Demand Response (DR) is an approach that allows electricity users to actively participate in keeping supply-demand balance in power systems, or its future version, smart grid, in order to increase the system efficiency, lower consumers' electricity bills, and thus improve social welfare. To encourage users' participation in DR, a time-varying...
This integrated dissertation focuses on the relationship between family functioning (including marital conflict, family conflict, and parental depression), youth depression, and long-term functioning of adolescents who were treated for depression. This dissertation consists of three distinct studies: a meta-analytic study of the relationship between marital conflict and youth depression and...
Metal–organic frameworks (MOFs) are a class of crystalline materials composed of metal nodes connected by organic linkers. Due to their high degree of synthetic tunability, MOFs have been considered for a wide range of applications, including many that rely on a change in oxidation state. While most MOFs are generally...
Theory of mind (ToM) reasoning is defined as the ability to reason about another’s internal states, such as beliefs, goals, and desires. It is a major aspect of human social interaction and is mastered by most typically developing children by age five. On the other hand, simulated agents generally lack...
In this dissertation, we study different machine learning algorithms including probabilistic, sparse and deep learning based models applied to multi-sensory datasets. In many machine learning problems, samples are collected from more than one source or modality. Also, various feature extraction methods can be used to provide more than one set...
Renewable energy technology, more so than ever before, is critical to the survival of humanity. For decades, concentrated efforts into designing and developing such novel devices resulted in the innovation of solar-driven photovoltaics that were competitive with nonrenewable alternatives. This thesis explores the dynamic behavior of alternative material candidates that...
Since its introduction as an artist’s pigment in the earth 20th century, titanium white has become one of the most common white pigments. The early formulations of titanium white contained anatase, which has been studied to facilitate degradation of oil paint under UV illumination. Around the 1940s production shifted to...
Children are known to be curious and persistent question-askers. The pervasiveness of voice interfaces represents an opportunity for children who are still learning to read and write to independently search the Internet by directing questions at conversational agents such as Amazon’s Alexa, Apple’s Siri, and the Google Assistant. However, little...
The work presented in this thesis is to describe the fabrication of the nano-composites of carbonaceous materials (e.g. graphene oxide) and metal oxides (e.g. Titanium dioxide TiO2) for two specific applications in the field of public health protection: 1.) removal of micropollutants (MPs) in the aqueous environment; 2.) antimicrobial coating.The...
The Controlled, Site-Isolated Synthesis of Polyelemental Nanostructures in Polymer Nanoreactors Pengcheng Chen Polyelemental nanoparticles are an attractive class of materials due to their potential applications, which span the fields of catalysis, plasmonics, electronics, magnetics, targeted drug delivery, and bio-imaging. However, conventional synthetic methods for such structures are limited, especially when...
The need for complex and sophisticated materials continues to grow as society becomes more advanced. For many chemists, the design of these materials begins by looking towards model molecular systems for the identification of desirable properties and functions. As such, restricting oneself to C, H, N, O, and the other...
The current view in neuroscience holds that the brain, together with its sensory and motor structures and the environment, form a closed-loop system – a sensorimotor loop – in which the brain receives information from the environment and converts it into a motor response while simultaneously making predictions about future...
As technology scales down, challenges in fabrication, thermal stress, and in-field degradation have put the reliability of processors at risk. Among different fault types, transient faults manifest themselves frequently due to high chip density, aggressive voltage scaling, and high clock frequency. Some dependable processor architectures have been proposed to counter...
Computational material engineering (CME) has increased the pace of material development many folds in recent years by taking advantage of computational tools such as using simulations as replacement to experiments, and building complicated processing-structure-property relationships using advanced machine learning tools. The importance of CME is underscored by new computation-based design...
Polymers with electrolyte groups or “polyelectrolytes” have been the subject of intense study for the past few decades due to characteristics such as anti-fouling and underwater adhesion. Because of their charged nature, however, polyanions and polycations will complex in aqueous solutions forming dense unprocessable precipitates. In an attempt to leverage...
