"Anosognosia" or lack of insight into one's own illness is not uncommon in central nervous system disease. Neurodegenerative diseases of the brain that cause dementia are often associated with anosognosia. A lot is known about anosognosia in Alzheimer's disease but relatively little is known about lack of insight into illness...
The polymerization of the microtubule-associated protein, tau, into insoluble filaments is common to Alzheimer's disease (AD) and in a variety of dementias. The conformational change required for tau to transition from soluble monomers to filamentous AD pathology involves the extreme N-terminus of tau coming into contact with other regions of...