With connected vehicle generated (CVG) information, traffic stream parameters become straightforwardly quantifiable, enabling traffic state characterization and examination over a variety of operational conditions. Since the observation is independent of any spatial restrictions and unaffected by queue buildup and discharge, CVG data offer more comprehensive, more reliable inputs to the...
This dissertation studies three aspects of health insurance market regulation and design. Chapter 1 (which is joint work with Steve Cicala and Ethan Leiber) studies a regulatory mechanism used to constrain insurer market power. The mechanism targets health insurers' Medical Loss Ratio, which is the share of premiums spent on...
Using social network analysis and legal, regulatory, and policy-based case studies, this dissertation explores the ways information and communication technologies (ICT) are regulated internationally. First, it details the composition of the interorganizational, cross sector network, describing the member and governance bodies active in ICT standard setting organizations (SSOs) and the...
This dissertation asks how researchers can create more equitable algorithmic systems. Ultimately, this thesis explores methods and implications of representing subjects of analysis in the design and evaluation of algorithmic systems. I also unpack how algorithmic tools measure and quantify human behavior, giving heed to the potential impacts of these...
Compromised protein homeostasis underlies accumulation of plaques and tangles in Alzheimer’s disease (AD); however, little is known about the early mechanisms that contribute to this process. To objectively assess protein turnover at early stages of amyloid beta (Aβ) proteotoxicity, we used dynamic metabolic labeling with stable isotopes followed by proteomic...
This dissertation addresses questions in the fields of household finance and corporate finance. In Chapter 1, I use a quasi-experiment in Norway to examine how households respond to capital taxation. The introduction of a new wealth assessment methodology in 2010 led to geographic discontinuities in household exposure to wealth taxes,...
In the short amount of time that genetic manipulation has been possible through CRISPR technology, myriad applications have been developed. Results from one of the most promising applications of this technology, pooled screens, have shown that single guide RNAs (sgRNAs), RNA sequences used to target specific regions of the genome,...
Background: Cancer-related cognitive impairment (CRCI) is among the most frequently reported adverse events during and following cancer treatment. Between 17% to 75% of chemotherapy-treated cancer patients evidence long-term cognitive deficits as many as 20 years after treatment. The variability in prevalence and the mechanisms of persistent CRCI are not well...
This dissertation is a contribution to the depth and breadth of prison media history. I position prison media of the 1970s as key antecedents to the prison reality television of the 2000s and today. The purpose of this arrangement is to bring attention to an era of prison media that...
Organic chromophores show great promise for energy and optoelectronic devices, due to their synthetic tunability and low production costs. In order to achieve this potential, their fundamental photophysical processes must be better understood. It has long been documented that chromophore packing at the molecular level has dramatic effect on electronic...