Index Catalog // Arch : Northwestern University Institutional Repository

Start Over

Filtering by: Creator Jonathan Brooks Bell Keyword Glioblastoma Resource type Dissertation Subject Driskill Graduate Training Program in Life Sciences

1 entry found

List Gallery Masonry Slideshow

MNK-eIF4E Signaling and mRNA Translation Regulate Mesenchymal Glioma Stem Cell Maintenance and Promote Therapeutic Resistance in Glioblastoma

Description:

MAPK-interacting kinase (MNK) signaling leads to activation of cap-dependent mRNA translation through phosphorylation of the eukaryotic translation initiation factor 4E (eIF4E). In cancer cells, MNK-eIF4E signaling promotes translation of oncogenic mRNAs. In glioblastoma (GBM), the deadliest malignant brain tumor, MNK-eIF4E signaling is aberrantly activated and represents a promising therapeutic target....

Keyword:

MAPK-interacting kinase, Glioblastoma, and Glioma stem cells

Subject:

Driskill Graduate Training Program in Life Sciences

Creator:

Jonathan Brooks Bell

Owner:

Scholarly Digital Publishing

Date Uploaded:

10/26/2018

Date Modified:

10/26/2018

Date Created:

2017-01-01

Resource Type:

Dissertation

LIBRARIES | ARCH

Limit your search

Type

Resource type

Creator

Keyword

Subject

MNK-eIF4E Signaling and mRNA Translation Regulate Mesenchymal Glioma Stem Cell Maintenance and Promote Therapeutic Resistance in Glioblastoma

Limit your search

Type

Resource type

Creator

Keyword

Subject

Search Constraints

Search Results

MNK-eIF4E Signaling and mRNA Translation Regulate Mesenchymal Glioma Stem Cell Maintenance and Promote Therapeutic Resistance in Glioblastoma