Infection with the novel coronavirus, SARS-CoV-2, results in pneumonia and other respiratory symptoms as well as pathologies at diverse anatomical sites. An outstanding question is whether these diverse pathologies are due to replication of the virus in these anatomical compartments and how and when the virus reaches those sites. To...
Dental enamel is a complex bio-composite with compositional and structural features across a wide range of length scales. Defects in these features can compromise enamel’s ability to protect the tooth, resulting in adverse health outcomes. Acquired defects like tooth decay are familiar to most people and are the subject of...
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by motor neuron (MN) degeneration and resulting in progressive paralysis and death. ALS is genetically heterogeneous, disease pathophysiology is not completely understood, and there are no effective drug therapies. To develop broadly applicable therapeutics, we examine disease mechanisms in the...
Many processes in nature and human-made settings rely on the unique properties of charged metal oxide:aqueous interfaces. Despite their ubiquity, these buried interfaces are challenging to study, since any analytical technique aiming to overcome the relatively small number density of interfacial versus bulk species must be highly sensitive and surface-selective....
Political theorists generally ascribe to the state a decisive role in the formation and protection of property rights, a view especially prevalent in the historiography of financial property in the United States. Given the capacities of government at the American Founding, however, such accounts are implausible. Drawing on writings composed...
On 14 January 2017, President Donald J. Trump described the North Atlantic Treaty Organization (NATO) as obsolete. During the first six months of his administration, President Trump discussed not honoring Article 5 commitments for NATO members who had not met the financial responsibilities outlined in the 2014 Wales Summit. His...
Conventional polymer networks are composed of strong, fixed covalent cross-links. The covalent cross-links render polymer networks with outstanding mechanical properties, heat stability, and chemical resistance; however, they also prevent polymer networks from being decross-linked or/and recycled into similar-value products at the end of their life, leading to environmental and economic...
Simple sensorimotor tasks, such as lifting a cup or balancing a tray, requires not only controlled motor output, but also the ability to accurately perceive sensory information. After a hemiparetic stroke, individuals often experience sensory deficits in addition to motor impairments. However, research on the extent of changes in sensory...
Platelets are circulating anucleate discs derived from megakaryocytes, and play major roles in hemostasis, inflammation, thrombosis, and vascular biology. Multi-phase culture systems for inducing in vitro platelet production from mature megakaryocytes have been explored to allow progenitor expansion, megakaryocyte maturation, and promotion of platelet formation and shedding. In this thesis,...
Abstract The overall purpose of this paper is to reconsider the narrative usage and function of a literary phenomenon like ‘opposition/tension/contradiction.’ Throughout my analysis of Alain-Robbe Grillet’s La jalousie, Chloé Delaume’s J’habite dans la television and Jean Genet’s Le Balcon I was focused on investigating the use of this phenomenon...
Recent developments have enabled L12-strengthened Co-based superalloys, which have thepotential to surpass Ni-based superalloys as the material of choice for the hottest sections of turbine
blades due to cobalt’s 40 ºC higher melting point. The most-studied branch of Co-based
superalloys are based on the L12 phase Co3(Al,W); however, there is...
Brain network organization, the emergence of cognition, and the accumulation of neurodegenerative pathology are interwoven concepts frequently studied under the umbrella of behavioral neurology, neuropsychiatry, neuropsychology, and neuropathology. One approach to studying the organization of cognitive processes is to study those with selective deficits in such networks. To understand how...
Regulatory RNAs are found throughout nature controlling critical cellular processes and enabling cells to sense and respond to their environment. In order to provide genetic regulation, these RNAs can selectively bind to target molecules, proteins, and invading pathogens, all while modulating gene expression on both the transcriptional and translational level....
This dissertation traces the rise and the demise of the Amerasian in the years roughly set by the Amerasian Immigration Act (1950-1982). I argue that an Amerasian is not simply an individual fathered by a US servicemen in Asia, nor is it just a racial descriptor used to term mixed...