Anxiety and depression are highly prevalent, recurrent, and major public health problems. Decades of research has uncovered associations between symptom dimensions of anxiety and depression and abnormal neural activation across executive control-, threat-, and reward-related networks. Recent studies have developed a hierarchical symptom structure of anxiety and depression termed the...
This thesis focuses on the development of a cochlear implant (CI) that uses photons to stimulate surviving auditory neurons in severe-to-profoundly deaf individuals. The benefit of optical over electrical stimulation is its spatial selectivity with the potential to create significantly more independent channels to encode acoustic information and likely enhances...
Conventional methods in industrial organization assume that firms are strategically sophisticated and set prices as best responses to their competitive environment. In the first two chapters of this dissertation, I use a detailed dataset of retail and wholesale prices from the newly legalized cannabis industry in Washington state to show...
The development of functional materials with rationally designed hierarchical structure is an interdisciplinary challenge. Looking to nature for inspiration, we use small molecules that
engage in directed self-assembly through carefully tuned intermolecular interactions to construct
materials that have structure at multiple length scales. In this work, supramolecular structures
formed using...
The purpose of this study was (1) to examine the impact that small ensemble free improvisation experiences had on dispositional empathy development when compared with other forms of collective music making; and (2) to examine the relationship between co-performing musicians’ empathy levels and their performance achievement in small ensembles using...
Each neuron in the primary motor cortex (M1) is like a musician in an orchestra, contributing to a larger harmony under the constraint of a “neural manifold”—a geometric score describing the correlated signals produced by the neural musicians that drive movement. Despite the widespread recognition of the importance of M1...
The National Rifle Association (NRA) is much more politically powerful than we might expect it to be. Despite both shockingly high rates of gun violence and deep, durable public support for stricter rules on gun ownership, the NRA regularly defeats or weakens the content of gun control legislation. Its influence...
Radiofrequency ablation is a minimally-invasive treatment method that aims to destroy undesired tissue by exposing it to alternating current in the 100 kHz to 800 kHz frequency range and heating it until it is destroyed via coagulative necrosis. Ablation treatment is gaining momentum especially in cancer research, where the undesired...
The dynamics of human joints are fundamental characteristic of the human motor system, and altered joint impedance can hinder mobility. Individuals with transtibial amputation typically experience slower and energetically costly gait, while individuals with chronic stroke experience persisting gait deficits arising from spasticity, hypertonia and paresis. Investigating joint impedance of...
Every music theorist has their own personal reasons for engaging in the craft of theorizing about music. Many discover that there is something special about a theoretic disposition which differs from other sorts of interactions with music. It is often this special something that draws musicians into the discipline: specifically,...
Recognizing the significance of social interactions in shaping human behavior and development, policies and programs often rely on peers and social relationships as mechanisms for inducing positive change. Yet, even in randomized control trials, social spillover can make an effective program appear ineffective, and measuring peer effects poses identification...
Interleukin 33 (IL-33) is a complex inflammatory cytokine with diverse functions. In the context of cancer development, depending on the model, the implementation and dosage, and the immune cells involved, IL-33 can elicit dramatically different outcomes. Recent studies, including our own, have explored definitive contributions of the adaptive immunity in...
NiTi shape memory alloy (SMA) has drawn a great deal of attention for its various applications in the medical field (orthodontics, cardiovascular stents technology, etc.) and in other engineering fields (aerospace, aircraft, automotive, etc.) as it shows shape memory effect, superelasticity and biocompatibility. The fatigue-related issues, however, are pronounced in...
When properly regulated, inflammation leads to the recruitment and activation of circulating leukocytes to maintain and restore tissue homeostasis. Although this process is critical for successful wound healing and the elimination of pathogens and infections, misdirected inflammation can exacerbate pathology and cause substantial morbidity and mortality. Inflammation a fundamental process...
