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-
- Description:
- Glioblastoma (GBM) is the most common aggressive primary malignant brain tumorin adults with a median age of onset of 65 years of age. Although advanced age is often associated with worse GBM patient survival, the predominant source(s) of maladaptive aging effects remains to be established. Here we studied intra-tumoral and...
- Keyword:
- Senescence, p16INK4a, Glioblastoma, Aging, and Immunotherapy
- Subject:
- Biology and Neurosciences
- Creator:
- Bell, April Charlotte
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16795 and etdadmin_upload_1016132
-
- Description:
- Kaposi’ sarcoma-associated herpesvirus (KSHV) causes primary effusion lymphoma (PEL). PEL cell lines require expression of the cellular FLICE inhibitory protein (cFLIP) for survival, although KSHV encodes a viral homolog of this protein (vFLIP). Cellular and viral FLIP proteins have several functions, including, most importantly, the inhibition of pro-apoptotic caspase 8...
- Keyword:
- cFLIP, DR4, TRAIL-R1, cell death, HHV-8, and primary effusion lymphoma
- Subject:
- Microbiology and Biology
- Creator:
- Kuehnle, Neil Joseph
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16705 and etdadmin_upload_1010776
-
- Description:
- Cancer is a complex and heterogeneous disease characterized by aberrant gene regulation. Gene regulation is fundamentally orchestrated by the 3D genome organization which involves chromatin looping, compartmentalization, and the formation of topologically associating domains (TADs). Structural variations (SVs), such as genomic rearrangements, deletions, inversions, and duplications, are commonly observed in...
- Subject:
- Bioinformatics and Biology
- Creator:
- Wang, Juan
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16734 and etdadmin_upload_1013045
-
- Description:
- Transcription plays a pivotal role in the transfer of genetic information within living organisms. It serves as the initial step in gene expression, allowing cells to convert the instructions encoded in their DNA into functional molecules. Eukaryotic transcription initiation is a complex and dynamic process that requires joint efforts from...
- Keyword:
- transcription, FRET, mediator, structural, cryo-EM, and polymerase
- Subject:
- Biology
- Creator:
- Talyzina, Anna
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16677 and etdadmin_upload_1005509
-
- Description:
- This dissertation focuses on quantifying protein folding stability determinants and presenting initial experiments that can guide the development of a novel assay that identifies cell-penetrating miniproteins. First, despite over a century of scholarship on protein folding stability, applying this knowledge to design proteins computationally remains limited. Usually, protein designers generate...
- Keyword:
- protein design, cell-penetrating protein, protein folding stability, and synthetic biology
- Subject:
- Biology, Cellular biology, and Biophysics
- Creator:
- Kim, Tae-Eun
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_1008136 and http://dissertations.umi.com/northwestern:16683
-
- Description:
- This dissertation focuses on quantifying protein folding stability determinants and presenting initial experiments that can guide the development of a novel assay that identifies cell-penetrating miniproteins. First, despite over a century of scholarship on protein folding stability, applying this knowledge to design proteins computationally remains limited. Usually, protein designers generate...
- Keyword:
- protein design, cell-penetrating protein, synthetic biology, and protein folding stability
- Subject:
- Biology, Cellular biology, and Biophysics
- Creator:
- Kim, Tae-Eun
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16695 and etdadmin_upload_1009800
-
- Description:
- The negative early and late health consequences from exposure to artificial sources of radiation are particularly apparent in victims of radiological emergencies who were diagnosed with cancer, radiation pneumonitis, among other conditions. The renaissance of nuclear energy, increased use of ionizing radiation in the medical field, and nuclear threats from...
- Keyword:
- Radiobiology, Ionizing Radiation, Radionuclides, and Radiation Biology
- Subject:
- Epidemiology, Biology, and Health sciences
- Creator:
- Copeland-Hardin, Letonia
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16738 and etdadmin_upload_1013192
-
- Description:
- Stimulation of the cGAS-STING (cycle GMP-AMP synthase-Stimulator of Interferon Genes) pathway increases T cell activation and tracking into the tumor and reverses the immunosuppressive phenotype of myeloid cells. Direct targeting of the STING receptor using synthetic cyclic dinucleotide (CDN) ligands represents an attractive immunotherapeutic strategy for the treatment of lymphocyte-depleted...
