Northwestern University

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Cobalt (III) Schiff-base Complexes as Inhibitors of Pathogenic Metalloproteins

Description:

Cobalt(III) Schiff-base complexes (Co(III)-sb) have been utilized in the literature as antibacterial, antiviral, and inhibitory agents. Recent work has utilized their ability to displace endogenous metals from metalloproteins that exhibit aberrant gain of function pathologies in human disease. Specifically, in this dissertation Co(III)-sb has been applied as inhibitors of pathogenic...

Keyword:

Transcription Factors, Coordination Complexes, Cobalt, Amyloid-beta, Molecular Dynamics, and Intrinsically Disordered Proteins

Subject:

Chemistry, Biochemistry, and Biophysics

Creator:

Brue, Christopher Robert

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/02/2022

Date Created:

2021-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:15862 and etdadmin_upload_863221