Metal-organic frameworks (MOFs) are a class of nanoporous materials with highly tunable pore shape and chemistry. They are synthesized in a "building block" approach to form crystalline porous materials, which have been explored for diverse applications including gas storage and separations. Given the enormous size of the MOF design space,...
A stroke occurs when blood flow in the brain is impaired and often causes damage to corticospinal tract projections that control the muscles of the upper-extremity. Due to this damage, 50-70% of stroke survivors experience long-term upper-extremity functional deficits(Faria-Fortini, Michaelsen, Cassiano, & Teixeira-Salmela, 2011). These deficits result from motor impairments...
This dissertation investigates long-term biographies of seventeen small medieval settlements in the region of Hegranes, Skagafjörður, North Iceland, placing their creation, development, and reuse in the context of coupled social and environmental change. The individuals and households who lived at the Hegranes sites were at the nexus of both kinds...
Interpenetrating polymer networks (IPNs) are multicomponent materials that enhance the compatibility of otherwise immiscible polymers by trapping the microstructure in a non-equilibrium state. By combining polymers with vastly different moduli, IPNs effectively disperse rigid polymers within a soft matrix, resulting in a reinforced elastomer. This approach significantly increases the modulus...
Large scale adoption of sustainable technologies for energy productionand storage can be greatly facilitated by scientific advances impacting efficiency, cost and availability. The study of materials is instrumental in both upgrading the performance of existing technologies and enabling the development of new ones, and ab-initio methods and machine learning represent...
Chronic stress is a significant risk factor for the development of numerous psychiatric disorders, including major depressive disorder (MDD). Individuals with MDD exhibit impairments in reward processing and decreased motivation to engage in previously-rewarding activities. Importantly, there is a large sex disparity in MDD diagnosis, such that it affects nearly...
This thesis investigates various aspects of productivity. In the first chapter I investigate the role of consumer demand in generating productivity dispersion. In particular, I study how differences in consumer preferences across the household income distribution generate dispersion in markups across the Indian manufacturing sector. I find that this consumer...
Christian artists use dramatic license and theatrical representation to mold idealized versions of the Bible into recreational spaces for popular consumption, such as immersive theaters, theme parks, and museums. For these Christian artists, the impulse to evangelize through theatrical representation overcomes deeply ingrained religious sentiments of antitheatricality and result in...
From energy to materials, hydrocarbon chemistry drives our world. Stemming from the petrochemical industry, our understanding of CxHy combinations has allowed society to flourish, and hydrocarbons will likely remain valuable species in our future even as we transition to greener carbon and hydrogen sources. Currently, one of the most efficient...
Data mining is multidisciplinary process involving computer science, artificial intelli- gence, and machine learning. The aim of data mining is discovering knowledge from a vast amount of data. This process consists of a set of stages forming a pipeline. This pipeline process consists of multiple steps: 1) Finding the right...
The high-temperature oxidation/reduction behaviors of iron and its oxides are important to a variety of energy conversion and storage technologies, such as the solid-oxide iron-air battery and chemical looping combustion. The useful lifetime of iron redox materials is limited, however, by structural degradation arising from (i) sintering, accelerated by phase...
High performance polymers and their composites have wide ranging application in advanced and emerging material systems. The macroscale performance of these advanced materials is often defined by interfaces that induce nanoscale changes in the microstructure or molecular conformations (termed the ‘interphase’) of the polymer. Atomic force microscopy (AFM) is an...
Hybrid pixel detectors, comprising of pixelated sensors coupled to readout integrated circuits (ROICs) with complex in-pixel processing, are essential for many of today’s scientific instruments and imaging systems. Large-area detectors are required in a variety of systems: from detectors for synchrotron beamlines to telescopes for astronomy, which range from a...
Efficient and sustainable utilization of global resources represents a grand but achievablechallenge. By leveraging biology, we can transform abundant, but recalcitrant resources like lignin
to products ranging from fuel to medicine to polymers. Efforts to do so are expansive, but
challenges remain, due in no small part to the difficulty...
