Affect represents a major domain of human consciousness, consisting of a complex group of psychophysiological processes to drive human behavior. Many genetic and environmental factors may cause dysregulation of affective states, resulting in disorders that severely disrupt normal cognitive function and diminish the quality of life. Transitions among affective states...
Memory management and address translation need significant optimizations in order to not behindrances in the near future. Currently, plenty of work has started to address issues within the
current abstraction of the hardware-software codesign of paging. I argue that a new abstraction
is needed in order to properly address this...
Vimentin intermediate filaments (VIFs) provide mechanical integrity to cells and serve as markers of tissue origin and cell differentiation. Several non-mechanical roles for vimentin have recently been reported, including regulation of key pathways that control cell growth, cell signaling, and cell motility. Here, I present the role of vimentin in...
People are exposed to inaccurate claims and ideas every day, from sources intended to inform, entertain, or do both. A large body of research has demonstrated that exposure to inaccurate statements, even when conveying obviously false ideas, can affect people’s subsequent judgments. Contemporary accounts suggest that these effects may be...
We are witnessing an excitement about digital games and related immersive media as these become ever more prevalent in the world. Governments, private companies, and research institutes are investing in these technologies in hopes of transforming education. However, while scholarship on digital game-based learning has been steadily growing over the...
Transfer of information across membranes is fundamental to the function of all organisms and is primarily initiated by transmembrane receptors. This is an allosteric process and involves conformational coupling between ligand-binding domain and signaling domain of a receptor. This allosteric mechanism of activation is unclear for many receptors. Moreover, for...
This dissertation assesses the relationship between inequality and the longevity of urban communities. It does so through an examination of low-status households, a population segment I term Urban Commoners, at the ancient Maya city of Aventura, Belize. Aventura was a socioeconomically diverse urban center that grew to its peak in...
Breakthroughs in large-scale biological data collection have resulted in a wealth of -omics (genomics, metabolomics, etc.) datasets in the literature. However, the development of appropriate computational techniques for their analysis is lacking, yet crucial for fully extracting the rich information contained in these datasets. The work in this dissertation describes...
Shoulder (glenohumeral joint) osteoarthritis causes pain, limits daily activities, and frequently requires joint replacement surgery. In shoulder osteoarthritis, the glenoid bone surface erodes in one of two ways: symmetrically (concentric deformity) or asymmetrically (eccentric deformity). Shoulder replacements in patients with eccentric deformities fail and require additional, revision surgery more often...
Conventional polymer networks are composed of strong, fixed covalent cross-links. The covalent cross-links render polymer networks with outstanding mechanical properties, heat stability, and chemical resistance; however, they also prevent polymer networks from being decross-linked or/and recycled into similar-value products at the end of their life, leading to environmental and economic...