Age-related cognitive deficits are observed in both humans and animals. Yet, the molecular mechanisms underlying these deficits are not yet fully elucidated. In aged animals, a decrease in intrinsic excitability of pyramidal neurons from the CA1 sub-region of hippocampus is believed to contribute to age-related cognitive impairments, but the molecular...
Patients with the Primary Progressive Aphasia (PPA) clinical syndrome have diverse forms of neuropathology, one of which is the cellular and molecular abnormalities of Alzheimer’s disease (AD), at post mortem autopsy. Structural anatomical differences might aid in ante mortem differential diagnosis of neuropathology. The studies in this dissertation investigated one...