Chapter 1: Despite the rapid growth of passive ownership over the past 30 years, there is no consensus on how or why passive ownership affects stock price informativeness. This paper provides a new answer to this question by examining how passive ownership changes investors' incentives to acquire information. I develop...
Engineering responses of soft materials at hierarchical time and length scales is of great interest to both fundamental science and technological applications. In recent years, the hybridization between emerging soft condense matters and conventional hard condense matters keeps enriching the materials library of humankind and opens another largely-uncharted venue for...
The nonlinear attributes of cochlear function are fascinating. Responses are compressed with surprisingly little distortion, different stimuli interact in competitive ways, and tones are created either with or without acoustic stimulation. Moreover, because of their dynamism, these nonlinear phenomena have provided an invaluable means for noninvasively probing and understanding cochlear...
Bioelectronic devices at the biotic/abiotic interface face a number of key challenges that include device degradation when exposed to biological fluid, their elicited immune response due to mechanical mismatch, and poor signal transduction. Organic electronic materials and their devices, such as organic electrochemical transistors (OECTs) address these shortcomings. They can...
4D Flow MRI is a phase-contrast magnetic resonance imaging method that enables direct measurement of velocities in three orthogonal directions throughout the heartbeat. This permits direct quantification of hemodynamic parameters, including flow, mean velocity, peak velocity, and pulsatility, for individual cerebral vessels. Despite ongoing research into neurovascular applications of 4D...
Predicting pediatric spinal deformity (PSD) from X-ray images collected on the patient's initial visit is a challenging task. This research provides a bio-informed framework based on a mechanistic machine learning technique with dynamic patient-specific (PS) parameters to predict PSD. We provide a geometry-based bone growth model that can be utilized...
We consider constant scalar curvature K ̈ahler metrics on a smooth minimal model of general type in a neighborhood of the canonical class, which is the perturbation of the canonical class by a fixed K ̈ahler metric. We show that sequences of such metrics converge smoothly on compact subsets away...
Abstract Kaposi sarcoma (KS) is the most common cancer associated with human immunodeficiency virus/ Acquired Immunodeficiency Syndrome (HIV/AIDS) infection worldwide and it is the most prevalent cancer in some countries in sub-Saharan Africa (SSA). The introduction of combination antiretroviral therapy (ART), led to dramatic declines in KS morbidity and mortality,...
This dissertation contains four essays. The first essay, Strategically Giving Service: The Effect of Real-Time Information on Service Efficiency, analyzes the impact of the increased availability of real-time information on the behavior of strategic agents and the implications of this phenomenon for service efficiency using data from one of the...
Localized corrosion involves the selective attack of a metal at a small, exposed site. This can be particularly devastating for load-bearing structures like bridges, which can fail catastrophically even with very little material loss. Unfortunately, such corrosion is very hard to prevent, predict, and detect. Corrosion can be prevented by...
Records of temperature and precipitation during Quaternary interglacial periods on Greenland are notably scarce, limiting assessment of the magnitude and rate of local environmental response to orbitally-driven Arctic warming. It is largely unknown if warming across Greenland was spatially uniform through past interglacials, and if warming was accompanied by major...
Solid acid fuel cells confer unique advantages over nearby technologies, such as polymer electrolyte membrane fuel cells (PEMFCs) or solid oxide fuel cells (SOFCs), due to the solid acid electrolyte – a solid-state, anhydrous, intermediate-temperature proton conductor.Despite these encouraging unique properties, solid acid fuel cells have performed unfavorably in comparison...
In solar energy conversion ranging from artificial photosynthesis to photocatalysis, transition metal complexes (TMC) are essential building blocks due to several attractive properties: intense absorption within the solar spectrum, presence of charge-transfer excited state, and substrate binding capability through coordination geometry changes. In order to gain insight into controlling solar...
In this thesis, I explore the formation and evolution of neutron stars and millisecondpulsar populations in globular clusters using N-body simulations. In particular, I examine how the number of millisecond pulsars and the pulsar properties, including binary
properties and different pulsar types, depend on the dynamical cluster environment. I
demonstrate...