- Keyword:
- GBM, Spherical nucleic acids, cGAS, Immunotherapy, and STING
- Subject:
- Biology, Biochemistry, and Immunology
- Creator:
- Mahajan, Akanksha Sanjay
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 05/31/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_983546 and http://dissertations.umi.com/northwestern:16516
-
- Description:
- Pediatric high-grade gliomas (pHGGs) are aggressive pediatric CNS tumors and an important subset are characterized by mutations in H3F3A, the gene that encodes Histone H3.3 (H3.3). Substitution of Glycine at position 34 of H3.3 with either Arginine or Valine (H3.3G34R/V), was recently described and characterized in a large cohort...
- Keyword:
- genetics, G34R, cancer, ATRX, glioma, and AVB500
- Subject:
- Molecular biology, Biology, and Biochemistry
- Creator:
- Abdallah, Aalaa Sanad
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 05/31/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16475 and etdadmin_upload_978815
-
- Description:
- Involuntary motor activities such as spasms arise from hyperreflexia in about 70% of individuals with spinal cord injuries (SCI). Despite this prevalence and the negative impact on health and safety, it is unclear what determines the severity of the spasms that develop. This study investigated the impact of injury severity...
- Keyword:
- Movement Disorder, Spinal Cord Injury, and Serotonin
- Subject:
- Physiology, Biology, and Neurosciences
- Creator:
- Shelton, Owen Adio
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 05/31/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16444 and etdadmin_upload_970159
-
- Description:
- The reprogramming of somatic cells to a spontaneously contracting cardiomyocyte-like state using defined transcription factors has proven successful in mouse fibroblasts. However, this process has been less successful in human cells, thus limiting the potential clinical applicability of this technology in regenerative medicine. We hypothesized that this issue is due...
- Keyword:
- calcium cycling, spontaneous contraction, high-throughput, cardiomyocyte, direct reprogramming, and fibroblast
- Subject:
- Biology, Cellular biology, and Developmental biology
- Creator:
- Romero Tejeda, Marisol
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 05/31/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_970274 and http://dissertations.umi.com/northwestern:16446
-
- Description:
- Tumor-initiating cells with reprogramming plasticity are thought to be essential for cancer development and metastatic regeneration in many cancers; however, the molecular mechanisms are not fully understood. We have previously identified that CD44, a breast tumor-initiating cell marker, drives mammosphere self-renewal and multicellular aggregation of circulating tumor cell (CTC) clusters,...
- Keyword:
- exosomes, CD44, cancer stem cells, extracellular vesicles, CD81, and breast cancer
- Subject:
- Molecular biology, Biology, and Cellular biology
- Creator:
- Ramos, Erika Kathryn
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/16/2023
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16152 and etdadmin_upload_916551
-
- Description:
- One of the fundamental questions in developmental biology is how a single cell gives rise to a complex organism. More specifically, how a totipotent egg divides into cells that become increasingly restricted in their potential. Development is a process of increasingly restricted cellular potential, and here I home in on...
- Keyword:
- Xenopus, Pluripotency, Neural Default Model, BMP, Smads, and Activin
- Subject:
- Biology and Developmental biology
- Creator:
- Johnson, Kristin Lorette
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/16/2023
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16347 and etdadmin_upload_945075
-
- Description:
- ABSTRACTFor several decades, dams have played an essential role in human development. In many low-and middle-income countries (LMICs), the construction of dams remains an integral part of industrialization and modernization. However, dam construction and associated infrastructure have significantly contributed to socioecological destruction and population displacement. For example, the construction of...