With the rapid growth of demand for data center services, the energy and water use of data centers has become a critical concern in the contexts of energy use, climate change, and freshwater conservation. Therefore, understanding, quantifying, and optimizing the use of energy and water resources in data centers has...
This dissertation consists of three essays on spatially differentiated markets. Generally, I explore how firms and consumers behave in such markets using structural modeling, causal inference and machine learning techniques, as well as high-resolution spatial data. In the first chapter, I study the efficiency of firm location configurations in the...
Caught between world wars and Stalin’s consolidation of power, citizens of Soviet Russia of the 1920s and 1930s had little to laugh about. Yet a unique tendency toward disruptive humor surfaces in poetry and prose over these two decades. I explore disruptive humor in select longer poetry of Nikolai Zabolotsky,...
This dissertation is composed by three chapters. Chapter one is about productivity hysterisis in the U.S. after the Great Recession. The United States has been experiencing a slowdown in productivity growth for more than a decade. I exploit geographic variation across U.S. Metropolitan Statistical Areas (MSAs) to investigate the link...
Physiochemical phenomena in aqueous systems, such as corrosion, catalysis, and energy storage, are driven by the molecular-scale interactions of ionic species with charged solid surfaces. In particular, an electrical double layer (EDL) of ions forms within nanometers of a charged surface. The properties of the EDL have been explored from...
Asymmetric relationships between creators and consumers in peer-produced knowledge repositories produce inequitable knowledge representation--or knowledge gaps. These gaps result in unequal access to information, and downstream technologies that leverage peer-produced data perpetuate these inequities. Effective knowledge gap identification represents a necessary first step towards equitable knowledge representation. However, while prior...
Humans are prodigious learners. One of our most powerful learning tools is the ability to detect and transfer relational similarities between items and events, despite their perceptual differences. Previous research has found that the roots of this ability extend into infancy. As early as three months of age, infants can...
Transcription is tightly regulated to ensure genes are appropriately expressed both temporally and spatially. This tight regulation governs various processes within the cell, such as differentiation and cell identity, cellular maintenance, and dynamic responses to external signals. Transcription factors (TFs) coordinate these various gene programs and in particular, are key...
This dissertation consists of three chapters about education policies in developing countries. The first chapter examines two extrapolation approaches to make out-of-sample predictions using cash transfer experiments in Malawi and Morocco. The second chapter evaluates India's workfare program in terms of targeting efficiency and effects on school enrollment, in comparison...
This dissertation presents two projects with the goal of understanding how to quantitatively describe biological data, particularly data that is highly dynamic. The first study presents an improved quantitative tool for the analysis of particulate trajectories. Particulate trajectory data appears in several different biological contexts, and the majority of analyses...
Considerable progress has been made in characterizing the neural circuits that underlie stress, fear, feeding, and pain. However, little is known about how they affect each other. Stress bidirectionally regulates feeding, either increases (e.g., stress-induced binge eating) or decreases (e.g., stress-induced anorexia), depending on the types of stressors, duration of...
Gerotranscendence involves feelings of coherence with one’s sense of self, greater acceptance of one’s own life, and connectedness to others across time and space. Gerotranscendence is thought to increase with age. The present study is the first longitudinal effort to investigate changes in gerotranscendence across late midlife using life story...
This thesis focuses on identifying structure-property-performance relationships in supported nanoparticle catalysts, where an active catalyst material is supported on a high surface area substrate. Identifying these relationships in supported nanoparticle catalysts can be quite challenging, as the complex structure of these catalysts results in numerous potential sources for changes to...
Recent discoveries in vitamin D research indicate that vitamin D is a necessary component to several organs and tissues that extends beyond bone formation Furthermore, recent research indicates that vitamin D deficiency is rampant across the globe. Historically, anthropological research has focused on the adaptive significance of skin color to...
Endothelial cells (ECs) require glycolysis for proliferation and migration during angiogenesis; however, the necessity for the mitochondrial respiratory chain during angiogenesis is not known. In this study, we report that inhibition of respiratory chain complex III impairs proliferation, but not migration of ECs in vitro by decreasing the NAD+/NADH ratio....