Movement and sensing fundamentally works in a synergistic manner. Animal's sensory organs --- be they independently movable like eyes or requiring whole body movement as in the case of electroreceptors --- are actively manipulated throughout stimulus-driven active sensing behaviors. Though these sensing-related motions have been individually reported and analyzed across...
Recent development on optogenetic methods offers reliable path to modulate cell activities with high level spatiotemporal precision. Application of this technology in behavior studies significantly improves our understanding in the neural principle that underpin animal behaviors, including ourselves. Full exploitation of optogenetic method in neuroscience behavior studies relies on...
Situated at the intersection of literary, religious, and economic studies, this dissertation examines how late medieval writers used commercial practice to invent new modes of penitential piety. Challenging scholarship that characterizes the relationship between church and commerce as exclusively antagonistic or corrosive, I argue that the convergence of these two...
“(Being a) Feminist (is a) Struggle: Intersectional Feminist Politics in the Era of the Women’s March” argues that contemporary feminist politics are characterized by debates and contestations concerning the political demands of intersectionality. Contemporary feminist theory and politics are particularly and peculiarly preoccupied with making these judgements about the political...
Proteins represent a critical class of biomolecules, universally employed by all living organisms to fulfill essential structural, functional, and enzymatic roles necessary to support life. In nature, these polymers are composed generally of twenty natural amino acid (AA) building blocks, which can be modified with covalent adducts known as post-translational...
Methanotrophs, bacteria that can metabolize methane, remain a promising solution to mitigating the effects of climate change by removing atmospheric methane and converting it to useful chemical precursors. However, a full understanding of the main enzyme they use to oxidize methane, particulate methane monooxygenase (pMMO), is critical for harnessing their...
Despite prevention and treatment, substantial risk for cardiovascular disease(CVD) remains in the population and CVD has been the leading global cause-of-death in past years.While high-density lipoprotein (HDL) markers such as HDL cholesterol (HDL-C) and HDL efflux (a cholesterol-transport-function assay) are associated with decreased risk of CVD, the mechanism of this...
This dissertation imagines the near future of teamwork, when AI agents will join teams,interacting, collaborating, and completing tasks as a team member. Broadly, I seek to answer the
questions: how do humans integrate a new AI teammate onto their team, and how does the AI
teammate’s function influence this integration...
This dissertation present a Compound Poisson Mixture Regression model of the distribution of transaction frequency and monetary value, and apply it to study donations at a private university in the Midwestern United States. The model captures the joint effect of covariates, recognizing that both response variables emanate from one statistical...
Many estimation and inference procedures rely on asymptotic approximations for quantities that are unknown to researchers. While often convenient, such approximations can be poor in practice, even when the number of observations is ostensibly large. One response is to eschew asymptotics in favor of finite sample bounds. While remarkable progress...
This dissertation researches the Cenomanian, Turonian, and Coniacian Stages (100.5 - 86.3 Ma) of the Cretaceous Period, a geologic interval of interest due to its extreme global warmth, iconic faunas, and oceanic anoxic events (OAEs). Five globally dispersed geochemical and stratigraphic case studies reconstruct interactions of the mid-Cretaceous carbon cycle...
This dissertation examines the following puzzle: Why have antitrust (competition) laws and policies failed in their mission to prevent concentrations of economic power globally? Corporate monopolization has grown more acute in the last three decades and created serious problems in consumer and worker protection, economic stability, and democratic representation worldwide....
This dissertation contains two chapters. The first one is on microenterprises in developing countries and how they face competition from large corporations. The second one is on estimating the causal effect of childcare availability on the formation and persistence of gender gaps in the Mexican labor market. The first chapter...
How do ever-changing international systems and rapidly emerging technology shape counter-systemic revolutionary insurgent (CSRI) behavior and outcomes? The purpose of this publication is to identify causes and develop a conceptual typology of CSRI survival and behavior in a Post-9/11 era. I argue three global shocks acted as junctures for new...