- Keyword:
- Development, Dams, Thwake Multipurpose Dam, Infrastructure, Biosocial, and Displacement
- Subject:
- Physical anthropology, Biology, and Cultural anthropology
- Creator:
- Owuor, Patrick Mbullo
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 09/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_919619 and http://dissertations.umi.com/northwestern:16170
-
- Description:
- A central theme in biological anthropology is investigating how the human body responds to interactions with the surrounding environment. The microbiome—the collection of microorganisms (and their genes) that live in and on the human body— represents one such pathway that mediates the environment’s influence on human biology, physiology, and health....
- Keyword:
- Alloparents, Skin microbiome, Early life, Social environment, and Infant microbiome
- Subject:
- Microbiology, Ecology, and Biology
- Creator:
- Manus, Melissa Barbara
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 09/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16260 and etdadmin_upload_928946
-
- Description:
- Nuclear receptors (NRs) are an important family of transcription factors that often regulate genes in response to ligands and by way of direct interactions with coactivator proteins. Many NR-coactivator pairs have been identified that cooperate to regulate transcription but fully understanding how NRs recruit specific coactivators involves learning which of...
- Keyword:
- Transcriptional Regulation, NMR, and Nuclear Receptors
- Subject:
- Biology, Biochemistry, and Biophysics
- Creator:
- Daffern, Nicolas
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 09/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16121 and etdadmin_upload_910580
-
- Description:
- Meiosis is a specialized form of cell division that occurs to generate sperm and eggs with unique sets of paternal or maternal DNA; this process shuffles genetic information to promote the amazing variation that we observe in living organisms. In order to carry out two rounds of DNA separation with...
- Keyword:
- Microtubules, Oocytes, Spindle, Acentrosomal, and Meiosis
- Subject:
- Biology
- Creator:
- Cavin-Meza, Gabriel Joseph
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 09/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16253 and etdadmin_upload_928728
-
- Description:
- Pattern formation of biological structures involves the arrangement of different types of cells in an ordered spatial configuration. Patterning is thought to involve the spatial organization of molecular pre-patterns that precede and drive subsequent cell differentiation and coinciding morphogenesis. These molecular prepatterns are often, although not exclusively, organized through Turing...
- Keyword:
- emergence, compound eye, self organization, Drosophila, morphogenesis, and pattern formation
- Subject:
- Biology, Biophysics, and Developmental biology
- Creator:
- Gallagher, Kevin
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 09/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16245 and etdadmin_upload_928342
-
- Description:
- The worldwide community of patients affected by Basal Cell Carcinoma of the skin (BCC) is larger than that of any other cancer. While BCC is rarely lethal, currently available treatment strategies often leave patients with disfiguring scars on their faces, heads, and necks. Moreover, the high recurrence rates of BCC...
- Keyword:
- zinc finger transcription factors, 3D skin cancer model, Basal Cell Carcinoma, Gli transcription factors, cobalt-Schiff base, and graphene oxide
- Subject:
- Inorganic chemistry, Biology, and Biochemistry
- Creator:
- Dukes, Meghan Ward
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 09/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_923011 and http://dissertations.umi.com/northwestern:16188
-
- Description:
- The NLRP3 inflammasome is a multi-protein complex that drives sterile and pathogen-dependent inflammation. Activation of the NLRP3 inflammasome occurs in two steps: priming and activation. Priming occurs in response to an inflammatory stimulus, such as LPS. LPS-primed macrophages are subsequently activated by a second stimuli, most of which require K+...
- Keyword:
- macrophage, mitochondria, immunometabolism, inflammasome, and metabolism
- Subject:
- Biology
- Creator:
- Billingham, Leah Katherine
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15953 and etdadmin_upload_882213
-
- Description:
- In the United States, allergic disease affects approximately 60 million people and impacts more people every year. While prevalence of allergic disease has steadily increased, there has concurrently been an increase in rates of metabolic syndrome—characterized by increased abdominal girth, decreased sensitivity to insulin, and higher levels of circulating blood...
