Pseudomonas aeruginosa is an important gram-negative opportunistic pathogen whose large genome allows it to thrive in diverse environments. There is a wide range of phenotypic variation within the species, which can be attributed both to variation in sequences present in most isolates (the core genome) or the presence or absence...
Deep learning is a new area of machine learning research that allows deep neural networks composed of multiple processing layers to learn representations of data with multiple levels of abstraction. Deep learning has helped in achieving the objective of pushing machine learning closer to one of its original goals of...
Polymer nanocomposites have attracted great interest in recent years because of their potential as tailored materials with enhanced properties. Recent experiments have shown that polymer nanocomposites are able to achieve significant improvement in dielectrical, thermal, mechanical and other physical properties compared with their parent polymer systems. More importantly, these outstanding...
Platelets are circulating anucleate discs derived from megakaryocytes, and play major roles in hemostasis, inflammation, thrombosis, and vascular biology. Multi-phase culture systems for inducing in vitro platelet production from mature megakaryocytes have been explored to allow progenitor expansion, megakaryocyte maturation, and promotion of platelet formation and shedding. In this thesis,...
Cells are complex, autonomous machines that integrate many environmental cues to execute a desired response. Though this property makes cells versatile, it presents significant design challenges when, to treat diseases, we must alter cellular responses. To understand changes to the complex regulatory pathways that cause diseases, studies often investigate the...