PilD is an enzyme that processes prepilins that are part of the type II protein secretion apparatus and the type IV piliation machinery. Using a <em>Legionella pneumophila pilDlacZ</em> fusion strain to measure transcription, we observed a 20% increase in beta-galactosidase levels at 30°C vs. 37°C. At 25°C and 17°C vs....
Phylogenetic analysis of HIV is a useful tool in determining factors that may contribute to transmission cluster growth. To better target HIV prevention, it is necessary to understand how research and surveillance data can be combined in a meaningful way.HIV genetic sequences were collected in the RADAR cohort of YMSM...
Recently, much public attention has been focused on racial inequalities in who is subjected to exclusionary school disciplinary policies, and consequently, forced to miss hours of instruction. Over the past two decades, researchers have documented the disparate impacts that zero-tolerance policies have had on students of color, low-income students, and...
Pediatric participants performed a series of trials that involved stepping up onto a raised platform. Body weight load was modulated during this task from -20% to +15% in 5% increments (excluding -5%). Outcome measures include peak hip abduction moments, peak support moments, and individual hip, knee, and ankle percent contributions...
Patients with sickle cell disease (SCD) experience lifelong struggles with both chronic and acute pain, often requiring medical intervention. Pain can be managed with medications, but dosages must balance the goal of pain mitigation against the risks of tolerance, addiction and other adverse effects. Setting appropriate dosages requires knowledge of...
On college campuses, one in five women will experience sexual assault in some capacity over the course of their undergraduate experience. College men in fraternities are three times more likely to commit sexually assaultive acts than non-Greek students. Despite pervasive knowledge that fraternity members are often involved in rape on...
This project is comprised of primary source research on the field of semiconductor microscopy. We were interested in determining a more interdisciplinary application of this technology, as the most frequently cited applications are for defense purposes such as drug screening or infrared imaging. When we researched, we found that these...
Much has already been discovered about the Hedgehog (Hh) signaling pathway and its involvement in patterning and tissue development in embryos, but the specific functions its key components play has not yet been fully elucidated. One potential component is the protein kinase Dop, which is involved in cellular trafficking. Here,...
This project was originally motivated by a lifelong love of the Harry Potter series and a teenage love for fan fiction and other fancreated works. I was motivated to do research when I stumbled upon the lack of inclusivity in many fan communities, which I found to be shocking. In...
The E-Science Working group designed a survey in 2013 to investigate how researchers at Northwestern University manage data and to help determine researchers’ needs or requirements for data storage, preservation and sharing.
The 21 question survey looked at several areas involving data and data management, including the types and size...