- Keyword:
- lung, hyperglycemia, immunometabolism, homeostasis, allergy, and metabolism
- Subject:
- Biology, Immunology, and Medicine
- Creator:
- Queener, Ashley
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15602 and etdadmin_upload_824073
-
- Description:
- A prominent cause of premature ovarian insufficiency (POI) is gonadotoxic cancer therapies, which deplete the ovarian reserve of follicles, oocytes, and hormone-producing cells. Current fertility preservation methods include the removal and cryopreservation of ovarian tissue prior to gonadotoxic treatment. This cryopreserved tissue can be transplanted back and has been found...
- Subject:
- Biology
- Creator:
- Henning, Nathaniel
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16071 and etdadmin_upload_902584
-
- Description:
- Skeletal muscle is a highly sexually dimorphic tissue, with males and females exhibiting differences in muscle size, gene transcription, and metabolism. This thesis describes two models wherein males and females responded to an intervention with the same physiological adaptation but through two distinct mechanisms. In the first model, mice of...
- Keyword:
- skeletal muscle, sexual dimorphism, and glucocorticoid
- Subject:
- Biology
- Creator:
- Salamone, Isabella M
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_900688 and http://dissertations.umi.com/northwestern:16035
-
- Description:
- Macrophages are innate immune cells that are traditionally thought to be specialists in phagocytosis. More recent evidence suggest that macrophages reside in nearly every organ and readily adapt to local microenvironmental signals, leading to highly plastic phenotypes across and within tissues. Therefore, rather than treating it as a homogenous cell...
- Keyword:
- macrophage, bioinformatics, and NGS
- Subject:
- Bioinformatics and Biology
- Creator:
- Chen, Shang-Yang
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16027 and etdadmin_upload_900059
-
- Description:
- Eukaryotic genomes are organized into chromatin, which acts to regulate access to the organism’s genetic material. A large and diverse class of proteins, known as chromatin modifiers and remodelers, are responsible for regulating the composition and structure of chromatin by monitoring nucleosomes. Chromatin remodelers are involved in multiple cellular processes,...
- Subject:
- Biology, Biochemistry, and Biophysics
- Creator:
- Reyes, Alexis Amaris
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15930 and etdadmin_upload_879245
-
- Description:
- Androgen receptor pathway inhibitors are the mainstay treatment for advanced prostate cancer, but resistance is common. Here, we used a CRISPR activation screen to identify genes that promote enzalutamide resistance in the metastatic castration-sensitive prostate cancer cell line LNCaP. We found that activation of the TGF-β target gene, PRRX2, promoted...
- Subject:
- Biology
- Creator:
- Rodriguez, Yara
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16015 and etdadmin_upload_898469
-
- Description:
- The eukaryotic genome is packaged into chromatin. The nucleosome, the basic unit of chromatin, is composed of DNA coiled around a histone octamer. Histones are among the longest-lived protein species in mammalian cells, due to their thermodynamic stability and their associations with DNA and histone chaperones. Histone metabolism plays an...
- Keyword:
- UBR7, NASP, histone, H3, chaperone, and chromatin
- Subject:
- Biology, Biochemistry, and Genetics
- Creator:
- Ferguson, Ann
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/02/2022
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15808 and etdadmin_upload_853746
-
- Description:
- To combat the rise of antibiotic-resistant pathogens in clinical settings, it is necessary to understand which environments and conditions select for antibiotic resistance. Analysis of environments hypothesized to select for antibiotic resistance has been revolutionized by metagenomic sequencing. The metagenomic pool of DNA sequences can be probed in silico using...
- Subject:
- Microbiology, Bioinformatics, and Biology
- Creator:
- McFarland, Alexander George
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/02/2022
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_862596 and http://dissertations.umi.com/northwestern:15857
-
- Description:
- Ovulation is the process by which an ovulatory follicle releases a mature egg and is essential for fertility and maintaining female reproductive cycle. Understanding the mechanisms of ovulation have implications for the development of non-hormonal contraceptives and treatments of anovulatory diseases. We developed a 3D alginate encapsulated in vitro follicle...