Exposure to violence, which includes child abuse, neglect, witnessing domestic or community violence, crime, and sexual assault, is a national concern. Over the course of a year, 68% of children under age 17 are exposed to at least one form of violence (Finkelhor, Turner, Shattuck, & Hamby, 2015). Young children...
Herpes simplex encephalitis (HSE) is a rare and severely debilitating life-threatening disease caused by herpes simplex virus type 1 (HSV-1) infection of the human central nervous system (CNS). The severe and often fatal outcomes of HSE contrast starkly with the more frequent and largely benign consequences of herpes labialis. Whole...
Caves are accessible windows into the shallow subsurface, serving as transitional ecosystems between the photosynthesis-dependent surface and the deeper subsurface. Without a source of solar energy to ultimately power carbon (C) fixation (photolithoautotrophy), cave ecosystems are either reliant on surface-derived nutrients, recovering reducing power from the microbial oxidation of redox-sensitive...
Global dementia diagnoses are steeply increasing. While advances in neuroimaging, neuropathology, and genetics research have improved our understanding of neurodegenerative diseases causing dementia, precise antemortem diagnosis, as well as sensitive and specific biomarkers that can facilitate a differential diagnosis and aid in participant recruitment in clinical trials, remains elusive. The...
This dissertation explores critiques of mass education alongside the rise of the research university as they appear in the early writings of Friedrich Nietzsche and Walter Benjamin. More specifically, it traces the development of a theory of (un)learning that inserts distance into the pedagogical relation to produce a discretized educational...
Techniques for achieving complete quantum control over atoms have been developed and perfected over the past four decades with great success. This work has led to multiple Nobel prizes and has been the catalyst for rapid advances in a broad array of research fields. A natural progression forward is to...
Rhythmic oscillations in the brain are widespread. Extracellular recordings of local field potentials (LFPs) using methods ranging from microelectrodes to scalp electroencephalography (EEG) have demonstrated that oscillatory dynamics play a vital role in operations such as network synchronization, sensory tuning and information packaging. Empirical and computational evidence suggest that these...
Biomass has the potential to be our country’s leading renewable source of energy. Specifically, fast pyrolysis is a promising method for the conversion of biomass to valuable fuels and chemicals. Given that fast pyrolysis has a residence time of about two seconds, computational methods are particularly useful in obtaining product...
Cancer is a complex and heterogeneous disease characterized by aberrant gene regulation. Gene regulation is fundamentally orchestrated by the 3D genome organization which involves chromatin looping, compartmentalization, and the formation of topologically associating domains (TADs). Structural variations (SVs), such as genomic rearrangements, deletions, inversions, and duplications, are commonly observed in...
The creative process of an artistic work is a space, figuratively, in which every facet of our personal lives has an effect and, in turn, can be explored and altered. One of the most fundamental aspects of life, be it human or not, is the way in which one relates...
Superconducting qubits are among the leading competitors in the race towards building the first full-fledged quantum computer. Using this platform, researchers have for the first time demonstrated computational capability that is beyond the reach of the current classical machines. (This achievement is nicknamed "Quantum Supremacy".) Up to date, however, the...
From cyber theft of personal financial information to Advanced Persistent Threat (APT) attacks, nowadays endpoint devices suffer from various intrusions which cause inestimable property and privacy loss. To protect the security on endpoints, endpoint detection and response (EDR) systems have been developed to serve as the powerful solution against those...
The Unquenchable Fire examines how the United States outsourced the work and costs of imperialism through arms exports after the Vietnam War. As wartime contracts disappeared and government officials confronted new limits to interventionism, a devastating recession pushed defense contractors abroad in the late 1960s and 1970s. While arms makers...
We present both semiclassical asymptotics for the wave equation on a stationary Kaluza-Klein spacetime and an index theorem describing the difference of the positive-frequency
spectral projectors for two stationary regions in a globally hyperbolic spacetime. The
first result involves analyzing the restrictions of the wave trace to isotypic subspaces for...