This dissertation explores the relationship between cultural production in Puerto Rico from 2005 to the present and the unfolding debt crisis on the island. I explore the relationship between colonialism as an institution, coloniality as a broader structuring of power, and the current debt crisis by examining cultural objects that...
Affect represents a major domain of human consciousness, consisting of a complex group of psychophysiological processes to drive human behavior. Many genetic and environmental factors may cause dysregulation of affective states, resulting in disorders that severely disrupt normal cognitive function and diminish the quality of life. Transitions among affective states...
Organic semiconductors have shown great promise for optoelectronic applications, particularly solar photovoltaics. Critical to their success is the ability to understand and manipulate the relationship between molecular structure and bulk properties. Substantial progress on understanding structural influences on electronic properties has been made for the conjugated polymers and small molecules...
We present two novel, computational models of biofilm growth within an experimental flow cell. First, we use asymptotic approximations to develop a reduced model that captures the large-scale dynamics within an entire flow cell. The reduced model's predicted growth and nutrient distribution are close to the values predicted by previous...
In the face of a changing climate caused by anthropomorphic release of carbon dioxide and other greenhouse gases, major governments have committed to the reduction of CO2 and other emissions over time, requiring increased reliance on forms of carbon-free renewable energy. The inherent intermittency of renewable electricity sources creates a...
The rise in children’s media use (Rideout & Robb, 2020) and the prioritization of STEM learning (Fayer et al., 2017) has led to the development of new STEM-related apps, TV shows, and other media for young children. One topic in this area gaining popularity is computational thinking (CT). Researchers refer...
Light is a powerful tool for manipulating and probing magnetic states in solid state systems. In particular, optically-induced spin orientation, the ability to orient spin with polarized light, has been extensively utilized in low-dimensional III-V and II-VI semiconductors to pioneer spintronic research. Even though traditional semiconductors have found a wide...
A proliferation of new media platforms have upended the traditional roles that journalists have played in society, placing their work into content streams that are populated by creators who mimic the surface features of their work but not their methods. As a result, journalists’ practices and news media that they...
We present a biophysical model of GCaMP6f calcium fluorescence in CA1 pyramidal neuron dendrites based upon results from imaging and electrophysiology experiments. This work was completed using experimental results from the laboratory of Professor Daniel Dombeck, Department of Neurobiology. Constraining the model to reproduce different objectives --- from in-vitro and...
In this paper, we study the basic locus in the fiber at $p$ of a certain unitary Shimura variety with a certain parahoric level structure. The basic locus $\widehat{\CM^{ss}}$ is uniformized by a formal scheme $\CN$ which is called Rapoport-Zink space. We show that the irreducible components of the induced...
As of 2020, there are currently 5.8 million people in the United States suffering from Alzheimer’s Disease (AD), a debilitating and progressive neurodegenerative disorder. Of these nearly six million people, two-thirds are women. While it has been suggested that women’s longer lifespan accounts for this disparity, the overall lifetime risk...
We investigated the relationships between trauma, depression, and pelvic pain severity in patients with chronic pelvic pain. Previous research has demonstrated that pelvic pain is associated with trauma history (e.g., physical and sexual abuse). As one potential mechanism of this relationship, trauma may lead to increased susceptibility to pain by...
Down syndrome occurs in approximately 1 in 700 births annually in the United States. It is caused by trisomy of chromosome 21, and is characterized by dysmorphic features and congenital abnormalities. Although children with DS have a decreased risk of developing solid tumors, they have an increased risk of acquiring...
In this dissertation, we aim to develop a theoretical understanding of foundation models and reinforcement learning. We delve into a comprehensive analysis of specific aspects within these domains. The focal points of our study are as follows: • Generative Adversarial Imitation Learning (GAIL) with Neural Networks: GAIL is poised to...
