Dopamine (DA) neurons are involved in many brain functions, and their dysfunction is associated with several neurodegenerative diseases. In recent years, our lab and others have found that DA neurons are molecularly diverse through single-cell gene expression profiling. An outstanding question in the field is whether this heterogeneity is encoded...
Selecting the best material to deliver optimum performance in real-world applications is one of the most significant challenges in engineering. Hundreds of thousands of computationally-predicted, but experimentally unexplored materials exist today in the public inorganic material databases as candidates for consideration. This thesis discusses three projects in the domain of...
This research questions how institutional logics shape and change through the event sequencing of institutional reforms. Literature reviewed on sequences of social events underspecifies the enchainment of events, i.e., the set of social processes that both links events and also renders the sequence meaningful beyond summing its individual events. My...
Superconducting-circuit based platforms are strong contenders in the race to build a quantum computer.While the transmon has had extraordinary success as the leading superconducting qubit modality, there are reasons to believe that other types of qubits could possess relative benefits in terms of noise immunity, anharmonicity, or extensibility. In this...
Fat represents an important source of energy for ovarian cancer (OC) cells and is supplied either through import from the tumor milieu or via de novo lipogenesis. During fast tumor growth, when nutrients are scarce, lipogenesis becomes the primary source of fatty acids. Stearoyl-CoA desaturase (SCD), a rate-limiting enzyme in...
From the early usage of metallic thin films as mirrors tracing back to 2900 BC, to the modern thin film photonic circuits as a mature optical processing platform, and to the growing class of atomically-thin two-dimensional (2D) materials with diverse and tailorable properties, thin film materials have played an important...
Since the dawn of mankind, humans have used materials and tools to dominate the world. As our understanding of the fields physics, chemistry and engineering is growing, we are able to artificially create advanced materials with engineered responses. Next step would be to create ‘ smart’ or intelligent materials capable...
Public-facing data-driven technologies such as social media platforms and search engines rely on data producers, such as users and crowd workers, to be feasible and financially sustainable. Recently, it became clear that the goals of these data-driven technologies do not always align with those of the public, causing public backlashes...
Deterministic models are used to explain and predict the dynamics of ecosystems featuring cyclic competition schemes. The models are systems of reaction-diffusion partialdifferential equations that account for species mobility via Fickian diffusion and interspecies interactions according to the competition scheme. Length and temporal scales are
chosen to be appropriate for...
From colonial practices designed to civilize indigenous communities, to counter-terrorism initiatives aimed at de-radicalizing dissidents in the wake of the War on Terror, to controversies over blasphemy and religious harm cases in international law, religious passions have been cast as a specter of unreason, treason, and radicalization. These assumptions sustain...