This dissertation contains three essays that study the operational challenges and business innovations in service industries. We investigate how service providers could use wisely designed business models and service systems to induce preferable customer behaviors, and therefore manage demand and optimize revenue. Using a stylized model, we study how customers...
Quantum technologies have the capability of greatly increasing the security of communication systems. Many components are required for a full quantum network including memory, repeaters, routers, and detectors. The efficiencies of quantum communication technologies suffer greatly due to their inherent sensitivity to loss. Low-loss propagation and high detection efficiency can...
This thesis studies the distributed optimization of protocols and linear precoding in multiple-input multiple-output (MIMO) wireless networks. We consider cellular systems including millimeter wave (mmWave) systems, frequency-division duplex (FDD) systems, and wideband time-division duplex (TDD) systems. Firstly, for mmWave systems, we design an efficient beam training protocol with multiple access...
Newcomers, or new members to organizations or professions, bring insights that are critical to the advancement of society. Yet newcomers often have low self-efficacy, or low beliefs in their abilities to achieve a task, which can impact performance and retention. Research suggests that self-efficacy can be developed through in-person social...
This dissertation studies the limitations of incentive design in organizations and how they lead to inefficient outcomes. Chapter 1 studies how a coalition coordinates its members when they freely join and leave. It characterizes the conditions under which such coordination prevents the coalition from forming in the first place. In...
This dissertation contains three essays that study the operational challenges in healthcare-related fields. We strive to integrate analytical modeling and empirical methods to study decision-making under uncertainty for practice- and data-driven problems. We use large-scale datasets (millions) gathered from years of data collection. To gain access to these proprietary data,...
Economic and political processes are heavily intertwined. Political processes put constraints on economic activity while economic development influences the way the political system operates. This interconnection is especially tight in developing countries and transition economies with less secure property rights, less stable political institutions, and more rapid economic changes. In...
Following the discovery of n-type Mg3Sb2−Mg3Bi2 alloys, attempts have been undertaken to optimize their thermoelectric performance because understanding of the properties of this system had been limited due to its novelty. In this thesis, the thermoelectric performance of n-type Mg3Sb2−Mg3Bi2 alloys was systematically investigated and significantly improved. Thorough experimental characterization...
In 2009, the Health Information Technology for Economic and Clinical Health Act (HITECH) promoted national use of electronic health records (EHR) in the US by giving incentives to providers who adopt ‘meaningful use’ of EHRs. As of 2017, nearly 86% of office-based physicians had adopted EHRs. EHRs have rich information...
Cancer progression is a complex process, leading to metastatic spread of primary tumor cells that colonize distant vital organs and mortality if not stopped. Since clinical strategies to stem this progression are still being developed, it is of great importance to detect this end stage metastatic spread as early as...
Single-molecule localization microscopy (SMLM) has significantly stimulated the development of methods to quantitatively visualize and characterize biomolecules in vitro and in situ. SMLM is a class of super-resolution microscopy (SRM) techniques, which exploits the “on-off” switching of individual fluorescent molecules to estimate their location with nanometer precision and offers spatial...
The nature of dark matter (DM) remains one of the largest open questions in modern physics despite the many searches for particle dark matter around the world. The search for dark matter particles with masses above 5 GeV/$c^2$ is led by the dual-phase xenon time-projection chamber (LXe-TPC) detector technology which...
This dissertation argues that British and Ottoman literatures of the eighteenth and nineteenth centuries are linked and mutually informed in their representations of sovereignty. My study of the poetry, fiction, chronicles and travelogues from these periods demonstrates that both literary traditions respond to the rivalry between the British and Ottoman...
The interaction of amyloid-β (Aβ) with endogenous metal ions is thought to play a role in the pathogenesis of Alzheimer’s disease (AD). However, limited tools exist to study and modulate Aβ-metal binding. The Meade lab has developed cobalt(III) Schiff base (Co(III)-sb) complexes as protein inhibitors that competitively displace metals from...