- Keyword:
- soft clustering analysis, single-follicle RNA-seq, follicle culture, ovulation, and non-hormonal contraceptives
- Subject:
- Biology
- Creator:
- Zhang, Jiyang
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/02/2022
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15863 and etdadmin_upload_863229
-
- Description:
- Regulatory T (Treg) cells are required to control immune responses and maintain homeostasis, but are a significant barrier to antitumor immunity. Conversely, Treg instability, characterized by loss of the master transcription factor Foxp3 and acquisition of proinflammatory properties, can promote autoimmunity and/or facilitate more effective tumor immunity. A comprehensive understanding...
- Keyword:
- Tumor, Treg, Ubiquitin, Foxp3, Usp21, and Usp22
- Subject:
- Biology, Cellular biology, and Immunology
- Creator:
- Montauti, Elena
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/02/2022
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_846345 and http://dissertations.umi.com/northwestern:15780
-
- Description:
- The treatment of AML remains to be a challenge due to the high rates of resistance and relapse experienced by patients after initial therapy. The MAPK-interacting kinases 1 and 2 (MNK1/2) have generated increasing interest as therapeutic targets for AML due to their critical role in malignant hematopoietic transformation via...
- Subject:
- Molecular biology, Biology, and Biochemistry
- Creator:
- Suarez Palacios, Milagros Melanie
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 10/07/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_845430 and http://dissertations.umi.com/northwestern:15772
-
- Description:
- Natural Killer (NK) cell dysfunction is associated with poorer clinical outcome in cancer patients. What regulates NK cell dysfunction in tumor microenvironment is not well understood. NKG2D/NKG2DL pathway is very well recognized as an effective immune axis in tumor immunosurveillance. Abundant evidence from experimental preclinical animal models as well as...
- Subject:
- Biology, Cellular biology, and Immunology
- Creator:
- Dhar, Payal
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 10/07/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15682 and etdadmin_upload_839121
-
- Description:
- Processing of sensory information in the brain is a pervasive and fundamental phenomenon across animal species and is involved in both "hard-wired" innate responses as well as learned and adaptive behaviors. Here, I show that the avoidance of hot temperature, a simple innate behavior, contains unexpected plasticity and complex processing...
- Keyword:
- systems neuroscience, sensory navigation, modeling, drosophila, thermosensation, and neural circuits
- Subject:
- Applied mathematics, Biology, and Neurosciences
- Creator:
- Levy, Joshua
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 10/07/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_836701 and http://dissertations.umi.com/northwestern:15663
-
- Description:
- Inter-organelle contact sites have become increasingly appreciated as important regulators of cellular homeostasis, and disruption of inter-organelle contact site dynamics and function has been observed in various pathologies. Recently, inter-organelle contact sites between mitochondria and lysosomes were discovered, offering a new mechanism by which these two organelles may directly interact,...
- Keyword:
- Imaging, Contact Sites, Lysosome, Mitochondria, Neurological Disease, and Calcium
- Subject:
- Biology, Medicine, and Neurosciences
- Creator:
- Peng, Wesley J
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 10/07/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15610 and etdadmin_upload_827420
-
- Description:
- This thesis proposes a robust multi-pronged approach to study the effect of nanoparticles on cells. In the first place, this work is focused on investigation of the protein corona that accumulates on the surface of nanoparticles internalized by the cells and their poly-pathway effects on protein availability and messenger RNA...
- Keyword:
- PARP, Nanoparticles, BIRC5, XFM, and SR-FTIR
- Subject:
- Nanotechnology, Biology, and Biochemistry
- Creator:
- Lastra, Ruben Omar
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 10/07/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_837951 and http://dissertations.umi.com/northwestern:15671
-
- Description:
- The last decade has witnessed a rapid transformation in our understanding of the structure of chromatin, the nuclear complex of DNA and its structural proteins. While, barring mutations, the DNA sequence in each cell of the human body is the same, it is the structure of the chromatin complex that...
- Keyword:
- crowding, nucleus, and dynamics
- Subject:
- Biology, Biophysics, and Biomedical engineering
- Creator:
- Shim, Anne Rosati
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/28/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15565 and etdadmin_upload_818662
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- Description:
- Meiosis is a highly regulated process necessary for proper chromosome division. Zincfluxes regulate mammalian meiosis; between prophase I and metaphase II, total intracellular zinc increases by 50%, while 20% of zinc is released in “zinc sparks” following fertilization. Although zinc fluxes had been shown to be conserved in mammals, it...
