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- Description:
- Frontotemporal Dementia (FTD) and Amyotrophic Lateral Sclerosis (ALS) are two devastating neurodegenerative diseases that affect 100,000s of people globally. They have a severe adverse impact on society, yet there are currently no early diagnostic tools or disease-modifying therapies available. Despite their clinical heterogeneity, evidence points to these diseases being on...
- Keyword:
- microRNA, Compositional Data Analysis, TDP-43 Proteinopathy, FUS Proteinopathy, RNA-Seq, and Mitochondria
- Subject:
- Molecular biology, Bioinformatics, and Neurosciences
- Creator:
- McGee, Warren A
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14675 and etdadmin_upload_663037
-
- Description:
- Biological tubes are essential for animal survival, and their functions are highly dependent on tube shape. Analyzing the contributions of cell shape and organization to the morphogenesis of small tubes has been hampered by the limitations of existing programs in quantifying cell geometry on highly curved tubular surfaces and calculating...
- Subject:
- Biology
- Creator:
- Yang, Ran
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_674761 and http://dissertations.umi.com/northwestern:14738
-
- Description:
- The presence of unwanted biofilms on surfaces is a great concern for industrial, naval, and healthcare fields, and many other settings. To better inhibit, remove, or harness the properties of biofilms, an explanation of how specific structural or chemical features of biofilm matrix components leads to enhanced adhesion and persistence...
- Keyword:
- adsorption, protein mechanics, curli, biofilm, Molecular Dynamics, and CsgA
- Subject:
- Mechanical engineering
- Creator:
- DeBenedictis, Elizabeth
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_686008 and http://dissertations.umi.com/northwestern:14823
-
- Description:
- Flowing granular mixtures with species differing in some property, such as size, shape or density of the grains, tend to segregate (de-mix) during flow. Since flowing granular materials are common in industry, and since segregation is often unwanted and costly, understanding and mitigating segregation is an important concern in industrial...
- Subject:
- Mechanical engineering
- Creator:
- Fry, Alexander Michael
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14808 and etdadmin_upload_685275
-
- Description:
- This dissertation is a history of religious conservatism between 1880 and the onset of the Great Depression in 1929. Its main argument is that conservative religion in America, rather than being defined by fundamentalism, theological disputes, or cultural antipathy towards pluralism, was an outgrowth of a profound faith in capitalism...
- Keyword:
- Culture Wars, Conservatism, Fundamentalism, Capitalism, and Billy Sunday
- Subject:
- History and Religious history
- Creator:
- Noddings, Timothy Robert
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_657277 and http://dissertations.umi.com/northwestern:14570
-
- Description:
- The analytical paradigm in philosophy has as a pillar an analysis of the sentence as a basic entity. New sentences may be built from old sentences recursively through the application of logical constants, recently including intensional operators. Models are built on how these logical constants interact with each other, and...
- Keyword:
- Conditionals, Modality, Abstract Algebra, Lambda Calculus, Generative Grammar, and Intension
- Subject:
- Logic, Linguistics, and Computer science
- Creator:
- Cook, Ezra Joseph
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_618271 and http://dissertations.umi.com/northwestern:14415
-
- Description:
- Soft materials such as colloids and polymers often exhibit a variety of mesoscopic structures that are governed merely by weak physical interactions. Due to these intermediate structures, they can be easily taken out of thermal equilibrium by introducing external stimuli such as a shear flow and electromagnetic fields. This thesis...
- Keyword:
- Phase transition, Nonequilibrium dynamics, Coarse-grained simulations, Self-assembly, Soft matter, and Machine Learning
- Subject:
- Materials Science, Computational physics, and Statistical physics
- Creator:
- Han, Ming
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14411 and etdadmin_upload_618073
-
- Description:
- While Li-ion batteries are currently the preferred energy storage technology, multivalent alternatives such as Mg should be considered. Magnesium metal has a high volumetric capacity and has been shown to cycle with no dendrite formation. However, the highly charged Mg2+ ion cannot easily diffuse into the oxide cathodes favored in...
- Keyword:
- Solid State Chemistry, Multivalent Batteries, Magnesium Cathodes, and Hydrothermal Synthesis
- Subject:
- Inorganic chemistry and Chemistry
- Creator:
- Wustrow, Allison
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_662066 and http://dissertations.umi.com/northwestern:14625
-
- Description:
- This project traces the efforts by Scottish Protestants to achieve complete religious uniformity in the decades following the Reformation. Discontented with outward conformity, the via media that long characterized our understanding of religious reform in England, Scotland’s ministers sought to work genuine conversions among those who resisted the new order....
- Keyword:
- Kirk, Scotland, Catholics, Catholicism, Reformation, and Presbyterians
- Subject:
- History and European history
- Creator:
- Burns, Ryan Christopher
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_661778 and http://dissertations.umi.com/northwestern:14612
-
- Description:
- One of the grand challenges in science is development of soft materials that mimic living organisms to optimize the way we use energy, translate or morph reversibly or sense their envi- ronment and respond in a useful fashion. Using the insights from studying biological structures, we hope to design soft...
- Subject:
- Materials Science, Biochemistry, and Computational chemistry
- Creator:
- Iscen, Aysenur
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14770 and etdadmin_upload_679718