Enzyme substrate promiscuity has significant implications for metabolic engineering. The ability to predict the space of possible enzymatic side reactions is crucial for elucidating underground metabolic networks in microorganisms, as well as harnessing novel biosynthetic capabilities of enzymes to produce desired chemicals. Reaction rule-based cheminformatics platforms have been implemented to...
The evolutionarily conserved COMPASS family of methyltransferases implements histone H3 lysine 4 (H3K4) methylation, an epigenetic mark associated with transcriptional activation. Given the high mutational prevalence of COMPASS subunits across cancers and neurodevelopmental disorders, understanding COMPASS function would lend important insights into disease pathogenesis to facilitate development of effective therapies....
This dissertation explores how dominant U.S. constructions of race, class, and gender are embedded into and inscribed onto artificially intelligent virtual assistants and the labors they perform. I examine virtual assistants like Amazon’s Alexa, Apple’s Siri, and Microsoft’s Cortana, interrogating their complex relationship to humanness, the tasks they are programmed...
My research goal is to develop first principles frameworks to interrogate multiphase, multiscale systems. One of my main focus areas is to consistently deconstruct highly nonequilibrium problems into their fundamental components. By using analytical, computational and experimental tools to grasp the key levers controlling such phenomenon, I aim to build...
End-stage renal disease, or kidney failure, can result from acute kidney injury or sustained kidney damage in the form of chronic kidney disease. As the prevalence of end-stage renal disease continues to rise, the gold-standard treatment—kidney transplantation—is increasingly restricted by the shortage of transplantable donor kidneys. Bioengineered kidney tissues may...
Chimeric antigen receptor (CAR) T-cell therapies marry advances in cellular engineering with personalized medicine to provide patient-specific, targeted cancer treatments. Though current CAR T-cell therapies successfully target blood cell cancers, treating solid tumors has proven to be more challenging. Solid-tumor CAR designs must overcome several challenges, including tumor microenvironment barriers...
Nearly all animals exhibit behaviors that can be classified as sleep. The distinctly disadvantageous nature of the asleep state, evolutionarily speaking, accentuates its role as a critical physiological process, yet chronic inadequate sleep is prevalent in today’s society. Among the multitude of health problems that have been linked to chronic...
Political stability is fundamental for economic development. Understanding the determinants and consequences of political stability is thus an important topic in development economics and political economy. This dissertation studies how political or economic instability influences economic development and, in turn, how economic factors influence political stability. In Chapter 1, I...
The structural aspects of biological systems are tightly paired with their functions. This understanding has been demonstrated over a broad range of length scales, spanning the ultrastructure of a cell to the macroscopic architecture of organs. Connecting structure and function relies on the integration of physical and biological sciences to...
A major distinction among different skeletal muscles in the human body is the number, size, and arrangement of its cells, referred to as a muscle’s architecture. Muscle architecture is indicative of a muscle’s ability to contract and produce force and, like muscle function, is plastic. While neuromuscular plasticity is the...
This dissertation focuses on two topics in international macroeconomics: the identification of the international spillovers of US interest rate shocks, and the study of its main transmission channels. In Chapter 1, I present the Spillover Puzzle of US Monetary Policy - the fact that in response to a US interest...
The experiences and environments of working-class children vary dramatically from their more affluent peers. I update Bronfenbrenner’s (1986) ecological systems theory to account for the technology children interact with and child social class, using Lareau’s (2003) frameworks that establish class differences in parenting practices. I position child technology devices at...
This thesis explores how beyond-the-Standard-Model physics interactions could lead to the detection of neutrino decay with lifetimes that are orders of magnitude smaller than a second. I mainly focused on right-handed neutrino fields, new heavy states, and non-zero daughter neutrino masses, assuming the neutrinos are Dirac fermions. An extensive description...
