biological elements as well as exogenous materials in biological samples, such as the distribution of titanium dioxide (TiO2) nanoparticles. TiO2 nanoparticles are produced for many different purposes, including development...
This dissertation is an ethnography that investigates how Chicago-based artists and organizations use hip-hop performance as a tool for grassroots education and communal dissent. By exploring these local artistic approaches, this research reveals the salience of hip-hop performance in cultivating social movements, embodied politics, and choreographic repertoires that respond to...
Erythropoietin-producing human hepatocellular (Eph) receptors and their corresponding ephrin ligands are asymmetrically expressed at cell-cell contacts allowing for bidirectional signaling with forward signaling through the receptor expressing cell and reverse signaling through the ligand expressing cell. Eph receptors are the largest family of receptor tyrosine kinases (RTKs) in mammals, which...
Memory systems research has established the importance of two distinct types of memory systems in the brain: explicit and implicit. While a robust literature exists on individual differences in the explicit domain (Chapter 3), research on individual differences in implicit learning remains relatively limited. The key question guiding the investigation...
Individual plasmonic nanoparticles have the potential to revolutionize all areas of energy science, catalysis, organic electronics, and solar technology. Owing to their light trapping and focusing ability, single nanoparticles can be utilized to efficiently drive chemical reactions at the sub-nanometer scale. Much of the fundamental science regarding how plasmons can...
This dissertation endogenizes information acquisition in two-player games across three different settings. The first chapter explores when moral hazard in a principal-agent contract can lead to pareto improvements when it is preceeded by information gathering. The second chapter studies how product differentiation affects the amount of market research done by...
This thesis studies the in-hand manipulation problem of repositioning finger contacts on an object by controlled sliding. In this thesis we investigate two versions of the problem. First for a multifingered hand with circle patch contacts, we present a framework for planning the motion of the hand to create an...
The work of this dissertation seeks to enhance the understanding of DNA-driven nanoparticle assembly and introduce kinetic routes to control mesoscale crystal habit and size. Chapter 1 describes the state of the art in the field of nanoparticle assembly and, specifically, DNA- mediated nanoparticle assembly, where the concept of a...
In this dissertation, I argue that the locus of Tsvetaevaseemingly conflicted views about art and the criteria for its evaluation is the tension between the rational, ethical, and distinctively human in us, and the irrational spontaneous impulse. Tsvetaevaterm for the irrational impulse is stikhiia, a force of nature that is...
Over the past decade significant advancements have been made across the field of cancer biology resulting in transformative new therapies. Despite these advancements, treatments for metastatic cancer remain relatively ineffective. Metastasis is coordinated by various types of “healthy†stromal cells in addition to the tumor cells themselves. This requires a...
Let X,Y be algebraic varieties defined over the reals. Assume Y is smooth and X is Gorenstein. Suppose f:X -> Y is a flat R-morphism such that all the fibers have rational singularities. We show that the pushforward of any smooth, compactly supported measure on X has a continuous density...
Ubiquitous in the environment are bacteria that have evolved to adapt to the environmental niches they colonize. To this end, bacteria sensory and signaling molecules are required for processing these extracellular changes within their environment into changes in gene expression. The plague-causing pathogen, Yersinia pestis, contains a repertoire of two-component...
Nano-scale materials possess many unique physical and chemical properties which are not found in bulk materials. The ability to synthesize these materials by design is one of the greatest challenges in materials science. Advances towards meeting this challenge will lead to discoveries in fields such as plasmonics, photonics, catalysis, and...
Ectomycorrhizal (ECM) fungi are a group of cosmopolitan symbiotic soil fungi that colonize the fine roots of tree species and play an essential role in plant nutrition and ecosystem function. In worldwide afforestation projects, the establishment of introduced trees in novel habitats has been shown to require ECM fungal associations....
I study three topics in applied microeconomics. My first chapter concerns the effect of daily school start times on academic achievement in Florida. Exploiting the sharp discontinuity in school start time relative to sunrise, I track children who move between schools on either side of the time zone boundary in...
Journalism professionals and researchers have recently argued that newsrooms adopt audience engagement as one of their chief pursuits. This term has many interpretations that stem from one underlying belief: journalists better serve their audiences when they explicitly focus on how their audiences interact with and respond to the news in...
Supported metal oxides are an important class of heterogeneous catalysts active for many selective oxidation reactions including alkane oxidative dehydrogenation. Attempts to develop fundamental structure-function relationships for supported metal oxide catalysts for alkane oxidative dehydrogenation have been challenging, with many conflicting reports in literature. This has been in part due...
Convent education was financially accessible to many girls whose families could not afford a private tutor and nuns were the largest group of educated, culturally-active women in pre-modern Europe. Convent education mirrored the general contours of humanist education by associating learning with morality, serving the purposes of the Venetian republic,...
Through an engagement with the work of American postmodern choreographers Anna Halprin, Yvonne Rainer, and Laura Dean, I expose choreographic legacy as an ongoing process of continually rewriting dance history. Halprin, Rainer, and Dean’s models for choreographic transmission draw from the legacy methods of repertoire, reconstruction, and reperformance, while simultaneously...
Students often change majors during college, and most workers change jobs throughout their careers. Yet the diverse opportunities for entering natural science, technology, engineering, and mathematics (STEM) fields are often overlooked during college and beyond. This dissertation therefore analyzed four large nationally representative datasets to characterize the pathways for joining...
We compare two different methods to compute the mod 2 homology of an infinite loop space. One method is to approximate the infinite loop functor using functor calculus. The other is to approximate the spectrum using an Adams resolution. We show that these two ways lead to isomorphic spectral sequences....
œRuling Sexuality: Law, Expertise, and the Making of Sexual Knowledge, brings together approaches from the sociologies of science, law, and sexualities to examine how the institutions of law and science jointly render sexual subjects legible to state institutions by measuring and categorizing sexualities. Through the comparative study of asylum claims...
The mammalian retina harbors more than 30 output channels, each playing a distinct role in processing visual images. A comprehensive understanding of the retinal code primarily relies on the functional knowledge of individual output neurons or retinal ganglion cells (RGCs). Despite recent technical advances in imaging and genetics, the function...
Raising California Together, an ethnography of licensed family childcare homes, contributes significant theoretical and empirical knowledge to our understanding of workfare, immigration and education institutions that shape the lives of the youngest subject-citizens and of those who care for them. I draw from more than three years of participant observation...
Scholars frequently use the term œhymn-like to describe passages of instrumental music but the precise meaning of the term remains elusive. This dissertation examines, through the lens of topic theory, the characteristics, origins, and communicative potential of such passages in the music of the late-eighteenth and early-nineteenth centuries. I define...
My dissertation draws on Heideggers interpretation of Kant to argue that Kant overestimates the role that causality plays in structuring our experience. Heidegger suggests that Kants analysis of experience mistakenly universalizes a fraction of our experience: the experience of material things. I defend the merits of this suggestion by offering...