Mitochondrial complex I is the primary entry point for electrons into the mitochondrial electron transport chain that is composed of 45 individual protein subunits that are encoded in both the nuclear and mitochondrial genomes. Mitochondrial complex I sits at an important nexus in the essential bioenergetic, biosynthetic, and signaling functions...
This thesis studies Bayesian-robustness of algorithm design. The main perspective requires for a single fixed algorithm that its performance is an approximation of the optimal performance when its inputs are independent and identical draws (i.i.d.) from every unknown distribution which is an element of a known, large class of distributions....
Parasitic nematode infections are common in both humans and livestock populations around the globe. In humans, these infections cause illness which can be debilitating. In livestock, parasitic nematode infections result in poor animal health and wellbeing as well as decreases in the yield of these animals. The decrease in yield...
Wireless power strategies are critical to system level implementation of bio-integrated devices. To achieve mechanically robust, manufacturable systems, batteries are often integrated as an on-board power source to support sensing, wireless communication and signal conditioning. Unfortunately, most sources of battery power use hazardous and environmentally harmful materials, which frustrate incorporation...
Cancer remains a leading cause of death worldwide, necessitating continued study to explore and unravel its complex etiology. For example, there has been a shift of focus in cancer treatment from surgery and radiotherapy to targeted chemo- and immunotherapies as we gain more knowledge on the hallmarks of cancer (e.g.,...
Rivers and streams play a critical role in connecting major global carbon pools – land, oceans, and atmosphere. The longitudinal flow in rivers and streams allows for the integration and transport of fluvial particulate organic carbon (POC) from various sources and its continual transformation. A continuum-oriented perspective suggests longitudinal variations...
The study of magnetic frustration has attracted considerable interest in the fields of materials science and condensed matter physics. Artificial Spin Ices (ASIs) are the primary systems in which magnetic frustration has been studied. To date, most studies on ASIs have been on fully periodic systems. In this thesis, we...
On-shell formulations of scattering amplitudes for quantum field theories, without utilizating the local descriptions of Lagrangian and Feynman diagrams, have become increasingly useful and important in recent years for both formal and practical reasons. The nonlinear sigma model (NLSM), which describes the interactions between Nambu-Goldstone bosons, is an ideal testing...
Owing to policy action as well as continued cost declines, solar and wind resources are projected to play a central role in many future electricity systems. Since the technological characteristics and cost structures of these resources differ significantly from traditional thermal technologies, many have questioned how market designs will need...
This dissertation addresses problems in the source properties of major earthquakes. It is composed of four largely independent studies. In chapter 2, we explore the possible theoretical origin of the distance-depth correction q(, h) introduced 75 years ago by B. Gutenberg for the computation of the body wave magnitude mb,...
The treatment of AML remains to be a challenge due to the high rates of resistance and relapse experienced by patients after initial therapy. The MAPK-interacting kinases 1 and 2 (MNK1/2) have generated increasing interest as therapeutic targets for AML due to their critical role in malignant hematopoietic transformation via...
The goal of the work reported here was to answer two important questions with regards to LTVV use for patients with ARDS: 1) How do we measure adoption? and 2) What are the drivers of provider adoption? To this end, I have demonstrated the influence of patient height, hypoxemia severity,...
Understanding the complex genome-phenome associations behind human complex traits will be a primary focus for the practice of precision medicine in the future. Identifying the genetic variants that contribute to the inter- and intra- phenotypic variations of individuals, elucidating pleiotropic architecture of common complex traits, and demonstrating how personal biomedical...
Blockchains are an exciting new type of Peer-to-Peer (P2P) distributed systems, which enable parties to transact directly, and maintain the record of said interactions in a distributed manner. A unique feature of blockchains is their ability to maintain a consensus without requiring knowledge on the number of participants, nor their...
In multiatomic systems, high applied pressures reduce interatomic contact distances. At pressures comparable to those inside planets, this relatively simple principle completely changes the guiding principles of chemistry and physics established at near-ambient conditions. High-pressure investigations of precisely how the laws of nature evolve in the gigapascal and megabar regime...