Organic semiconductors are an active area of research with great promise for delivering next generation electronics and clean energy technologies. As the field matures, understanding the connection between molecular structure, materials’ properties, and device performance will be critical in finding the right material for an intended application. An effective strategy...
ABSTRACTFor several decades, dams have played an essential role in human development. In many low-and middle-income countries (LMICs), the construction of dams remains an integral part of industrialization and modernization. However, dam construction and associated infrastructure have significantly contributed to socioecological destruction and population displacement. For example, the construction of...
Supported transition metal oxides are an important class of catalysts with a wide range of industrially relevant applications. However, commonly used synthesis techniques to prepare these catalysts often result in a complex mixture of surface species. This inhomogeneity makes it difficult to understand what specific structures might be responsible for...
Pablo Escobar is not only part of Colombia’s cruel past but also of its very difficult present. Escobar was one of the first major modern drug traffickers, and the founder and head of the Medellín Cartel. He was responsible for more than four thousand deaths. He had an incalculable fortune...
This dissertation asks how can researchers more equitably design sociotechnical interventions to support the information work of sheltered emerging adults. Through two research studies, I explore the technology use in fulfilling the information needs among this population as well as how their environment impacts their strengths and information practices. I...
This dissertation combines perspectives from social networks and teams research to advance understanding of team self-assembly. Across three substantive chapters, I explore team member search behaviors and invitation patterns in contexts where individuals exercise agency to select team members. First, I consider the search for team members in a social...
Given the enormous diversity that exists in our society today, the need intensifies for educators to create a transformative environment that fosters productive encounters with the differences that emerge in a diverse society. Nonetheless, limited attention has been devoted to generating a systematic understanding of how students engage with and...
Clustering is a fundamental task in unsupervised learning, which aims to partition the data set into several clusters. It is widely used for data mining, image segmentation, and natural language processing. One of the most popular clustering methods is centroid-based clustering, including k-medians and k-means clustering. k-medians and k-means clustering...
Frontotemporal dementia (FTD) encompasses a group of neurodegenerative disorders characterized by cognitive and behavioral impairments. Heterozygous mutations in progranulin (PGRN) cause familial FTD and result in decreased PGRN expression, while homozygous mutations result in complete loss of PGRN expression and lead to the neurodegenerative lysosomal storage disorder neuronal ceroid lipofuscinosis...
One of the pressing concerns of the fifteenth century was monastic reform, and reformers of the Observant movement rose to meet the challenge by attempting to return monastic houses to stricter observance of their earliest rules and governing documents. In this dissertation, I examine how Dominican nuns in German-speaking parts...
In Due Time: Performance and the Psychic Life of Black Debt analyzes how routine modes of debt and indebtedness restrict black women’s behavior across the everyday sphere and their subsequent engagement with both aesthetic and everyday performance to dismantle such routines. Modes of indebtedness are characteristic of racial capitalism and...
Responsiveness -- the time it takes for a message recipient to respond to a message -- has long been of interest to scholars in the fields of computer-mediated communication and human-computer interaction. It has been hypothesized that responsiveness is used to signal emotional information, and many empirical studies have demonstrated...
This dissertation focuses on the study of the superionic state in multicomponent systems, where the smaller component exhibits delocalization and mobility while still maintaining system compactness through component attractions. Superionic behavior is widely observed in various systems and plays a crucial role in ceramic superionic conductors, which offer high ion...
Abstract The work presented in this dissertation addresses three broad areas of video signal processing: video transmission, motion estimation and error concealment. In the first category, focused on the source-side, we present two machine learning models for efficient content-aware resource allocation and packet prioritization for video transmission over shared/constrained, lossy...
Glioblastoma (GBM) is a highly malignant brain tumor that accounts for the most commonly diagnosed type of primary brain tumors in adults. It has a poor prognosis of only 15 months from the time of diagnosis. The gold standard therapy regimen consists of radiotherapy and the chemotherapeutic temozolomide. Both of...