- Keyword:
- Xenopus, Sample Fixation, Zinc, Manganese, Fertilization, and EMI2
- Subject:
- Inorganic chemistry, Biology, and Biochemistry
- Creator:
- Seeler, John Frederick
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/28/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_819316 and http://dissertations.umi.com/northwestern:15573
-
- Description:
- Gold nanoparticles (AuNPs) display unique characteristics compared to their macro-counterparts that are dependent on shape, size, and attached surface molecules. Methods have been developed to precisely control both size and shape of AuNPs for specific applications. The biocompatibility, plasmonic properties, and ease of functionalization with thiolated molecules, make gold nanoparticles...
- Keyword:
- gold nanopaticles, therapeutics, DNA, cancer vaccine, and plasmonics
- Subject:
- Nanotechnology, Chemistry, and Biology
- Creator:
- Coughlin, Emma
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/28/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15532 and etdadmin_upload_815702
-
- Description:
- One of the fundamental observations in oncology is that the rate of cancer malignancy increases with age, which applies to most human malignancies including breast cancer. Therefore, it is crucial to elucidate the mechanistic connection between aging and carcinogenesis. The NAD+-dependent sirtuin family, specifically SIRT3, the primary mitochondrial deacetylase, which...
- Keyword:
- MnSOD, mitochondria, Sirtuin, cancer, ACSS1, and metabolism
- Subject:
- Biology
- Creator:
- Gao, Yucheng
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/28/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15526 and etdadmin_upload_815100
-
- Description:
- Bumble bees are ecologically and economically important pollinators but have experienced rapid declines in recent decades. Yet, we know little about the lives of most wild bumble bee species. Where do they live? When are they active? What do they eat? What does all this mean for the future of...
- Keyword:
- bees, love data week, and data visualization
- Subject:
- Biology
- Creator:
- Ogilvie, Jane, Fitzgerald, Jacquelyn, and CaraDonna, Paul
- Owner:
- Chris Diaz
- Date Uploaded:
- 04/21/2021
- Date Modified:
- 04/21/2021
- Date Created:
- 2021
- Resource Type:
- Poster
-
- Description:
- A central question in biology is how the flow of genetic information—from DNA to RNA to protein—is regulated. Regulatory mechanisms exerted at the level of DNA and protein have been described in detail but by contrast, little is known regarding the regulation of RNA. Methylation on N6-adenosine (m6A) is the...
- Subject:
- Biology
- Creator:
- Edens, Brittany M
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/15/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_796993 and http://dissertations.umi.com/northwestern:15475
-
- Description:
- Prostate cancer (PCa) is the second most common cancer in American men and has led to approximately 29K deaths in 2018. The androgen signaling pathway plays a pivotal role in the pathogenesis of PCa, and androgen deprivation therapy (ADT) has been the main therapeutic approach for PCa. However, almost all...
- Keyword:
- lysine methylation, FOXA1 methylation, WD40 motif protein, FOXA1 ubiquitination, ChIP-seq, and polycomb repressive complex 2
- Subject:
- Biology
- Creator:
- Park, Su Hong
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/15/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15433 and etdadmin_upload_787083
-
- Description:
- The BCR-ABL negative Myeloproliferative Neoplasms (MPNs) are clonal hematopoietic stem-cell disorders characterized by abnormal proliferation of differentiated myeloid lineages. MPNs include 3 clinically distinct disorders: Polycythemia Vera (PV), Essential Thrombocythemia (ET) and Primary Myelofibrosis (PMF). 95% of MPNs are characterized by driver mutations in Janus Kinase 2 (JAK2), Thrombopoietin receptor...
