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Description:: This thesis proposes a robust multi-pronged approach to study the effect of nanoparticles on cells. In the first place, this work is focused on investigation of the protein corona that accumulates on the surface of nanoparticles internalized by the cells and their poly-pathway effects on protein availability and messenger RNA...
Keyword:: PARP, Nanoparticles, BIRC5, XFM, and SR-FTIR
Subject:: Nanotechnology, Biology, and Biochemistry
Creator:: Lastra, Ruben Omar
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 10/07/2021
Date Created:: 2021-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_837951 and http://dissertations.umi.com/northwestern:15671

Description:: Gold nanoparticles (AuNPs) display unique characteristics compared to their macro-counterparts that are dependent on shape, size, and attached surface molecules. Methods have been developed to precisely control both size and shape of AuNPs for specific applications. The biocompatibility, plasmonic properties, and ease of functionalization with thiolated molecules, make gold nanoparticles...
Keyword:: gold nanopaticles, therapeutics, DNA, cancer vaccine, and plasmonics
Subject:: Nanotechnology, Chemistry, and Biology
Creator:: Coughlin, Emma
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 06/28/2021
Date Created:: 2021-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:15532 and etdadmin_upload_815702

Description:: Over the past fifty years, techniques for synthesizing and manipulating matter on the 1-100 nanometer scale have led to the development of nanoparticle-based approaches to both disease diagnosis and treatment. The modification of nanoparticles with biological macromolecules such as proteins and nucleic acids has led to the development of highly...
Keyword:: Spherical Nucleic Acid, Anthrax, Aptamer, NanoFlare, Gold Nanoparticle, and CRISPR
Subject:: Nanotechnology, Bioengineering, and Biology
Creator:: Larkin, Isaac Nathaniel
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/01/2021
Date Created:: 2020-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:15186 and etdadmin_upload_754966

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