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Filtering by: Keyword Cerebral organoids Keyword Intellectual disability Subject Molecular biology Subject Neurosciences

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1. Determining Disease Mechanisms of PACS1 Syndrome ASD Using iPSC-Derived Models

Description:: Autism spectrum disorder (ASD) and intellectual disability (ID) are two of the most highly prevalent neurodevelopmental disorders (NDDs), each affecting roughly 2% of the population. Despite the need for therapies, few exist due to a myriad of challenges, such as the complex underlying genetic etiology and historic inaccessibility of neural...
Keyword:: PACS1 syndrome, Induced pluripotent stem cells, Single-cell RNA sequencing, Intellectual disability, Cerebral organoids, and Autism spectrum disorder
Subject:: Molecular biology and Neurosciences
Creator:: Rylaarsdam, Lauren Elizabeth
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 05/31/2023
Date Created:: 2023-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_984633 and http://dissertations.umi.com/northwestern:16538