Chapter 1 investigates asks the question how do financial frictions affect the type of human capital investments that students make in college? To study this question, I build a novel dataset covering more than 700,000 U.S. students, merging commencement records with address histories, credit bureau records, and professional resumes. I...
One of the greatest challenges in heterogeneous catalysis is the rational design and development of new catalytic systems, due to synthetic limitations in the design of solid catalysts and inhomogeneity of chemical sites at solid surfaces. This obfuscates understanding of catalyst behavior and slows improvements of processes. One approach to...
This dissertation focuses on two topics: macroeconomic implications of consumer inertia, and sovereign debt. In Chapter 1, I explore the role of consumer inertia---persistence in households' consumption choices---as a driver of the rise in corporate profits and decline in the share of young firms in the US economy during the...
The excitation of seismic waves depends on the geologic processes of an earthquake. The waveforms at seismic stations can be modeled as linear combinations of derivatives of Green's functions, which describe the response at the receiver location due to excitation at the seismic source location considering wave propagation effects given...
This dissertation describes investigations into the two primary mechanisms by which the optical bandgap of colloidal quantum dots (QDs) may be post-synthetically modified: (i) by the quantum-confined Stark effect and (ii) by exciton-delocalizing surface capping ligands. This work demonstrates that through the use of ligand-exchange strategies that enable either of...
Research shows the increasing tendency of political considerations to influence decisions outside the context of politics. This work documents examples of partisan affiliation influencing judgments and behaviors – and often resulting in favoritism or discrimination – in ostensibly nonpolitical contexts such as the workplace, academia, and dating, among others. To...
Microfluidic technologies enable multi-tissue culture and precise control of media exchange and therefore have significant potential to create more complex in vitro models of reproductive systems, including endocrine cycles. However, microfluidic technologies have largely been applied to gamete-level culture in reproductive biology, with very little progress in organ-level culture. Herein...
Pathogenic bacteria scavenge essential nutrients including metals, amino acids and peptides to survive within the hostile host environment. Bacteria utilize ATP-binding cassette (ABC) transporters, powered by the energy of ATP hydrolysis, to move substrates across cellular membranes. The substrate-binding protein (SBP) shuttles substrate in the periplasm and directs the substrate...
Clean water supplies are required for industry and general life. However, water shortages dueto pollution and human activity are increasingly common, and new, more efficient, materials need
to be made to increase clean water supplies. To do this, fundamental information on the interaction
of water with ions at the atomic...
Soil-Machine Interaction (SMI) is ubiquitous on Earth and other planets. Over decades, ground-engaging equipment has been developed and widely used in various engineering applications, including civil construction, agriculture, terrestrial mobility, and even space exploration. However, systematic studies of SMI processes and the corresponding soil behavior are inadequate, which obstructs further...
The ribosome, the cell’s machine for synthesizing proteins, can be thought of as the chef of the cell. Just as a chef reads a recipe and combines ingredients to create a dish, the ribosome reads cellular instructions and connects building block molecules (amino acids) to construct proteins. Like the final...
This thesis describes an exploratory project to develop a highly non-traditional approach to devise novel test methods for characterizing the properties of materials that are essential to the design of sustainable and resilient infrastructure, particularly naturally occurring materials such as soils and rocks. The central idea is that the material...
A functional democratic society rests on the premise that the mass public holds clear preferences for policies, candidates, and more. To arrive at these preferences, many citizens rely on their social identities, making political decisions based on what they see as benefitting the groups to which they belong. They may...
In an era of personalized medicine, the clinical community has become increasingly focused on understanding diseases at the cellular and molecular level. Magnetic resonance imaging (MRI) is a powerful imaging modality for acquiring anatomical and functional information. However, it has limited applications in field of molecular imaging due to low...
For some inducible genes, the rate and molecular mechanism of transcriptional activation depend on the prior experiences of the cell. This phenomenon, called epigenetic transcriptional memory, accelerates reactivation, and requires both changes in chromatin structure and recruitment of poised RNA polymerase II (RNAPII) to the promoter. A well-established model for...