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- Description:
- Regulatory T (Treg) cells are required to control immune responses and maintain homeostasis, but are a significant barrier to antitumor immunity. Conversely, Treg instability, characterized by loss of the master transcription factor Foxp3 and acquisition of proinflammatory properties, can promote autoimmunity and/or facilitate more effective tumor immunity. A comprehensive understanding...
- Keyword:
- Tumor, Treg, Ubiquitin, Foxp3, Usp21, and Usp22
- Subject:
- Biology, Cellular biology, and Immunology
- Creator:
- Montauti, Elena
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/02/2022
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_846345 and http://dissertations.umi.com/northwestern:15780
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- Description:
- Existing nonlinear optimization methods have proven reliable over the past few decades for a wide range of applications but have critically relied on accurate function and gradient evaluations. Modern nonlinear optimization problems arising from machine learning and scientific computing applications are increasingly complex and large scale, which make accurate evaluations...
- Keyword:
- Finite differences, Nonlinear optimization, Stochastic optimization, Noisy optimization, Quasi-Newton methods, and Derivative-free optimization
- Subject:
- Applied mathematics, Operations research, and Computer science
- Creator:
- Shi, Hao-Jun Michael
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/02/2022
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_848013 and http://dissertations.umi.com/northwestern:15785
-
- Description:
- This dissertation reorients political theory to the concepts of use and utility for a more critical and emancipatory perspective on contemporary communal life. The reorientation entails a recovery of Aristotle’s and Marx’s overlapping approaches to use, whose contemporary reception indexes the surprising alignment of critical political theory with economics. That...
- Keyword:
- Democracy, Critical Theory, Aristotle, Marx, Indeterminacy, and Utility
- Subject:
- Philosophy, Classical studies, and Political science
- Creator:
- Bradshaw, Tristan
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/02/2022
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15868 and etdadmin_upload_863374
-
- Description:
- Semiconductor nanocrystals possess unique photophysical properties that make them desirable for many optoelectronic applications such as photovoltaics, LEDs, and quantum computing. When the size of a semiconductor is reduced to below the excitonic Bohr radius of the material, its carriers becomes quantum confined resulting in drastic changes to optical, electronic,...
- Keyword:
- Nanocrystals, Spin, Semiconductors, Spectroscopy, Thermal properties, and Carrier Dynamics
- Subject:
- Physical chemistry, Chemistry, and Materials Science
- Creator:
- Harvey, Samantha
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/02/2022
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_857543 and http://dissertations.umi.com/northwestern:15830
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- Description:
- Nanomaterials offer unique properties not seen in their macroscopic kin. They can be used in printed electronics, as catalysts, and so much more. However, their diminutive size complicates materials processing techniques. They can easily aggregate become no longer useful. A solution to this is to use a polymeric surfactant such...
- Keyword:
- Liquid Metal, Nitrocellulose, and Graphene
- Subject:
- Nanoscience
- Creator:
- Wallace, Shay Goff
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/02/2022
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_850636 and http://dissertations.umi.com/northwestern:15791
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- Description:
- The field of robot design mostly focuses on careful construction of complex control and planning algorithms (e.g., tuning neural network weights) which bear sole responsibility for improving task performance, while the robot’s body is often assumed to be part of the environment. In nature, however, biological organisms co-evolve both their...
- Keyword:
- Co-Design, Task Embodiment, Robots, and Emergence
- Subject:
- Robotics and Design
- Creator:
- Pervan, Ana
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/02/2022
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15878 and etdadmin_upload_863964
-
- Description:
- One of the most pressing open questions in star formation is the role of magnetic fields relative to turbulence and gravity, and how these three processes set the stellar initial mass function and star formation efficiency. In this work, we present the state of BLAST-TNG (the Balloon-borne Large Aperture Submillimeter...
- Keyword:
- balloon-borne, star formation, telescope, magnetic fields, and polarimetry
- Subject:
- Astronomy
- Creator:
- Williams, Paul Andrew
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/02/2022
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_858493 and http://dissertations.umi.com/northwestern:15838
-
- Description:
- Critical pedagogies offer a particular orientation towards education that understands the process of learning as inherently political. These frameworks demand explicit political attention by teachers to support student development of practices needed to create a liberatory world. Recent work evidences the positive impact critical pedagogies have on students academically, civically,...
- Keyword:
- history education, critical pedagogy, critical social analysis, relationality, and disciplinary education
- Subject:
- History, Education, and Ethnic studies
- Creator:
- Jackson, Ava
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/02/2022
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_854486 and http://dissertations.umi.com/northwestern:15811
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- Description:
- T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive disease, affecting children and adults. Chemotherapy regimens show high response rates but have debilitating effects and carry risk of relapse. Until now, no targeted therapy has been approved. In addition, 40% of patients will relapse and their treatment options are limited because...
- Keyword:
- USP11, LCK, USP7, glucocorticoid, leukemia, and ubiquitination
- Subject:
- Molecular biology, Oncology, and Biochemistry
- Creator:
- Gutierrez Diaz, Blanca Teresa
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/02/2022
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_862777 and http://dissertations.umi.com/northwestern:15858
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- Description:
- Language models are the foundation of many natural language tasks such as machine translation, speech recognition, and dialogue systems. Modeling the probability distributions of text accurately helps capture the structures of language and extract valuable information contained in various corpora. In recent years, many advanced models have achieved state-of-the-art performance...
- Subject:
- Artificial intelligence, Statistics, and Computer science
- Creator:
- Ju, Wei
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/02/2022
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_863369 and http://dissertations.umi.com/northwestern:15867