- Keyword:
- STK11, AML, Megakaryocytes, Reactive Oxygen Species, Leukemia, and MPN
- Subject:
- Biology and Medicine
- Creator:
- Marinaccio, Christian
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/15/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15470 and etdadmin_upload_796403
-
- Description:
- Ionizing radiation is known for being dangerous at high doses, beneficial for diagnosis and treatment of diseases, and expensive for hazardous waste disposal and other protection policies governments put in place. Balancing the benefits and risks is key to maximizing public health, reducing public fears, and reducing extraneous costs that...
- Subject:
- Biology
- Creator:
- Zander, Alia
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15292 and etdadmin_upload_765069
-
- Description:
- Down syndrome occurs in approximately 1 in 700 births annually in the United States. It is caused by trisomy of chromosome 21, and is characterized by dysmorphic features and congenital abnormalities. Although children with DS have a decreased risk of developing solid tumors, they have an increased risk of acquiring...
- Keyword:
- DYRK1A, B-ALL, FOXO1, and STAT3
- Subject:
- Oncology and Biology
- Creator:
- Rammohan, Malini Krishna
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15335 and etdadmin_upload_771926
-
- Description:
- Mitochondrial complex I is the primary entry point for electrons into the mitochondrial electron transport chain that is composed of 45 individual protein subunits that are encoded in both the nuclear and mitochondrial genomes. Mitochondrial complex I sits at an important nexus in the essential bioenergetic, biosynthetic, and signaling functions...
- Keyword:
- NDI1, NDUFS2, NDUFS4, Mitochondria, Leigh Syndrome, and Metabolism
- Subject:
- Biology, Aging, and Neurosciences
- Creator:
- McElroy, Gregory Scott
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_746970 and http://dissertations.umi.com/northwestern:15152
-
- Description:
- The interaction of amyloid-β (Aβ) with endogenous metal ions is thought to play a role in the pathogenesis of Alzheimer’s disease (AD). However, limited tools exist to study and modulate Aβ-metal binding. The Meade lab has developed cobalt(III) Schiff base (Co(III)-sb) complexes as protein inhibitors that competitively displace metals from...
- Keyword:
- amyloid-beta, aggregation, cobalt(III) Schiff base, and coordination complex
- Subject:
- Biology, Biochemistry, and Neurosciences
- Creator:
- Roberts, Kaleigh Filisa
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_773649 and http://dissertations.umi.com/northwestern:15349
-
- Description:
- Nearly all animals exhibit behaviors that can be classified as sleep. The distinctly disadvantageous nature of the asleep state, evolutionarily speaking, accentuates its role as a critical physiological process, yet chronic inadequate sleep is prevalent in today’s society. Among the multitude of health problems that have been linked to chronic...
- Keyword:
- Metabolome, Stress, Sleep, Sleep Deprivation, Microbiome, and PTSD
- Subject:
- Biology and Neurosciences
- Creator:
- Bowers, Samuel James
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15162 and etdadmin_upload_749831
-
- Description:
- Cell-based therapies are an exciting frontier in medicine. This field is built on a simple premise—cells can be engineered to recognize and treat various human diseases. The paradigm of cell-based therapy uses biosensors to interrogate a cell’s environment and distinguish disease from health, intracellular signaling pathways and genetic circuitry to...
- Keyword:
- Cell-based therapy, Synthetic receptors, Synthetic biology, Biosensors, Transcription factors, and Immunotherapy
- Subject:
- Bioengineering, Biology, and Medicine
- Creator:
- Donahue, Patrick Sean
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Modified:
- 05/06/2022
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15420 and etdadmin_upload_781062
-
- Description:
- A variety of human diseases and pregnancy related disorders reflect endometrial dysfunction. However, rodent models do not share fundamental biological processes with the human endometrium, such as cyclic menstruation, and no existing human cell cultures recapitulate the cyclic interactions between endometrial stromal and epithelial compartments necessary for decidualization and implantation....
- Keyword:
- human endometrial organoid, pluripotent stem cells, epithelial-stromal signaling, cyclic hormone response, human endometrial stromal cells, and human decidua
- Subject:
- Biology and Developmental biology
- Creator:
- Chu, Virginia
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15366 and etdadmin_upload_776955