In this dissertation, we aim to develop a theoretical understanding of foundation models and reinforcement learning. We delve into a comprehensive analysis of specific aspects within these domains. The focal points of our study are as follows: • Generative Adversarial Imitation Learning (GAIL) with Neural Networks: GAIL is poised to...
Rivers and streams play a critical role in connecting major global carbon pools – land, oceans, and atmosphere. The longitudinal flow in rivers and streams allows for the integration and transport of fluvial particulate organic carbon (POC) from various sources and its continual transformation. A continuum-oriented perspective suggests longitudinal variations...
Kaposi’ sarcoma-associated herpesvirus (KSHV) causes primary effusion lymphoma (PEL). PEL cell lines require expression of the cellular FLICE inhibitory protein (cFLIP) for survival, although KSHV encodes a viral homolog of this protein (vFLIP). Cellular and viral FLIP proteins have several functions, including, most importantly, the inhibition of pro-apoptotic caspase 8...
The relationship between the structure and function of proteins is a fundamental problem in biology with implications for the future of biotechnology and global health. For example, changes to the structure of a coronavirus spike protein led to a global pandemic where our best defenses were vaccines that could only...
Scholarly inquiry has yielded a wealth of evidence in support of narrative-based strategies for persuasion, and yet support for this approach is less consistent in relation to contentious or controversial issues. To better understand why this might be the case, the first part of this dissertation reports a theoretically-guided content...
Prisoner reentry has become an increasingly popular topic of research in the past few decades due to the phenomenon of mass return as a result of the era of mass incarceration. While research has been done on the experiences of the returning population before mass incarceration, few contemporary researchers have...
Ankle sprains are the most common musculoskeletal injury. After an ankle sprain, about 40% of individuals develop Chronic Ankle Instability (CAI), resulting in recurrent sprains, the ankle giving way, or feelings of instability. Most sprains occur due to excess inversion of the ankle. Frontal-plane ankle stiffness quantifies the ankle’s ability...
“National Acts: Performance, Commemoration, and the Construction of American Public Memory” explores how sites of public commemoration created during and after the American Civil War crafted conceptions of American public memory and identities through performative processes. This dissertation looks at three commemorative efforts: the Freedmen’s Memorial Monument to Abraham Lincoln,...
Dental enamel is a complex bio-composite with compositional and structural features across a wide range of length scales. Defects in these features can compromise enamel’s ability to protect the tooth, resulting in adverse health outcomes. Acquired defects like tooth decay are familiar to most people and are the subject of...
Many processes in nature and human-made settings rely on the unique properties of charged metal oxide:aqueous interfaces. Despite their ubiquity, these buried interfaces are challenging to study, since any analytical technique aiming to overcome the relatively small number density of interfacial versus bulk species must be highly sensitive and surface-selective....