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Description:: The apolipoprotein E (APOE) E4 isoform is the strongest genetic risk factor for sporadic Alzheimer’s disease (AD). While APOE is predominantly expressed by astrocytes in the central nervous system, neuronal expression of APOE is of increasing interest in age-related cognitive impairment, neurological injury, and neurodegeneration. Here we show that endogenous...
Keyword:: APOE, Alzheimer, Stem Cells, and CRISPR
Subject:: Molecular biology, Medicine, and Neurosciences
Creator:: Wadhwani, Anil R
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/12/2020
Date Created:: 2019-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:14520 and etdadmin_upload_639542

Description:: Glioblastoma multiforme (GBM) is the most prevalent primary central nervous system tumor, characterized by resistance to therapeutic intervention, inevitable recurrence, and ultimately patient death. The dismal prognosis is due in part to underlying molecular factors that promote an intratumoral cellular state heterogeneity and protect tumor cells from cell death pathways....
Keyword:: Ferroptosis, Glioblastoma, Cancer, Stemness, Metabolism, and IDH1
Subject:: Molecular biology, Medicine, and Neurosciences
Creator:: Murnan, Kevin Michael
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 06/22/2022
Date Created:: 2022-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:15885 and etdadmin_upload_865864

Description:: Inter-organelle contact sites have become increasingly appreciated as important regulators of cellular homeostasis, and disruption of inter-organelle contact site dynamics and function has been observed in various pathologies. Recently, inter-organelle contact sites between mitochondria and lysosomes were discovered, offering a new mechanism by which these two organelles may directly interact,...
Keyword:: Imaging, Contact Sites, Lysosome, Mitochondria, Neurological Disease, and Calcium
Subject:: Biology, Medicine, and Neurosciences
Creator:: Peng, Wesley J
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 10/07/2021
Date Created:: 2021-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:15610 and etdadmin_upload_827420

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