Megakaryocytic cells (Mks) are derived from hematopoietic stem cells (HSCs) and give rise to platelets. Ex vivo culture of HSCs under conditions that promote Mk differentiation has been proposed as a method for producing Mks and platelets for cell therapies. Mk maturation involves the development of polyploid cells via endomitosis,...
Modeling and simulation at different scales were used to study mass transport, residence times and selective oxidation in nanostructured membranes. First, analytical equations of the possible mass transport mechanisms inside the pores were used to determine that diffusion dominates over convection under the conditions of interest for selective oxidation: 700...